Patents by Inventor Yanan Zhang

Yanan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9150582
    Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: October 6, 2015
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott Runyon, Yanan Zhang, Carla Hassler, Brian Gilmour
  • Patent number: 9133128
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: September 15, 2015
    Assignee: Research Triangle Institute
    Inventors: Alan Bradley Fulp, Rangan Maitra, Yanan Zhang, Herbert H. Seltzman
  • Publication number: 20150057268
    Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.
    Type: Application
    Filed: December 6, 2012
    Publication date: February 26, 2015
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott Runyon, Yanan Zhang, Carla Hassler, Brian Gilmour
  • Publication number: 20150031689
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 29, 2015
    Inventors: Rangan Maitra, Alan Bradley Fulp, Yanan Zhang, Herbert H. Seltzman
  • Patent number: 8777852
    Abstract: An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.
    Type: Grant
    Filed: August 22, 2007
    Date of Patent: July 15, 2014
    Assignee: Medtronic Minimed, Inc.
    Inventors: Yanan Zhang, Lu Wang, Rajiv Shah
  • Publication number: 20140107157
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Application
    Filed: June 15, 2012
    Publication date: April 17, 2014
    Applicant: Research Triangle Institute
    Inventors: Alan Bradley Fulp, Rangan Maitra, Yanan Zhang, Herbert H. Seltzman
  • Publication number: 20130126349
    Abstract: Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked ed via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components. In another embodiment, the membrane includes a solvent cast film which includes a mixture of a first polyether-based thermoplastic polyurethane copolymer, a polyether-based polyurethane copolymer, and, optionally, a second polyether-based thermoplastic polyurethane copolymer.
    Type: Application
    Filed: August 5, 2011
    Publication date: May 23, 2013
    Applicant: MicroCHIPS, Inc.
    Inventor: Yanan Zhang
  • Patent number: 8352011
    Abstract: The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: January 8, 2013
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Nannette M. Van Antwerp, Bradley J. Enegren, John J. Mastrototaro, Rajiv Shah, Udo Hoss, Yanan Zhang, Jenn-Hann Larry Wang, Kent L. Clark
  • Patent number: 8187851
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: May 29, 2012
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Bahar Reghabi, Rudy Montalvo, Yanan Zhang
  • Patent number: 8137927
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: March 20, 2012
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Rajiv Shah, Bahar Reghabi, Rudy Montalvo, Yanan Zhang
  • Patent number: 8110677
    Abstract: This invention relates to a method of extracting crude polysaccharide by microwave-assisted from Artemisia sphaerocephala seed de-oiling dregs. In particular, the invention comprising: microwave-assisted extraction, enzymatic hydrolysis, dialysis et. al. It provides a technique whereby the polysaccharide can be extracted effectively, in a relatively short period of time (20-30 min) with respect to conventional extraction methods and allows for an enhanced extraction yield (more than 30%). Furthermore, the invention also allows for the extraction of material with less solvent consumption, good reproducibility, excellent solubility, energy conservation, environmental protection, and showed great potential for efficient sample preparation and large-scale industrial application in the near future. With great resource advantage of Artemisia sphaerocephala in China, the invention has bright perspectives in promoting local economic development.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: February 7, 2012
    Assignee: Northwest Normal University
    Inventors: Ji Zhang, Junlong Wang, Yiqian Wu, Jian Yao, Yunpu Wang, Junyu Liang, Yanan Zhang, Xiaodong Wang, Xiaoqing Xu
  • Publication number: 20110203923
    Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
    Type: Application
    Filed: August 24, 2010
    Publication date: August 25, 2011
    Inventors: Ronald J. Lebel, Rajiv Shah, Yanan Zhang, Edward Chernoff, Rudolph A. Montalvo
  • Publication number: 20110178381
    Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
    Type: Application
    Filed: March 28, 2011
    Publication date: July 21, 2011
    Inventors: Ronald J. Lebel, Rajiv Shah, Yanan Zhang, Edward Chernoff, Rudolph A. Montalvo
  • Patent number: 7979103
    Abstract: Electrochemical biosensors consisting of two or more needle-shaped electrodes for monitoring of molecules such as glucose in the subcutaneous tissue are provided. The two electrodes are parallel to each other, and are fixed perpendicularly to the planar side of a sensor base which provides skin fixation and electric connection. The needle electrodes are made of rigid conducting materials, capable of inserting into the skin without the need of catheters. One electrode is the sensing electrode and the other, the reference electrode. A compound sensing membrane is attached onto the sensing electrode surface to detect analyzed molecules.
    Type: Grant
    Filed: October 29, 2005
    Date of Patent: July 12, 2011
    Assignee: San Meditech (Huzhou) Co., Ltd.
    Inventor: Yanan Zhang
  • Publication number: 20110144466
    Abstract: Electrochemical biosensors consisting of two or more needle-shaped electrodes for monitoring of molecules such as glucose in the subcutaneous tissue are provided. The two electrodes are parallel to each other, and are fixed perpendicularly to the planar side of a sensor base which provides skin fixation and electric connection. The needle electrodes are made of rigid conducting materials, capable of inserting into the skin without the need of catheters. One electrode is the sensing electrode and the other, the reference electrode. A compound sensing membrane is attached onto the sensing electrode surface to detect analyzed molecules.
    Type: Application
    Filed: February 22, 2011
    Publication date: June 16, 2011
    Inventor: Yanan Zhang
  • Patent number: 7912525
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: March 22, 2011
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
  • Publication number: 20090216007
    Abstract: This invention relates to a method of extracting crude polysaccharide by microwave-assisted from Artemisia sphaerocephala seed de-oiling dregs. In particular, the invention comprising: microwave-assisted extraction, enzymatic hydrolysis, dialysis et. al. It provides a technique whereby the polysaccharide can be extracted effectively, in a relatively short period of time (20-30 min) with respect to conventional extraction methods and allows for an enhanced extraction yield (more than 30%). Furthermore, the invention also allows for the extraction of material with less solvent consumption, good reproducibility, excellent solubility, energy conservation, environmental protection, and showed great potential for efficient sample preparation and large-scale industrial application in the near future. With great resource advantage of Artemisia sphaerocephala in China, the invention has bright perspectives in promoting local economic development.
    Type: Application
    Filed: February 24, 2009
    Publication date: August 27, 2009
    Applicant: NORTHWEST NORMAL UNIVERSITY
    Inventors: Ji ZHANG, Junlong WANG, Yiqian WU, Jian YAO, Yunpu WANG, Junyu LIANG, Yanan ZHANG, Xiaodong WANG, Xiaoqing XU
  • Patent number: 7552522
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: June 30, 2009
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
  • Publication number: 20090149728
    Abstract: The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
    Type: Application
    Filed: November 4, 2008
    Publication date: June 11, 2009
    Applicant: MEDTRONIC MINIMED, INC.
    Inventors: Nannette M. Van Antwerp, Bradley J. Enegren, John J. Mastrototaro, Rajiv Shah, Udo Hoss, Yanan Zhang, Jenn-Hann Wang, Kent L. Clark
  • Publication number: 20090081753
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Application
    Filed: July 24, 2008
    Publication date: March 26, 2009
    Inventors: Rajiv Shah, Bahar Reghabi, Rudolph A. Montalvo, Yanan Zhang