Abstract: The present invention discloses a method for building a co-culture model for Caco-2/RAW-264.7 cells induced by lipopolysaccharides and an application of the co-culture model. The method includes: 1) culturing Caco-2 cells and RAW-264.7 cells; 2) inoculating the 5 Caco-2 cells onto an AP side of an upper chamber of a Transwell plate, and incubating; 3) inoculating the RAW-264.7 cells onto a 24-well plate, and incubating; 4) transferring the upper chamber of the Transwell plate into the 24-well plate; 5) dissolving lipopolysaccharides in PBS to prepare a stock solution, filtering, and diluting for later use; and 6) adding an LPS-10% DMEM medium on a BL side, incubating, and forming an intestinal inflammation model.

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Abstract: The present invention provides a CD19-targeting humanized antibody, and a multispecific antibody, chimeric receptor, antibody conjugate, pharmaceutical composition, and kit comprising the CD19-targeting humanized antibody, and a use thereof in the diagnosis/treatment/prevention of diseases associated with CD19 expression.

Abstract: A dispersant for premixed fluidized solidified soil includes the following raw materials in parts by weight: 5 parts to 15 parts of an anti-adhesion water reducer, 0.5 parts to 0.8 parts of a stabilizer, and 85 parts to 95 parts of water. The anti-adhesion water reducer is compounded by an inorganic dispersant and an aminosulfonic acid-based superplasticizer (ASP), and the inorganic dispersant is at least one selected from the group consisting of sodium silicate, sodium hexametaphosphate, and sodium pyrophosphate. In the present disclosure, on the premise of improving fluidity of mucky cohesive soil slurry, a strength of the fluidized solidified soil at each stage is adjusted through a water-reducing effect of the anti-adhesion water reducer. Moreover, rapid dispersion of the mucky cohesive soil slurry is realized, thus providing key technical support for preparation of the premixed fluidized solidified soil from undisturbed soil in non-dry conditions.

Abstract: Provided in the present invention are a BCMA-targeting single-domain antibody and an encoding nucleotide sequence thereof. Also provided in the present invention are a multispecific antibody, a chimeric antigen receptor, and an antibody conjugate containing the BCMA single domain antibody, and a pharmaceutical composition and kit containing said antibodies, chimeric antigen receptor and antibody conjugate, and the use thereof in the diagnosis/treatment/prevention of diseases associated with BCMA expression.

Abstract: A technological equipment for tank track moving supports is provided and includes a zero-point positioning system, a workpiece identifying system and a clamping apparatus in cooperation with the moving support, the clamping apparatus includes a tooling plate, a clamp and a pressing device for pressing the moving support are detachably connected to the tooling plate, the moving support is located between the clamp and the pressing device, and the pressing device abuts against the moving support. The moving support with different shapes and sizes can be clamped, and the clamping is stable and convenient to operate.

Abstract: Provided is an engineered immune cell. The engineered immune cell expresses (i) a chimeric receptor, and (ii) exogenous CCL3, CCL4 and/or CCL5, has improved tumor killing activity, and can be used to treat cancer, infection or autoimmune diseases.

Abstract: Provided is a chimeric antigen receptor, comprising a ligand-binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The co-stimulatory domain comprises an intracellular region of an NK-activated receptor or a ligand thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a use thereof in treatment of diseases, such as cancers, autoimmune diseases, and infections.

Abstract: Carbon nanoparticle-porous skeleton composite material, its composite with lithium metal, and their preparation methods and use A carbon nanoparticle-porous skeleton composite material, its composite with lithium metal, and their preparation methods and use. In the carbon nanoparticle-porous skeleton composite material, the porous skeleton is a carbon-based porous microsphere material with a diameter of 1 to 100 ?m or a porous metal material having internal pores with a micrometer-scale pore size distribution, and the carbon nanoparticles are distributed in pores and on the surface of the carbon-based porous microsphere material or the porous metal material. The carbon nanoparticle-porous skeleton composite material is mixed with a molten lithium metal to form a lithium-carbon nanoparticle-porous skeleton composite material.

Abstract: A downhole displacement impact method and an impact drilling tool are provided, which relates to the field of drilling tools. The downhole displacement impact drilling tool includes a flow passing sleeve, a first main shaft, an impact-bearing seat, and a second main shaft that are all formed by annular structures and are connected in sequence from top to bottom. A vibration sleeve, a vibration starting seat, and an impact head are connected in sequence from top to bottom on the impact-bearing seat. The vibration sleeve is connected and fixed to the impact head through a connecting sleeve. The vibration starting seat synchronously rotates with the impact-bearing seat through a spline connection therebetween. The vibration starting seat generates an up-down periodic displacement along an axial direction of the vibration starting seat during rotating.

Abstract: The utility model discloses a pipe connection mechanism, a refrigeration system having the same, and a refrigeration appliance. The pipe connection mechanism is used for connecting a flexible pipe and a rigid pipe, and includes: a joint pipe and a sleeve sleeving the flexible pipe, wherein the joint pipe has a first pipe part fixedly connected to the rigid pipe, and a second pipe part forward inserted into the flexible pipe and stretching the flexible pipe in an interference manner; and the sleeve backward sleeves the second pipe part and the sleeve and the second pipe part clamp and fix the flexible pipe together. The refrigeration system includes a rigid pipe and a flexible pipe which are fixedly connected in a fit manner through the pipe connection mechanism.

Abstract: The present invention provides a CD7-targeting humanized antibody, and a multispecific antibody, chimeric antigen receptor, antibody conjugate, pharmaceutical composition, and kit comprising the CD7-targeting humanized antibody, and a use thereof in the diagnosis/treatment/prevention of diseases associated with CD7 expression.

Abstract: An integrated circuit comprising an n-type drift region, a gate structure directly on a first portion of the n-type drift region, a drain structure formed in a second portion of the n-type drift region, the gate structure and the drain structure being separated by a drift region length, a resist protective oxide (RPO) formed over a portion of the n-type drift region between the gate structure and the drain structure, a field plate contact providing a direct electrical connection to the resist protective oxide.

Abstract: Provided is an engineered immune cell. The cell expresses a chimeric antigen receptor comprising an antigen-binding region. The antigen-binding region comprises an anti-CD7 antibody, and the expression of endogenous CD7, at least one TCR/CD3 gene, and at least one MHC-II related gene is suppressed or silenced. Further provided is the use of the engineered immune cell in the treatment of diseases associated with CD7 expression.

Abstract: Provided is a positive electrode material for a lithium ion battery, having the following general formula I: Li1+aNixCoyMnzMcM?dO2?bAb general formula I, wherein ?0.05?a?0.3, 0.8?x?1, 0?y?0.2, 0?z?0.2, 0?c?0.01, 0?d?0.01, x+y+z+c+d=1, and 0?b?0.05; M and M? are different from each other and each independently selected from at least one of La, Cr, Mo, Ca, Fe, Ti, Zn, Y. Zr, W, Nb, V, Mg, B, Al, Sr, Ba and Ta, A is selected from at least one of F, Cl, Br, I and S, and the number of crystallite boundaries N in primary particles of the positive electrode material is from 10.5 to 14.5, wherein N is calculated according to Equation I: N=DS/DX Equation I, wherein DS is an average size of the primary particles, as measured from scanning electron microscope (SEM) image of cross section of the positive electrode material, and DX is an average size of crystallites in the primary particles of the positive electrode material, as measured by an XRD test and calculated by the Scherrer equation.

Abstract: A positive electrode material for a lithium ion battery and a preparation method therefor, and a lithium ion battery, relating to the technical field of secondary batteries. The positive electrode material comprises a high-nickel multi-element positive electrode material, the high-nickel multi-element positive electrode material is formed by agglomerating multiple primary grains, and the primary grains are distributed in a divergent shape along the diameter direction of the high-nickel multi-element positive electrode material, the aspect ratio L/R of the primary grains in the positive electrode material is greater than or equal to 3, and the radial distribution ratio of the primary grains in the positive electrode material is greater than or equal to 60%. The lithium ion battery containing the positive electrode material has high capacity and greatly improved particle strength.

Abstract: A fluidized solidified soil based on gold tailings includes the following raw materials in parts by mass: 75 parts to 80 parts of gold tailings, 5.2 parts to 13 parts of a dispersant solution, and 9 parts to 16 parts of a solidifying material. A preparation method includes the following steps: mixing the gold tailings with the dispersant solution, and then stirring to obtain a suspension slurry of the gold tailings; and adding the solidifying material, and stirring to obtain the fluidized solidified soil. In the present disclosure, the gold tailings are used as a main material, combined with a special dispersant solution and a special solidifying material, and a fluidized solidified soil is prepared with fluidity suitable for pumping and a certain strength after hardening. The fluidized solidified soil prevents the pollution caused by gold tailings landfilling, and can be used as a filling material for various construction projects.

Abstract: The present disclosure relates to the technical field of positive electrode materials of lithium ion batteries. Disclosed a positive electrode material having a multi-cavity structure and a preparation method therefor, and a lithium ion battery. The positive electrode material is formed by aggregation of a plurality of primary particles, and some of the primary particles grow in an oriented manner to form supporting structures, the supporting structures overlapping each other inside the positive electrode material to form a plurality of cavities. The particle strength of the positive electrode material is significantly improved, so that the positive electrode material has the advantage of a long service life. In addition, the impedance of the positive electrode material is reduced, thereby improving the power performance of the positive electrode material.

Abstract: A pixel structure, a display substrate and a driving method therefor, and a display device. The pixel structure includes a plurality of pixel units; each pixel unit comprises a first sub-pixel, a second sub-pixel, a third sub-pixel, and a central sub-pixel; the central sub-pixel is located in an area enclosed by the first sub-pixel, the second sub-pixel, and the third sub-pixel; the minimum distance from the central sub-pixel to at least one of the first sub-pixel, the second sub-pixel, and the third sub-pixel in a same pixel unit is less than the distance between two adjacent pixel units.

Abstract: A cam roller type horizontal extrusion cracking system for walnuts, including feeding, cracking and falling devices fixed accordingly on a stand. The feeding device includes a feeding box; an intermittent feeding roller is arranged therein; one side of the roller includes a feeding baffle plate, the other side includes an adjustable feeding scraper blade mechanism; and opposing feeding slots are formed in the roller. The cracking device includes an extrusion box body; movable and fixed tooth-shaped extrusion plates are oppositely mounted therein; one side of the movable plate opposite the fixed includes an extrusion cam; the plates have a plurality of tooth gaps; a walnut passes through the feeding device, falls into a gap between the plates; the cam drives the movable plate to do a periodic reciprocating motion, to synchronously cooperate with the fixed plate to perform extrusion cracking on the walnut.