Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: Systems, apparatuses and methods (30) may provide for technology that stores data associated with a plurality of intermediate operations in an autonomous vehicle process (32), generates a visualization output based at least partly on the data (34), and changes a magnification level of the visualization output based on user input (38), the visualization output is generated further based on parameter input and the data includes vector chart data.

Abstract: Disclosed is a prefabricated laminated slab made in accordance with a pretensioning fibermesh anti-cracking process and a manufacturing method thereof, and belongs to the technical field of fabricated structure engineering. The prefabricated laminated slab comprises a concrete layer, fiber grids, distribution bars and truss bars. The fiber grids are subjected to prestress tensioning and pouring to form a novel laminated slab with the pretensioning process, an overall pouring process of layered formworks is adopted, the construction problem during prestress tensioning of the fiber grids of the component can be effectively solved, the crack resistance of the laminated slab can be improved by adopting the prestress grids, the rigidity is increased, and the crack width under normal use conditions is reduced.

Abstract: The present application provide a compound represented by formula (I), a chiral enantiomer thereof or a pharmaceutically acceptable salt thereof, and a preparation method therefor, an intermediate for preparing the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and a preparation method therefor, a pharmaceutical composition comprising the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and pharmaceutical use of the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the same. The compounds of the present application exhibit good JAK2 kinase inhibitory activity and high selectivity for JAK2 kinase.

Abstract: The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.

Abstract: The present application relates to the field of pharmaceutical chemistry, and specifically to cyclopropanecarboxamide-containing compounds of formula (I) and application thereof. The cyclopropanecarboxamide-containing compounds have great medical value and market potential for autoimmune diseases and myeloproliferative neoplasm diseases.

Abstract: The present application provides compounds as shown in Formula (I) and uses thereof. The compounds shown in Formula (I) provided by the present application may serve as effective glucagon-like peptide-1 (GLP-1) receptor agonists. They have excellent GLP-1R receptor agonist activity and significant blood glucose-reducing effect, have better pharmacokinetic characteristics, represent more options for the prevention and/or treatment of GLP-1 activity-related diseases, conditions, or disorders, and thereby have better clinical application prospects.

Abstract: Disclosed is a prefabricated laminated slab made in accordance with a pretensioning fibermesh anti-cracking process and a manufacturing method thereof, and belongs to the technical field of fabricated structure engineering. The prefabricated laminated slab comprises a concrete layer, fiber grids, distribution bars and truss bars. The fiber grids are subjected to prestress tensioning and pouring to form a novel laminated slab with the pretensioning process, an overall pouring process of layered formworks is adopted, the construction problem during prestress tensioning of the fiber grids of the component can be effectively solved, the crack resistance of the laminated slab can be improved by adopting the prestress grids, the rigidity is increased, and the crack width under normal use conditions is reduced.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: An example apparatus for detecting objects in video frames includes a receiver to receive a plurality of video frames from a video camera. The apparatus also includes a first still image object detector to receive a first frame of the plurality of video frames and calculate localization information and confidence information for each potential object patch in the first frame. The apparatus further includes a second still image object detector to receive an adjacent frame of the plurality of video frames adjacent to the first frame and calculate localization information and confidence information for each potential object patch in the adjacent frame. The apparatus includes a similarity detector trained to detect paired patches between the first frame and the adjacent frame based on a comparison of the detected potential object patches.

Abstract: Techniques related to training and implementing a bidirectional pairing architecture for object detection are discussed. Such techniques include generating a first enhanced feature map for each frame of a video sequence by processing the frames in a first direction, generating a second enhanced feature map for frame by processing the frames in a second direction opposite the first, and determining object detection information for each frame using the first and second enhanced feature map for the frame.

Abstract: Provided is a pyrimidine derivative, a preparation method and a use thereof, wherein the pyrimidine derivative is selected from a compound represented by Formula (I), or a tautomer, an enantiomer, a diastereomer, a mesomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt or prodrug thereof. The pyrimidine derivative shows an excellent CDK-inhibiting effect and action.

Abstract: The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.

Abstract: Provided herein is a waterborne resin composition comprising: 1) at least one binder resin comprising a hydroxyl-functional polymer, a carboxyl-functional polymer, a polyol, an amino-functional polymer, a carboxamide, or combinations thereof; and 2) at least one thermosetting resin, wherein the thermosetting resin comprises at least one aminoplast resin; wherein the waterborne resin composition is acid catalyzed. The waterborne resin composition may be a two-part system. Also described is a waterborne coating composition comprising the waterborne resin composition disclosed herein. Further, a process for preparing the waterborne coating composition is also disclosed.

Abstract: Techniques related to training and implementing a bidirectional pairing architecture for object detection are discussed. Such techniques include generating a first enhanced feature map for each frame of a video sequence by processing the frames in a first direction, generating a second enhanced feature map for frame by processing the frames in a second direction opposite the first, and determining object detection information for each frame using the first and second enhanced feature map for the frame.

Abstract: System and techniques are provided for three-dimension (3D) semantic segmentation. A device for 3D semantic segmentation includes: an interface, to obtain a point cloud data set for a time-ordered sequence of 3D frames, the 3D frames including a current 3D frame and one or more historical 3D frames previous to the current 3D frame; and processing circuitry, to: invoke a first artificial neural network (ANN) to estimate a 3D scene flow field for each of the one or more historical 3D frames by taking the current 3D frame as a reference frame; and invoke a second ANN to: produce an aggregated feature map, based on the reference frame and the estimated 3D scene flow field for each of the one or more historical 3D frames; and perform the 3D semantic segmentation based on the aggregated feature map.

Abstract: Systems, apparatuses and methods (30) may provide for technology that stores data associated with a plurality of intermediate operations in an autonomous vehicle process (32), generates a visualization output based at least partly on the data (34), and changes a magnification level of the visualization output based on user input (38), the visualization output is generated further based on parameter input and the data includes vector chart data.

Abstract: Techniques related to training and implementing a bidirectional pairing architecture for object detection are discussed. Such techniques include generating a first enhanced feature map for each frame of a video sequence by processing the frames in a first direction, generating a second enhanced feature map for frame by processing the frames in a second direction opposite the first, and determining object detection information for each frame using the first and second enhanced feature map for the frame.

Abstract: A disclosed example includes selecting, by a mobile computing device, a model description for a predictive analytics model in response to a user-level application request including input data from an application of the mobile computing device, the model description created with a predictive analytics model description language, the model description received from a predictive analytics provider; comparing, by the mobile computing device, first data associated with the user-level application request with second data indicative of digital rights permissions associated with the model description; and executing, by the mobile computing device, an executable associated with the model description without providing the processor circuitry access to the executable and without providing the input data to the predictive analytics provider.

Abstract: An integrated opposite hook cable clamp includes a clamping plate, a connecting plate, and at least two J-shaped clamps. Side bars of the J-shaped clamps are locking bars. Locking holes corresponding to the locking bars are provided on the clamping plate, and at least two of the locking holes are diagonally arranged on the clamping plate. The locking bars of the J-shaped clamps vertically pass through the locking holes on the clamping plate and are movably connected with the clamping plate by a locking mechanism. A back surface of the connecting plate is lap-jointed to the inner sides of hooks of each of the J-shaped clamps. A front surface of the connecting plate is opposite to a front surface of the clamping plate (22).