Patents by Inventor Yanbin Liu

Yanbin Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
    Publication number: 20100239525
    Abstract: The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: December 30, 2009
    Publication date: September 23, 2010
    Applicant: ArQule, Inc.
    Inventors: Syed M. Ali, Mark A. Ashwell, Sudharshan Eathiraj, Eugene Kelleher, Jean-Marc Lapierre, Yanbin Liu, Nivedita Namdev, Rocio Palma, Manish Tandon, David Vensel, Neil Westlund, Hui Wu, Rui-Yang Yang
  • RAF Inhibitors and Their Uses
    Publication number: 20100183600
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their syntheses. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: December 4, 2009
    Publication date: July 22, 2010
    Applicant: ARQULE, INC.
    Inventors: Jean-Marc Lapierre, Yanbin Liu, Manish Tandon, Mark A. Ashwell
  • Pyrrolidinone, Pyrrolidine-2, 5-Dione, Pyrrolidine and Thiosuccinimide Derivatives, Compositions and Methods for Treatment of Cancer
    Publication number: 20100178291
    Abstract: The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.
    Type: Application
    Filed: June 19, 2008
    Publication date: July 15, 2010
    Applicant: ARQULE, INC.
    Inventors: Jianqiang Wang, Syed M. Ali, Eugene Kelleher, Yanbin Liu, Jason Hill, Mark A. Ashwell
  • Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential
    Publication number: 20090226395
    Abstract: The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified ?-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as ?-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
    Type: Application
    Filed: May 1, 2009
    Publication date: September 10, 2009
    Applicant: ArQule, Inc.
    Inventors: Mark A. Ashwell, Chiang J. Li, Manish Tandon, Yanbin Liu, Jean-Marc LaPierre, Zhiwei Jiang
  • NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20090176801
    Abstract: The invention provides lapachone analogs and derivatives as well as methods of use thereof. These compounds can be used in pharmaceutical compositions for the treatment or prevention of cell proliferation disorders. These compounds can also be used in the treatment or prevention of cancer or precancerous conditions.
    Type: Application
    Filed: October 16, 2008
    Publication date: July 9, 2009
    Applicant: ArQule, Inc.
    Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Syed Ali, Yanbin Liu, Chiang J. Li
  • RAF Inhibitors and Uses Thereof
    Publication number: 20090136499
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: January 20, 2009
    Publication date: May 28, 2009
    Applicant: ARQULE, INC.
    Inventors: Jean-Marc Lapierre, Nivedita D. Namdev, Mark A. Ashwell, Dennis S. France, Hui Wu, Patrick M. Hutchins, Manish Tandon, Yanbin Liu, Jeff S. Link, Syed M. Ali, Chris J. Brassard, Robb B. Nicewonger, Anton Filikov, Rebecca J. Carazza
  • RAF inhibitors and their uses
    Patent number: 7501430
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: March 10, 2009
    Assignee: ArQule, Inc.
    Inventors: Jean-Marc Lapierre, Nivedita D. Namdev, Mark A. Ashwell, Dennis S. France, Hui Wu, Patrick M. Hutchins, Manish Tandon, Yanbin Liu, Jeff S. Link, Syed M. Ali, Chris J. Brassard, Robb B. Nicewonger, Anton Filikov, Rebecca J. Carazza
  • 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase
    Publication number: 20080032967
    Abstract: In general, the present invention relates to compounds capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity.
    Type: Application
    Filed: July 8, 2005
    Publication date: February 7, 2008
    Inventors: Mark Ashwell, Yanbin Liu, Syed Ali, Jason Hill, Woj Wrona
  • RAF inhibitors and their uses
    Publication number: 20070281955
    Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.
    Type: Application
    Filed: April 16, 2007
    Publication date: December 6, 2007
    Inventors: Jean-Marc Lapierre, Nivedita Namdev, Mark Ashwell, Dennis France, Hui Wu, Patrick Hutchins, Manish Tandon, Yanbin Liu, Jeff Link, Syed Ali, Chris Brassard, Robb Nicewonger, Anton Filikov, Rebecca Carazza
  • Inhibitors of P38 and Methods of Using the Same
    Publication number: 20070270418
    Abstract: In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.
    Type: Application
    Filed: May 14, 2004
    Publication date: November 22, 2007
    Inventors: Mark Ashwell, Syed Ali, Jifeng Liu, Yanbin liu, Peter Lohse, Belew Mekonnen, Robert Selliah, Manish Tandon, Woj Wrona, Valery Antonenko
  • Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential
    Publication number: 20060034796
    Abstract: The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified ?-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as ?-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Inventors: Mark Ashwell, Chiang Li, Manish Tandon, Yanbin Liu, Jean-Marc LaPierre, Zhiwei Jiang
  • Quinone prodrug compositions and methods of use
    Publication number: 20060035963
    Abstract: The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as ?-lapachone or ?-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Inventors: Mark Ashwell, Manish Tandon, Jean-Marc Lapierre, Yanbin Liu
  • Window-type of integrated air-conditioner
    Patent number: 6314748
    Abstract: A window-type of integrated air-conditioner is mainly characterized in that the assembly of evaporator is composed of several sections of the evaporator connected from the beginning to the end and is arranged in a folded form, its condensers are two sets, to see from the top, they are arranged in a V shape, the intersecting point of the two sets of the condensers is towards the inside of the room, using the present invention has the advantages of higher heat-exchanging efficiency, low noise, well-distribution of heat exchange and marked increase of energy-to-efficiency ratio, etc., such as a window-type of air-conditioner with the refrigerating capacity 2500 W, after this structure is used, its noise can be reduced to 45 dB(A), the energy-to-efficiency ratio can reach 2.5 W/W so as to effectively overcome the deficiencies of the prior art, it is a more ideal new window-type of air-conditioner.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: November 13, 2001
    Assignee: Gree Electric Appliances Inc. of Zhuhai
    Inventors: Jianghong Zhu, Jianmin Chen, Yanbin Liu
  • Window room air conditioner
    Patent number: D474533
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 13, 2003
    Assignee: Gree Electric Appliances, Inc. of Zhuhai
    Inventors: Jianghong Zhu, Jianmin Chen, Hui Zhang, Yanbin Liu, Hui Huang, Wuzhan Ye, Haiyuan Jin