Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD40, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD47, and methods of use thereof.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD28, and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric TIGIT (e.g., humanized TIGIT), and methods of use thereof.

Abstract: An approach is provided for traffic sign learning. The approach involves, for example, receiving a plurality of traffic sign observations generated using sensor data collected from a plurality of vehicles. Each of the plurality of traffic sign observations includes location data and sign property data for an observed traffic sign corresponding to said each of the plurality of traffic sign observations. The approach also involves clustering the plurality of traffic speed sign observations into at least one cluster based on the location data and the sign property data. The approach further involves determining a learned sign for the at least one cluster, and determining a learned sign value indicated by the learned sign based on the location data, the sign property data, or a combination of the plurality of traffic sign observations aggregated in the at least one cluster.

Abstract: The present disclosure relates to the genetically modified non-human animals that have a disruption at the endogenous CD132 gene (e.g., CD132 knockout), and methods of use thereof.

Abstract: An approach is provided for determining a negative observation of a road feature (e.g., traffic sign). The approach involves, for example, querying a spatial data structure for a set of location points based on a spatial radius around a location of the road feature. The spatial data structure stores a plurality of location points from a plurality of location traces that did not have a road feature observation. The approach also involves map matching each location trace in the set of location points to a matched path of road links. The approach further involves determining that said each location trace is a negative observation of the road feature based on determining that the location of the road feature falls between two map-matched location points of said each location trace that are on the matched path of road links.

Abstract: The present disclosure relates generally to image signal processing, including encoding signals for image data or artwork. A color blend/print model is used to predict signal detectability and visibility as is printed on a particular substrate, which facilitates object grading prior to print runs.

Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof.

Abstract: The present invention relates to the field of drilling fluids, and discloses a strong plugging drilling fluid suitable for shale gas wells and a preparation method of the drilling fluid. The drilling fluid contains water, bentonite, a tackifier, a flow pattern regulator, a filtrate reducer, a plugging agent, and a weighting agent, wherein, based on 100 parts by weight of water, the content of the bentonite is 1-10 parts by weight, the content of the tackifier is 5-15 parts by weight, the content of the flow pattern regulator is 4-13 parts by weight, the content of the filtrate reducer is 4-13 parts by weight, the content of the plugging agent is 20-55 parts by weight, and the content of the weighting agent is 10-60 parts by weight; the drilling fluid provided in the present invention employs modified nano-silica as a plugging agent to improve dispersity and particle size distribution in the drilling fluid system.

Abstract: The present disclosure relates generally to image signal processing, including encoding signals for image data or artwork. A color blend/print model is used to predict signal detectability and visibility as is printed on a particular substrate, which facilitates object grading prior to print runs.

Abstract: The present disclosure provides an MEMS microphone, including a substrate having a back cavity and a capacitor system fixedly disposed on the substrate, where the capacitor system includes a backplane and a vibrating diaphragm that are spaced apart from each other, the backplane includes a backplane insulation layer and a backplane conducting layer disposed on the backplane insulation layer, an outer edge of the backplane conducting layer is provided with a notch, the backplane insulation layer is provided with a first through hole, the first through hole includes a first sound hole disposed in a location corresponding to the notch, and the notch is in communication with the first sound hole. The present disclosure reduces stress concentration of the backplane and reducing a risk of structural failure such as breaking of the backplane.

Abstract: The present invention relates to the field of drilling fluids, and discloses a strong plugging drilling fluid suitable for shale gas wells and a preparation method of the drilling fluid. The drilling fluid contains water, bentonite, a tackifier, a flow pattern regulator, a filtrate reducer, a plugging agent, and a weighting agent, wherein, based on 100 parts by weight of water, the content of the bentonite is 1-10 parts by weight, the content of the tackifier is 5-15 parts by weight, the content of the flow pattern regulator is 4-13 parts by weight, the content of the filtrate reducer is 4-13 parts by weight, the content of the plugging agent is 20-55 parts by weight, and the content of the weighting agent is 10-60 parts by weight; the drilling fluid provided in the present invention employs modified nano-silica as a plugging agent to improve dispersity and particle size distribution in the drilling fluid system.

Abstract: Methods employ sensors in portable devices (e.g., smartphones) both to sense content information (e.g., audio and imagery) and context information. Device processing is desirably dependent on both. For example, some embodiments activate certain processor intensive operations (e.g., content recognition) based on classification of sensed content and context. The context can control the location where information produced from such operations is stored, or control an alert signal indicating, e.g., that sensed speech is being transcribed. Some arrangements post sensor data collected by one device to a cloud repository, for access and processing by other devices. Multiple devices can collaborate in collecting and processing data, to exploit advantages each may have (e.g., in location, processing ability, social network resources, etc.). A great many other features and arrangements are also detailed.

Abstract: Methods and devices for placing an Access Point (AP) are provided. In one aspect, a method includes obtaining a sampling point matrix by performing sampling in a locating area based on a preset sampling spacing, wherein the locating area comprises: a valid area to be covered by a WLAN and an invalid area outside the valid area, calculating a maximum valid signal strength, sequentially selecting a sampling point without placing AP is placed from the sampling point matrix to be a first sampling point at which an AP is to be placed, calculating a newly-added valid signal strength and a newly-added invalid signal strength in a case that the AP to be placed is placed at the first sampling point, and placing the AP to be placed at the first sampling point when preset conditions are satisfied.

Abstract: The present invention discloses a micro-nano composite plugging agent for drilling fluid, a preparation method of the micro-nano composite plugging agent for drilling fluid, a drilling fluid, and an application thereof. The composite plugging agent contains nanometer calcium carbonate, nanometer zinc oxide whiskers, nanometer emulsified paraffin, a flocculating agent, and a lubricant, wherein in the composite plugging agent, the nanometer calcium carbonate is in 10-36 parts by weight, the nanometer zinc oxide whiskers are in 20-40 parts by weight, the nanometer emulsified paraffin is in 30-70 parts by weight, the flocculating agent is in 1-10 parts by weight, and the lubricant is 5-20 parts by weight.

Abstract: A variety of technologies having practical application in retail stores are detailed. One is an improved method of identifying items selected by customers. This method includes receiving sensor data from plural sensors, including (a) ceiling-mounted cameras that monitor tracks of customers through aisles of the store, and (b) inventory sensors that are positioned to monitor removal of stock from store shelves. This received sensor data is employed in evaluating plural alternate item identification hypotheses. These hypotheses include a first hypothesis that a customer selected an item having a first identity, and a second hypothesis that the customer selected an item having a second identity. A confidence score is associated with each of the first and second item selection hypotheses. These confidence scores are refined as sensor data is received, e.g., increasing a confidence score of one hypothesis, and reducing a confidence score of another.

Abstract: A super-amphiphobic composite material and use of the same as an inhibitor, lubricant, reservoir protectant, and accelerator in water-based drilling fluids. A method for preparing the amphiphobic composite material includes: performing a first mixing of nano-titanium dioxide and nano-silicon dioxide in an alcohol-water mixed solvent under an alkaline condition, to obtain a dispersion of nano-titanium dioxide and nano-silicon dioxide; then introducing a fluorosilicone-containing coupler into the dispersion of nano-titanium dioxide and nano-silicon dioxide and performing a second mixing. The amphiphobic composite material may be applied in water-based drilling fluids. It has an effect of strongly inhibiting hydrated swelling and disintegration, low toxicity and high compatibility; can solve problems such as well wall instability, blockage of drilling tools, and reservoir damage, etc.

Abstract: A method and device for presenting a prediction model, and a method and device for adjusting a prediction model. The method for presenting a prediction model includes: obtaining at least one prediction result of a prediction model for at least one prediction sample; obtaining at least one decision-making tree training sample for training a decision-making tree model according to the at least one prediction sample and the at least one prediction result, the decision-making tree model being used for fitting the prediction model; training the decision-making tree model by using at least one decision-making tree training sample; and visually presenting the trained decision-making tree model. By means of the method, a prediction model hard to understand can be approximated to a decision-making tree model, and the approximated decision-making tree model is presented, so that a user better understands the prediction model according to the presented decision-making tree model.