Abstract: Provided herein are methods and systems for cell-free DNA extraction from liquid biological samples. The methods can be employed for determination of fetal DNA fraction and non- invasive prenatal screening of fetal aneuploidies and analyses of other types of cell-free DNA.

Abstract: A method for treating Wilson's disease with tetradentate copper chelators therapy is provided. Specific copper chelators of the TDMQ tetradentate series are highly efficient for the treatment of Wilson's disease murine model. The concentration of copper in liver of “toxic milk” TX mice decreased and the fecal excretion of copper increased with the treatment with TDMQ20. Both effects are dose-dependent. Pharmacological data obtained on this TX mouse model with TDMQ20 strongly support the selection of this type of ligand as drug-candidate for this genetic disease.

Abstract: Disclosed herein are relaxin immunoglobulin fusion proteins useful for the treatment or prevention of a disease or condition in a subject.

Abstract: An internet of vehicles communication method includes receiving reported data of a vehicle, sending the reported data to a first regional server in a first cluster, where the reported data includes information about a first location of the vehicle, receiving information about a second location of the vehicle from the first regional server, where the second location is predicted by the first regional server and is about where the vehicle is to arrive, obtaining an identifier or an address of a second distribution device based on the second location when the second location is outside a service region of the first cluster, and sending the identifier or the address of the second distribution device to the vehicle.

Abstract: A machine-learned model includes an encoder having a feature block configured to embed input data into a plurality of features in an embedding space. The input data includes multiple components such as covariate, treatment, and output components. The encoder includes one or more encoding layers, each including a temporal attention block and a feature-wise attention block. The temporal attention block is configured to obtain the embedded input data and apply temporal causal attention along a time dimension in parallel for each feature of the plurality of features to generate temporal embeddings. The feature-wise attention block is configured to obtain the temporal embeddings and generate component representations such as a covariate representation, a treatment representation, and an output representation.

Abstract: Improvements in image quality can be obtained by leveraging non-linear neural-network based feature recovery across multiple imaging modalities. Input imaging data is acquired, including first imaging data and second imaging data acquired using different imaging modalities. The first imaging data can have lower image quality and a larger FOV than the second imaging data. The first and second imaging data can be aligned and the aligned regions can be used to train a neural network to minimize the difference between the second imaging data and output data processed from the overlapping portion of the first imaging data. Once trained, the neural network can be used to generate improved image quality output from all of the first imaging data.

Abstract: Computer-implemented methods for discovery and reuse of a high value pipeline segment are provided. Aspects include defining a set of datasets associated with a processing pipeline based on a set of data operations of the processing pipeline. Aspects also include generating a library of pipeline segments based on the processing pipeline and at least one dataset of the set of datasets. In some aspects, generating the library of pipeline segments includes adding a pipeline segment of the processing pipeline to the library based on one or more characteristics of a dataset generated by the pipeline segment, where the dataset is included in the set of datasets.

Abstract: A display substrate, including: a first base substrate, including a display region and a peripheral region surrounding the display region; at least one common voltage line in the display region, each being configured with at least one conductive connection region; a first passivation layer on a side of the common voltage line away from the first base substrate; a common electrode on a side of the first passivation layer away from the first base substrate; a second passivation layer on a side of the common electrode away from the first base substrate; a pixel electrode on a side of the second passivation layer away from the first base substrate; and a first conductive connection electrode in the corresponding conductive connection region and in the same layer as the pixel electrode, where the common electrode is electrically connected to the common voltage line through the first conductive connection electrode.

Abstract: An imaging lens assembly includes three lens elements which are, in order from an object side to an image side along an optical path: a first lens element, a second lens element and a third lens element. Each of the three lens elements has an object-side surface facing toward the object side and an image-side surface facing toward the image side. The object-side surface of the second lens element is concave in a paraxial region thereof. At least one surface of at least one lens element in the imaging lens assembly has at least one inflection point.

Abstract: Provided by the present disclosure is a power distribution box having a data interaction function, comprising a moving mechanism, a control mechanism and a data interaction mechanism. The moving mechanism comprises an electric valve and an electric telescopic rod. The control mechanism comprises a main control single-chip microcomputer and a control panel. The data interaction mechanism comprises a power distribution box tester and an output port. The electric valve is electrically connected to the main control single-chip microcomputer and is arranged at the bottom of the power distribution box. The control panel is arranged on a support rod and is electrically connected to the main control single-chip microcomputer. The power distribution box tester is electrically connected to the main control single-chip microcomputer and is arranged in the power distribution box, and the power distribution box tester is used for testing electrical devices of the power distribution box.

Abstract: A material completeness detection method configured to detect whether materials of a target object in a physical production line are complete, includes: inputting an image of the target object in the physical production line into a material completeness detection algorithm to acquire a first detection result; inputting a virtual model of the target object in a virtual production line into the material completeness detection algorithm to acquire a second detection result, where the virtual production line is a DT of the physical production line; and acquiring a material completeness detection result of the target object based on the first detection result and the second detection result. The embodiments of the present disclosure can realize efficient and accurate material completeness detection.

Abstract: Embodiments of the present disclosure disclose an information display method and apparatus, an electronic device, and a storage medium. The information display method includes: displaying a live page; obtaining popularity information corresponding to the resource; and displaying the popularity information in an area which is associated with the first multimedia information on the live page.

Abstract: A spin state readout device of a quantum sensor. The quantum sensor has spin-manipulable electrons. The spin state readout device includes: a pumping unit configured to emit a first laser to the quantum sensor to polarize the electron spin state of the quantum sensor; a probing unit configured to emit a second laser to the quantum sensor to make the spin-polarized quantum sensor in an excited state; a signal receiving unit configured to receive fluorescence photons emitted from the quantum sensor and convert optical signals into electrical signals; and a timing unit coupled to the probing unit and the signal receiving unit and configured to time an excited state lifetime of the quantum sensor. The spin state readout device of the quantum sensor provided can reduce spin state reading errors caused by laser power drifts, system signal collection efficiency drifts and the like.

Abstract: This application relates to methods, readable storage media and apparatuses for federated learning. In an example, a first aspect program is injected at a gradient sending function of a federated learning device by using a pre-deployed aspect framework. A to-be-trained model is trained based on local training data to obtain a plaintext gradient of the to-be-trained model. The plaintext gradient is sent to a federated learning server by using the gradient sending function. The plaintext gradient is intercepted and encrypted by using the first aspect program to obtain a ciphertext gradient. The ciphertext gradient is sent to the federated learning server by using the first aspect program, so that the federated learning server decrypts received ciphertext gradients sent by federated learning devices, and updates parameters of the to-be-trained model based on the plaintext gradients obtained after the decryption.

Abstract: Provided is an array substrate. The array substrate includes a substrate, comprising a display region and a peripheral region surrounding the display region, the peripheral region at least including a gate-driver-on-array (GOA) region extending in a first direction; a plurality of thin film transistors, the plurality of thin film transistors being disposed at least in the GOA region; and a plurality of first patterns, wherein the plurality of first patterns are disposed at least on one side of the GOA region, the plurality of first patterns are spaced apart from the GOA region in the first direction, and a plurality of first patterns disposed on a same side of the GOA region are arranged in an array.

Abstract: A display substrate is provided to include: a first base substrate including a sealing region and a display port region, wherein at least one first connection region and at least one second connection region are in the display port region, a first overlapping region is formed between the second and first connection regions; first and second connection terminals in the first and second connection regions, respectively; and a planarization layer including at least one first trench and at least one second trench corresponding to the first and second connection regions therein, respectively; orthographic projections of bottoms of first and second trenches on the first base substrate cover corresponding first and second connection regions, respectively; the planarization layer includes: a first pattern corresponding to the first overlapping region; orthographic projections of the first pattern and its corresponding first overlapping region on the first base substrate overlap with each other.

Abstract: A display substrate, including a plurality of gate lines and a plurality of data lines defining a plurality of pixel regions, where the plurality of pixel regions include a plurality of normal pixel regions and a plurality of redundant pixel regions at a periphery of the normal pixel regions; where each normal pixel region is provided with a first pixel electrode and a first transistor, each redundant pixel region is provided with a second pixel electrode and a second transistor, a gate of the first transistor is connected to a corresponding gate line, a source of the first transistor is connected to a corresponding data line, and a drain of the first transistor is connected to the first pixel electrode; and the second pixel electrode and the second transistor are insulated and spaced apart from each other.

Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.

Abstract: An electrolytic eluent generator includes an electrolyte reservoir and at least one eluent generation cartridge. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution; and a first electrode. The at least one eluent generation cartridge includes a platinum mesh electrode; a polymer screen; a plurality of reinforced membranes; a membrane washer; and a spacer including a central post and an annular projection.

Abstract: Provided are bispecific and multi-specific antibodies that target claudin 6 (CLDN6) and 4-1BB. These antibodies, in the absence of CLDN6-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN6-expressing cells, however, these antibodies can trigger CLDN6-dependent 4-1BB signaling, leading to potent immune response to the CLDN6-expressing tumor cells.