Abstract: This disclosure relates generally to dosage regimens for targeted TGF-? inhibition with a bi-functional fusion protein for use in a method of treating a treatment naïve patient diagnosed with stage III non-small cell lung cancer (NSCLC), and/or mitigating a pathological condition associated with chemotherapy and radiotherapy (cCRT).

Abstract: A quick connector assembly and a quick connector device are disclosed. The quick connector assembly includes a first base, a first fluid interface assembly and a valve assembly. The valve assembly regulates whether a fluid flows through the quick connector assembly or not, and thereby sealing the flow of the fluid at both sides of the quick connector assembly. The quick connector assembly and the quick connector device in an embodiment of the present disclosure can regulate the flow of the fluid effectively and provide better barriers to keep concurrent flows separated and isolated. Especially, the quick connector device can be used in slurry delivery system which has fluid being abrasive fluid or solid contained liquid.

Abstract: A rotary bucket mixing device is disclosed. The rotary bucket mixing device includes a main body, a rotating disk assembly, a power gear assembly and a first idler assembly. The power gear assembly receives a power to drive the rotating disk assembly to rotate and thereby rotating a mixing bucket disposed on a supporting assembly of the rotating disk assembly and mixing the contents in the mixing bucket. The first idler assembly controls a rotational speed. The rotary bucket mixing device of the present disclosure provides a better support to the mixing bucket and therefore the safety during the mixing process is enhanced.

Abstract: A material mixing and supplying system is provided. The material mixing and supplying system includes a feeding module, at least three mixing and supplying barrels, a supply module, and a control unit, wherein the three mixing and supplying barrels are capable of mixing and supplying the mixed material. The supplying time of the mixed material is greater than a sum of the feeding time and the mixing time. A total operation number of the at least three mixing and supplying barrels is determined by a set amount of mixed material to be supplied by the material mixing and supplying system, and a total time to finish supplying the set amount of mixed material is determined by the total operation number.

Abstract: Collecting online group chat messages. An embodiment of the invention may include determining a received message satisfies at least one of a plurality of message collection rules. The embodiment may also include recording the received message to at least one of a plurality of message tables based on each of a plurality of chat participants mentioned in the received message. The embodiment may further include determining a first chat participant within the plurality of chat participants chooses to open a private chat session with a second chat participant within the plurality of chat participants. The embodiment may also include identifying a plurality of recorded messages within the plurality of message tables where the first chat participant typed a screen name or a given name for the second chat participant and where the second chat participant typed a screen name or a given name of the first chat participant.

Abstract: A mixing apparatus includes a first and a second feeding tube, a first and a second atomizing/refining dose control device, and a reaction chamber. The first and second feeding tubes are arranged in a multi-sleeves manner. The first and second atomizing/refining dose control devices are respectively disposed on terminal ends of the first and second feeding tubes. The reaction chamber accommodates the first and second feeding tubes and the first and second atomizing/refining dose control devices and has a liquid dose mixing wall. The first and second feeding tubes respectively receive a first and a second liquid dose. The first and second atomizing/refining dose control devices respectively atomize or refine the first and second liquid doses and spray the atomized or refined first and second liquid doses on a surface of the liquid dose mixing wall, so as to mix the first and second liquid doses.

Abstract: The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

Abstract: Collecting online group chat messages. An embodiment of the invention may include determining a received message satisfies at least one of a plurality of message collection rules. The embodiment may also include recording the received message to at least one of a plurality of message tables based on each of a plurality of chat participants mentioned in the received message. The embodiment may further include determining a first chat participant within the plurality of chat participants chooses to open a private chat session with a second chat participant within the plurality of chat participants. The embodiment may also include identifying a plurality of recorded messages within the plurality of message tables where the first chat participant typed a screen name or a given name for the second chat participant and where the second chat participant typed a screen name or a given name of the first chat participant.

Abstract: This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising a TGF?RII or fragment thereof capable of binding TGF? and an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1) and (ii) at least one additional anti-cancer therapeutic agent.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: Collecting online group chat messages. The method may include receiving a message associated with an online group chat session between chat participants. The method may also include determining the received message satisfies at least one message collection rule. The method may further include recording the received message to at least one message table based on each chat participant mentioned in the received message. The method may also include determining a first chat participant chooses to open a private chat session with at least one second chat participant. The method may further include identifying recorded messages within the message tables associated with the at least one second chat participant. The method may also include displaying the identified recorded messages in a private chat session sub-window.

Abstract: The invention provides a compound comprising a target specific portion and an effector portion wherein the target specific portion comprises or consists of a monoclonal antibody having specificity for oncofoetal fibronectin, or a fragment or variant thereof which retains the antigen binding specificity of the parent monoclonal antibody and the effector portion comprises or consists of interleukin-12, or a functional fragment or variant thereof, characterized in the monoclonal antibody having specificity for oncofoetal fibronectin binds to a region of oncofoetal fibronectin other than the ED-B region. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, e.g. in the treatment of cancer.

Abstract: Methods directed to enhancing the effectiveness of IL-2 in stimulating the immune system is disclosed. According to one method, an antagonist directed against the CD25 subunit of the high-affinity IL-2 receptor complex is administered in conjunction with IL-2. The CD25 antagonist may be an anti-CD25 antibody. According to another method, an anti-IL-2 antibody is administered in conjunction with IL-2. In another method, a mutant IL-2 with diminished ability to bind the CD25 subunit of the high-affinity IL-2 receptor complex is administered. In another method, an CD4 antagonist is administered in conjunction with IL-2 in order to stimulate the immune system.

Abstract: Disclosed are methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12. In order to insure that the proper ratio of fused and non-fused subunits are obtained in the fusion protein, a specific stepwise approach to genetic engineering is used. This consists of first expressing the non-fused p40 IL-12 subunit in a production cell line, followed by or simultaneously expressing in the same cell, a second recombinant fusion protein consisting of the fused polypeptide linked by a peptide bond to the p35 subunit of IL-12. Molecules containing the p35 fusion protein cannot be secreted from the transfected mammalian cell without first complexing in a one to one ratio with the p40 subunit, thus ensuring the production of active heterodimeric fusion proteins.

Abstract: Disclosed are methods and compositions for treating tumors. Disclosed methods and compositions enhance the uptake of immunocytokines into tumors, and are based on a combination of an immunocytokine with an immunocytokine uptake enhancing agent. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.