Abstract: The present disclosure provides a display panel and a display device. The display panel includes a display region, a frame region surrounding the display region, a color filter substrate, and an array substrate opposite to the color filter substrate. A black matrix is disposed on a side of the color filter substrate facing the array substrate. The array substrate is provided with a grounding portion located in the frame region. The grounding portion is electrically connected to a portion of the black matrix located in the frame region through a conductive portion. The portion of the black matrix located in the frame region is provided with a first through groove surrounding the display region. The first through groove penetrates the black matrix along a thickness direction of the black matrix. A portion of the first through groove is located between the conductive portion and the display region.

Abstract: This disclosure provides a floor grinding machine. The floor grinding machine includes: a body bracket; a grinding disc connected to the body bracket, wherein the grinding disc has a first position configured to grind a ground and a second position configured to replace a grinding member provided thereon; a first moving wheel provided on the body bracket; a second moving wheel connected to the body bracket, wherein the second moving wheel has a travelling position in which the second moving wheel is capable moving along the ground and an avoiding position in which the second moving wheel is away from the ground. The floor grinding machine has a first working state configured to grind the ground and a second working state configured to travel or to replace the grinding member.

Abstract: An optical device includes an LED chip, a light absorber and/or visible-light luminescent material, and a near-infrared luminescent material, wherein a luminous power of light emitted by the near-infrared luminescent material and the light absorber and/or visible-light luminescent material in a band of 650-1000 nm under the excitation of the LED chip is A, and a sum of a luminous power of light emitted by the near-infrared and visible-light luminescent materials in a band of 350-650 nm under the excitation of the LED chip and a luminous power of residual light emitted by the LED chip in the band of 350-650 nm after the LED chip excites the near-infrared and visible-light luminescent materials is B, with B/A*100% being 0.1%-10%. According to the implementation where the optical device employs the LED chip to combine the near-infrared luminescent material and the light absorber and/or visible-light luminescent material simultaneously.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: The near-infrared luminescent material is capable of efficiently emitting near-infrared light with a peak wavelength of 900 nm to 1,100 nm under an effective excitation wavelength of 250 nm to 750 nm. The luminescent material has the characteristics of wide excitation emission wavelength, high luminous efficiency, uniform luminescence, no impurity phase, high stability, simple preparation and the like. The present invention further provides the light-emitting device prepared from the near-infrared luminescent material. The luminescent material and the light-emitting device provided by the present invention solve the problems of poor stability, low luminous efficiency, high preparation cost and the like of a conventional near-infrared luminescent material and light-emitting device, and have a favorable application prospect.

Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: The present disclosure is related to a display panel. The display panel may include a first light shielding layer (101) in a display region and a second light shielding layer (212) opposite the first light shielding layer (101) in the display region. The first light shielding layer (101) may include a plurality of first openings (112), and the second light shielding layer (212) may include a plurality of second openings (222). The display region may include a middle display region (20A) and a periphery display region (20B). An area of each of the plurality of the first openings (112) in the periphery display region (20B) may be smaller than an area of each of the plurality of the first openings (112) in the middle display region (20A).

Abstract: The present invention provides a BCMA-targeted chimeric antigen receptor (CAR) as well as a preparation method therefor and an application thereof. Specifically, the present invention provides the BCMA-targeted CAR, which comprises a BCMA-targeted scFv, a hinge region, a transmembrane region, and an intracellular signal structure domain. The present invention provides a nucleic acid molecule for coding the CAR and a corresponding expression vector as well as CAR-T cells and application thereof. The CAR of the present invention targets BCMA-positive cells, and can be used for treating BCMA-positive B-cell lymphoma, multiple myeloma and plasma cell leukemia.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A color filter substrate, a display panel and a display device are provided. The color filter substrate includes a common electrode layer and an upper transparent substrate disposed over the common electrode layer. The common electrode layer is provided with a plurality of slits, and orthographic projections of the slits on the upper glass substrate are within an opaque region of the color filter substrate. Orthographic projections of slits in two adjacent rows on the upper transparent substrate are separated by at least two rows of sub-pixel units; or orthographic projections of slits in two adjacent columns on the upper transparent substrate are separated by at least two columns of sub-pixel units.

Abstract: A negative thermal expansion material and a preparation method thereof, and a negative thermal expansion film and a preparation method thereof are provided. The negative thermal expansion material includes Eu0.85Cu0.15MnO3-?, wherein 0???2.

Abstract: The embodiments of the present disclosure provide an array substrate and a method for manufacturing the same, and a display device. The array substrate includes a substrate, wherein the substrate has a display region and a peripheral region surrounding the display region, the display region has a plurality of pixels arranged in an array, and each of the plurality of pixels includes a light transmission region and a light shielding region, and a light shielding block covering at least a part of the light transmission region of at least one pixel close to the peripheral region of the plurality of pixels.

Abstract: The present disclosure is related to a display panel. The display panel may include a first light shielding layer (101) in a display region and a second light shielding layer (212) opposite the first light shielding layer (101) in the display region. The first light shielding layer (101) may include a plurality of first openings (112), and the second light shielding layer (212) may include a plurality of second openings (222). The display region may include a middle display region (20A) and a periphery display region (20B). An area of each of the plurality of the first openings (112) in the periphery display region (20B) may be smaller than an area of each of the plurality of the first openings (112) in the middle display region (20A).

Abstract: The present invention provides a BCMA-targeted chimeric antigen receptor (CAR) as well as a preparation method therefor and an application thereof. Specifically, the present invention provides the BCMA-targeted CAR, which comprises a BCMA-targeted scFv, a hinge region, a transmembrane region, and an intracellular signal structure domain. The present invention provides a nucleic acid molecule for coding the CAR and a corresponding expression vector as well as CAR-T cells and application thereof. The CAR of the present invention targets BCMA-positive cells, and can be used for treating BCMA-positive B-cell lymphoma, multiple myeloma and plasma cell leukemia.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A power supply system includes at least one inverter, at least one cell string, and a transformer, where an input end of the at least one inverter is connected to an output end of the at least one cell string, an output end of the at least one inverter is connected to an input end of the transformer, and an output end of the transformer is configured to output a power supply voltage. The output end of the at least one inverter is connected to an output end of an inverter unit.