Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: Methods and apparatus are provided for scheduling parallel jobs in a system of virtual containers. At least one parallel job is assigned to a plurality of containers competing for a total capacity of a larger container, wherein the at least one parallel job comprises a plurality of tasks. The assignment method comprises determining a current utilization and a potential free capacity for each of the plurality of competing containers; and assigning the tasks to one of the plurality of containers based on the potential free capacities and at least one predefined scheduling policy. The predefined scheduling policy may comprise, for example, one or more of load balancing, server consolidation, maximizing the current utilizations, minimizing a response time of the parallel job and satisfying quality of service requirements. The load balancing can be achieved, for example, by assigning a task to a container having a highest potential free capacity.

Abstract: Methods and apparatus are provided for scheduling parallel jobs in a system of virtual containers. At least one parallel job is assigned to a plurality of containers competing for a total capacity of a larger container, wherein the at least one parallel job comprises a plurality of tasks. The assignment method comprises determining a current utilization and a potential free capacity for each of the plurality of competing containers; and assigning the tasks to one of the plurality of containers based on the potential free capacities and at least one predefined scheduling policy. The predefined scheduling policy may comprise, for example, one or more of load balancing, server consolidation, maximizing the current utilizations, minimizing a response time of the parallel job and satisfying quality of service requirements. The load balancing can be achieved, for example, by assigning a task to a container having a highest potential free capacity.

Abstract: Affinity-based preferential call technique, in one aspect, may improve performance of distributed applications in a hybrid system having heterogeneous platforms. A segment of code in a program being executed on a processor may be intercepted or trapped in runtime. A platform is selected in the hybrid system for executing said segment of code, the platform determined to run the segment of code with best efficiency among a plurality of platforms in the hybrid system. The segment of code is dynamically executed on the selected platform determined to run the segment of code with best efficiency.

Abstract: Affinity-based preferential call technique, in one aspect, may improve performance of distributed applications in a hybrid system having heterogeneous platforms. A segment of code in a program being executed on a processor may be intercepted or trapped in runtime. A platform is selected in the hybrid system for executing said segment of code, the platform determined to run the segment of code with best efficiency among a plurality of platforms in the hybrid system. The segment of code is dynamically executed on the selected platform determined to run the segment of code with best efficiency.

Abstract: The present invention relates to substituted imidazopyridinyl compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as ?-lapachone or ?-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted heterocyclic compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted heterocyclic compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

Abstract: Affinity-based preferential call technique, in one aspect, may improve performance of distributed applications in a hybrid system having heterogeneous platforms. A segment of code in a program being executed on a processor may be intercepted or trapped in runtime. A platform is selected in the hybrid system for executing said segment of code, the platform determined to run the segment of code with best efficiency among a plurality of platforms in the hybrid system. The segment of code is dynamically executed on the selected platform determined to run the segment of code with best efficiency.

Abstract: Affinity-based preferential call technique, in one aspect, may improve performance of distributed applications in a hybrid system having heterogeneous platforms. A segment of code in a program being executed on a processor may be intercepted or trapped in runtime. A platform is selected in the hybrid system for executing said segment of code, the platform determined to run the segment of code with best efficiency among a plurality of platforms in the hybrid system. The segment of code is dynamically executed on the selected platform determined to run the segment of code with best efficiency.

Abstract: The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: Methods and apparatus are provided for scheduling parallel jobs in a system of virtual containers. At least one parallel job is assigned to a plurality of containers competing for a total capacity of a larger container, wherein the at least one parallel job comprises a plurality of tasks. The assignment method comprises determining a current utilization and a potential free capacity for each of the plurality of competing containers; and assigning the tasks to one of the plurality of containers based on the potential free capacities and at least one predefined scheduling policy. The predefined scheduling policy may comprise, for example, one or more of load balancing, server consolidation, maximizing the current utilizations, minimizing a response time of the parallel job and satisfying quality of service requirements. The load balancing can be achieved, for example, by assigning a task to a container having a highest potential free capacity.

Abstract: The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: The present invention relates to substituted imidazopyridinyl compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.