Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

Abstract: An air-cooling micro drop pill capsule production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus.

Abstract: User generated content, particularly Chinese language content, is retrieved from various sources such as forums, microblogs, social media sites, and the like. A portion of the content is manually labeled with a sentiment associated with the content and may be classified according to subject matter referenced. Sentiment-indicating features of the content is extracted according to a sentiment dictionary, which may include topic-specific jargon. The features are used to train a classifier to determine sentiment of content based on sentiment-indicating features. The sentiment for other content may then be determined using the classifier. The output of the classifier may be combined with an explicit rating of a product or product feature.

Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.

Abstract: The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis.

Abstract: A computer system receives data sets for a driving maneuver at a location, such as data regarding a state of a vehicle, an external environment indicated by external sensors, and user feedback regarding the driving maneuver. Data sets may be collected from users having various demographic and behavioral attributes. Users may be selected using design of experiment (DOE) algorithms to cover a wide range of possible combinations. A stochastic response surface model (SRSM) is generated that relates sensor data (vehicle state and environmental) to user feedback regarding safety and comfort. The SRSM may be generated using Gaussian process regression (GPR) in order to model uncertainty. The SRSM is then used to generate a control model using an optimization under uncertainty (OUU) algorithm.

Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.

Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

Abstract: An approach is provided for building a scalable service platform by initiating transmission of encrypted data from a public network cache. An access control server platform determines a first authorization key for a user and a second authorization key for a resource, and then encrypts the resource with the second authorization key, and encrypts the second authorization key with the first authorization key. The access control server platform initiates distribution of the encrypted second authorization key with the encrypted resource over a network. The access control server platform further initiates caching the encrypted second authorization key with the encrypted resource that meets a predefined threshold value (e.g., a data size, an access frequency, a modification frequency, or an auditing requirement) in a cache in the network, and initiates transmission of the cached and encrypted second authorization key with the cached and encrypted resource from the cache to at least one authorized entity.

Abstract: A method of forming a package and a package are provided. The method includes placing a main die and a dummy die side by side on a carrier substrate. The method also includes forming a molding material along sidewalls of the main die and the dummy die. The method also includes forming a redistribution layer comprising a plurality of vias and conductive lines over the main die and the dummy die, where the plurality of vias and the conductive lines are electrically connected to connectors of the main die. The method also includes removing the carrier substrate.

Abstract: Techniques for accelerated authentication include receiving first data that indicates a first portion of user credentials for a first user but not a second portion. It is verified whether the first portion of user credentials is valid. If the first portion of user credentials is valid, then second data that indicates a valid value for the second portion of user credentials for the first user is sent. Other techniques include receiving first data that indicates a first portion of user credentials for a first user but not a second portion of user credentials for the first user. A first message that indicates the first portion of user credentials is sent to a remote process that initiates authentication of the first user based on the first portion of user credentials before receiving second data that indicates the second portion of user credentials for the first user.

Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

Abstract: The present invention provides a method for inhibiting lymphangiogenesis in a subject, comprising administering a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor to the subject. The invention further provides a method for inhibiting tumor lymphatic metastasis in a cancer patient, comprising administering to the subject (a) a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor, in combination with (b) a therapeutically effective amount of a VEGF-C inhibitor and/or a VEGF-D inhibitor and/or a VEGFR-3 inhibitor.

Abstract: A method, apparatus, system, and computer program product provide the ability to extract level information and reference grid information from point cloud data. Point cloud data is obtained and organized into a three-dimensional structure of voxels. Potential boundary points are filtered from the boundary cells. Level information is extracted from a Z-axis histogram of the voxels positioned along the Z-axis of the three-dimensional voxel structure and further refined. Reference grid information is extracted from an X-axis histogram of the voxels positioned along the X-axis of the three-dimensional voxel structure and a Y-axis histogram of the voxels positioned along the Y-axis of the three-dimensional voxel structure and further refined.

Abstract: The present invention provides use of endostatin or a functional variant thereof in the preparation of a medicament for treating dietary obesity, non-alcoholic fatty liver disease, insulin resistance or glucose intolerance. In the embodiments of the present invention, the functional variant may be YH-16, mES, mYH-16, m003, m007, mZ101, or the like.

Abstract: Methods of testing, manufacturing, and packaging semiconductor devices are disclosed. In some embodiments, a method of testing a semiconductor device includes providing an integrated circuit die having contacts disposed thereon, forming an insulating material over the integrated circuit die and the contacts, and forming an opening in the insulating material over the contacts. A eutectic material is formed in the openings over the contacts, and the integrated circuit die is electrically tested by contacting the eutectic material disposed over the contacts. The eutectic material is removed.

Abstract: Methods of testing, manufacturing, and packaging semiconductor devices are disclosed. In some embodiments, a method of testing a semiconductor device includes providing an integrated circuit die having contacts disposed thereon, forming an insulating material over the integrated circuit die and the contacts, and forming an opening in the insulating material over the contacts. A eutectic material is formed in the openings over the contacts, and the integrated circuit die is electrically tested by contacting the eutectic material disposed over the contacts. The eutectic material is removed.

Abstract: An approach is provided for authorizing one or more services from service providers in a communications network. The approach includes receiving a request from a first service provider, the request having an associated primary token and a secondary token identifier, the secondary token identifier relating to resources of a second service provider. Based, at least in part, on the secondary token identifier, a secondary token is identified; and then the secondary token is sent to the first service provider, wherein the first service provider and the second service provider belong to different trust domains and the first service provider can use the secondary token to access resources of the second service provider.

Abstract: The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90? having the amino acid sequence of SEQ ID NO:1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.

Abstract: A method, apparatus, system, and computer program product provide the ability to extract level information and reference grid information from point cloud data. Point cloud data is obtained and organized into a three-dimensional structure of voxels. Potential boundary points are filtered from the boundary cells. Level information is extracted from a Z-axis histogram of the voxels positioned along the Z-axis of the three-dimensional voxel structure and further refined. Reference grid information is extracted from an X-axis histogram of the voxels positioned along the X-axis of the three-dimensional voxel structure and a Y-axis histogram of the voxels positioned along the Y-axis of the three-dimensional voxel structure and further refined.