Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: An approach to optimize performance for large scale inference models. Data in the form of images is received from sensors such as cameras. The data is processed to generate data tags associated with the context of the image and portion the images. Model tags are generated based on data characteristics or user input. The tags and their associated data are added to a time-based queue for delivery to the appropriate inference models. Based on the embedded delivery time and frequency, the portioned images are delivered to the appropriate inference models.

Abstract: Synching multiple streams in a complex enterprise product by collecting and analyzing stream dependency data. Collection and analysis of data for large scale and complex enterprise results in a multi-dimensional relationship diagram that highlights the interconnected dependencies of the streams. This allows enterprise software users to more easily determine and select which stream (or streams) will help the user to perform a given task.

Abstract: A method includes predicting, using a machine learning model and based on a received set of user interactions on keywords appearing in a presentation, a knowledge background of the user indicating the user's degree of understanding of the presentation. The method also includes generating, based on the predicted knowledge background, a message comprising a description of a keyword in the presentation and coordinates where the description is to be positioned in the presentation and communicating the message to a device of the user.

Abstract: A nucleic acid preservation solution, a preparation method and application for same is disclosed. The nucleic acid preservation solution of the invention includes, by weight percentage, citric acid 13%-35%, Tween 20 0.50%-2.50%, disodium ethylene diamine tetraacetic acid (EDTA) 13%-40%, sodium sulfate 35%-70%, polyethylene glycol octyl phenyl ether 0.50%-2.50%, and the balance being diethylpyrocarbonate (DEPC) water.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for dynamically matching requestor devices to generate efficient transportation groups that satisfy user-selected arrival deadlines. In particular, in one or more embodiments, the disclosed systems generate timeslots corresponding to a transportation request including pick-up times, arrival deadlines, and transportation values. In response to receiving user selections of timeslots, the disclosed systems can partition requestor devices into sets of requestor devices. Additionally, the disclosed systems can utilize the sets of requestor devices to match compatible requestor devices to both maximize system efficiency and satisfy selected arrival deadlines for each requestor device.

Abstract: A system for path control for a mobile unmanned vehicle in an environment is provided. The system includes: a sensor connected to the mobile unmanned vehicle; the mobile unmanned vehicle configured to initiate a first fail-safe routine responsive to detection of an object in a first sensor region adjacent to the sensor; and a processor connected to the mobile unmanned vehicle. The processor is configured to: generate a current path based on a map of the environment; based on the current path, issue velocity commands to cause the mobile unmanned vehicle to execute the current path; responsive to detection of an obstacle in a second sensor region, initiate a second fail-safe routine in the mobile unmanned vehicle to avoid entry of the obstacle into the first sensor region and initiation of the first fail-safe routine.

Abstract: Systems and methods of unmanned vehicles having self-calibrating sensors and actuators are provided. The unmanned vehicle comprises a communication interface and a processor for controlling a propulsion system of the vehicle and receiving sensor data from one or more sensors of the vehicle. The processor is configured to operate in a guided calibration mode by controlling the propulsion system according to commands received from an external guided control system, while processing the sensor data to determine a degree of certainty on a calibration the sensor data and a position of the vehicle. The processor determines that the degree of certainty is above a threshold value associated with safe operation of the propulsion system in an autonomous calibration mode, and subsequently switch operation of the propulsion system to the autonomous calibration mode based on the determination that the degree of certainty is above the threshold value.

Abstract: In an approach for maintaining data synchronization, a processor scans a set of data fields at each stage of a data analysis process. A processor generates a relationship tree model, wherein the set of data fields each correspond to a node in the relationship tree model. A processor prunes the relationship tree model. Responsive to an update to a data field of the set of data fields, a processor promulgates the update using the relationship tree model to generate an updated set of insight data. A processor outputs the updated set of insight data.

Abstract: A network failure detection method and a network failure detection device are provided. The network failure detection method includes capturing a plurality of packets, analyzing contents of the plurality of packets and determining whether a network failure occurs to generate a determination result according to the contents of the plurality of packets, and outputting an alarm signal to implement an alarm function according to the determination result.

Abstract: Systems and methods of unmanned vehicles having self-calibrating sensors and actuators are provided. The unmanned vehicle comprises a communication interface and a processor for controlling a propulsion system of the vehicle and receiving sensor data from one or more sensors of the vehicle. The processor is configured to operate in a guided calibration mode by controlling the propulsion system according to commands received from an external guided control system, while processing the sensor data to determine a degree of certainty on a calibration the sensor data and a position of the vehicle. The processor determines that the degree of certainty is above a threshold value associated with safe operation of the propulsion system in an autonomous calibration mode, and subsequently switch operation of the propulsion system to the autonomous calibration mode based on the determination that the degree of certainty is above the threshold value.

Abstract: A depth camera calibration device and a method thereof are provided. The method comprises: disabling a projection function of a camera and photographing surface planes to obtain a first image; enabling the projection function of the camera and photographing the surface planes to obtain a second image, and a positional relationship between the camera and a calibration plate assembly remaining unchanged when obtaining the first image and the second image; and obtaining parameters of the camera by cropping an image boundary, calculating positions of characteristic points, reading a projection pattern, calculating positions of corresponding points and excluding abnormal points according to the first image and the second image.

Abstract: A network failure detection method and a network failure detection device are provided. The network failure detection method includes capturing a plurality of packets, analyzing contents of the plurality of packets and determining whether a network failure occurs to generate a determination result according to the contents of the plurality of packets, and outputting an alarm signal to implement an alarm function according to the determination result.

Abstract: A system for path control for a mobile unmanned vehicle in an environment is provided. The system includes: a sensor connected to the mobile unmanned vehicle; the mobile unmanned vehicle configured to initiate a first fail-safe routine responsive to detection of an object in a first sensor region adjacent to the sensor; and a processor connected to the mobile unmanned vehicle. The processor is configured to: generate a current path based on a map of the environment; based on the current path, issue velocity commands to cause the mobile unmanned vehicle to execute the current path; responsive to detection of an obstacle in a second sensor region, initiate a second fail-safe routine in the mobile unmanned vehicle to avoid entry of the obstacle into the first sensor region and initiation of the first fail-safe routine.

Abstract: This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting mechanical forces between a ligand and receptor, where the ligand is immobilized on a surface using weaker forces. Ligand-receptor forces lead to dissociation of the ligand that can be detected and amplified. In certain embodiments, the disclosure relates to methods of detecting ligand and receptor interactions comprising linking a ligand to one of two binding partners, wherein the binding partners have attracting forces that are less than the forces between the ligand and a receptor of the ligand such that when the ligand binds the receptor, the binding partners will separate. Separation of the binding partners can be detected.

Abstract: Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.

Abstract: A computer-implemented method includes receiving, at a datastore having a plurality of records of a transaction-monitoring system, a first record representing a first instance of a transaction. The datastore includes a first layer and a second layer. A first record hash code, based on the first record, is compared to a template hash code set that includes one or more template hash codes, where each template hash code corresponds to a respective transaction in a set of one or more known transactions. The first record is inserted into the first layer of the datastore. The first record is inserted into the second layer of the datastore, based at least in part on the first record hash code not being found in the template hash code set.

Abstract: In an approach for maintaining data synchronization, a processor scans a set of data fields at each stage of a data analysis process. A processor generates a relationship tree model, wherein the set of data fields each correspond to a node in the relationship tree model. A processor prunes the relationship tree model. Responsive to an update to a data field of the set of data fields, a processor promulgates the update using the relationship tree model to generate an updated set of insight data. A processor outputs the updated set of insight data.

Abstract: Compounds of general formula (1): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.