Abstract: The invention relates to the field of drilling fluid, and discloses a strong plugging drilling fluid composition and preparation method thereof, and use thereof. The strong plugging drilling fluid composition comprises water, bentonite, Na2CO3, a shale inhibitor, a filtrate reducer, a viscosity reducer, an anti-collapse agent, a nanometer plugging agent, a lubricant and a weighting agent. The shale inhibitor is modified asphalt, the anti-collapse agent is ultra-fine calcium carbonate, and the nanometer plugging agent is polyethylene glycol surface-modified nano-graphene.

Abstract: A method for preparing a NdFeB permanent magnetic material may include providing a covered NdFeB magnetic powder by depositing heavy rare earth particles or high-melting particles onto a NdFeB magnetic powder by physical vapor deposition; and performing orientation molding and sintering on the covered NdFeB magnetic powder to provide the NdFeB permanent magnetic material.

Abstract: Provided is a port switch service (Port Switch Service, PSS), including a server cluster and a client cluster, wherein a master node in the current cluster is elected from the server cluster through a quorum algorithm and is guaranteed to be unique within a specified period in a lease form; the client cluster contains various client nodes needing to use the PSS, and each client node can establish connection with the master node as needed; and each of the client node is identified in the server cluster through the unique node ID. The port switch service is a message routing service integrating distributed coordination functions such as fault detection, service electing, service discovery, and distributed lock. By sacrificing reliability under the extreme condition, the port switch service realizes very high performance, capacity and concurrency capability in the premise of ensuring strong consistency, high availability and scalability.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: Methods employ sensors in portable devices (e.g., smartphones) both to sense content information (e.g., audio and imagery) and context information. Device processing is desirably dependent on both. For example, some embodiments activate certain processor intensive operations (e.g., content recognition) based on classification of sensed content and context. The context can control the location where information produced from such operations is stored, or control an alert signal indicating, e.g., that sensed speech is being transcribed. Some arrangements post sensor data collected by one device to a cloud repository, for access and processing by other devices. Multiple devices can collaborate in collecting and processing data, to exploit advantages each may have (e.g., in location, processing ability, social network resources, etc.). A great many other features and arrangements are also detailed.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric CTLA-4, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric CTLA-4, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) SIRP?, and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric (e.g., humanized) Lymphocyte Activation Gene 3 (LAG-3), and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) glucocorticoid-induced TNFR-related protein (GITR), and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric (e.g., humanized) T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), and methods of use thereof.

Abstract: An expandable plugging agent is described. The expandable plugging agent is obtained through a polymerization reaction of acrylamide, a strength improving material, an acrylate, and gelatinized colloid, the acrylate is obtained through a neutralization reaction of an acidity neutralizer and acrylic acid, and the gelatinized colloid is obtained through a gelatinization reaction of starch in deionized water.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric TIGIT (e.g., humanized TIGIT), and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.

Abstract: The present disclosure relates generally to encoding signals for spot colors. In one implementation a substitute spot color+CMY tint is selected to replace an original spot color. The CMY tint can be transformed to carry an encoded signal. Of course, other features, combinations and technology are described herein.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD27, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.