Abstract: Disclosed herein is a compound of formula (I). An application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for inhibiting interleukin-17A (IL-17A) is further provided.

Abstract: The present disclosure relates to the technical field of microorganisms. The present disclosure relates to a probiotic composition and use thereof in the preparation of a product for preventing and/or treating health conditions such as cancer treatment-related diarrhea. The active ingredients of the probiotic composition include Bifidobacterium bifidum, Enterococcus avium, Lactobacillus salivarius, Limosilactobacillus fermentum, and Parabacteroides distasonis. The probiotic composition has good safety, auto-aggregation ability, antioxidant capacity, ability to produce short-chain fatty acids, in vitro cell adhesion ability, ability to inhibit multiple pathogenic bacteria, ability to treat cancer treatment-related diarrhea, etc.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, and an adenosine inhibitor to treat cancer.

Abstract: The present disclosure relates to combination therapies useful for the treatment of cancer. In particular, the disclosure relates to the combined use of a PD-1 inhibitor, a TGFbeta inhibitor, and a PARP inhibitor to treat cancer.

Abstract: Disclosed is a compound capable of inhibiting interleukin 17A (IL-17A), which is represented by formula (I). An application of the compound or a stereoisomer thereof in the preparation of drugs for inhibiting IL-17A is also provided.

Abstract: Disclosed herein is a compound of formula (I). An application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for inhibiting interleukin-17A (IL-17A) is further provided.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, an ATM inhibitor and radiation to treat cancer.

Abstract: This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising a TGF?RII or fragment thereof capable of binding TGF? and an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1) and (ii) at least one additional anti-cancer therapeutic agent.

Abstract: The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 axis binding antagonist, a TGF? inhibitor and a DNA-PK inhibitor, optionally together with one or more additional chemotherapeutic agents or radiotherapy. The therapeutic combination is particularly intended for use in treating a subject having a cancer that tests positive for PD-L1 expression.

Abstract: This disclosure relates generally to dosage regimens for targeted TGF-? inhibition with a bi-functional fusion protein for use in a method of treating a treatment naïve patient diagnosed with stage III non-small cell lung cancer (NSCLC), and/or mitigating a pathological condition associated with chemotherapy and radiotherapy (cCRT).

Abstract: Collecting online group chat messages. An embodiment of the invention may include determining a received message satisfies at least one of a plurality of message collection rules. The embodiment may also include recording the received message to at least one of a plurality of message tables based on each of a plurality of chat participants mentioned in the received message. The embodiment may further include determining a first chat participant within the plurality of chat participants chooses to open a private chat session with a second chat participant within the plurality of chat participants. The embodiment may also include identifying a plurality of recorded messages within the plurality of message tables where the first chat participant typed a screen name or a given name for the second chat participant and where the second chat participant typed a screen name or a given name of the first chat participant.

Abstract: The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

Abstract: Collecting online group chat messages. An embodiment of the invention may include determining a received message satisfies at least one of a plurality of message collection rules. The embodiment may also include recording the received message to at least one of a plurality of message tables based on each of a plurality of chat participants mentioned in the received message. The embodiment may further include determining a first chat participant within the plurality of chat participants chooses to open a private chat session with a second chat participant within the plurality of chat participants. The embodiment may also include identifying a plurality of recorded messages within the plurality of message tables where the first chat participant typed a screen name or a given name for the second chat participant and where the second chat participant typed a screen name or a given name of the first chat participant.

Abstract: This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising a TGF?RII or fragment thereof capable of binding TGF? and an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1) and (ii) at least one additional anti-cancer therapeutic agent.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.