Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.

Abstract: A surgical instrument comprises an actuator, an extension tube and a controller, wherein the near end of the extension tube is connected with the controller, the far end of the extension tube is connected with the actuator, and the actuator can rotate relative to the far end of the extension tube. The controller comprises a bend control mechanism capable of moving in at least one direction. The extension tube comprises a first flexible component and moves in at least one direction through the bend control mechanism. The first flexible component enables the actuator to rotate relative to the far end of the extension tube towards at least one side. A bendable magazine is further provided. The actuator can bend relative to the far end of the extension tube by a larger angle through the flexible components, thereby being suitable for medical treatment under more complex clinical conditions.

Abstract: The invention relates to a process for producing a microbial storage compound, in particular polyhydroxyalkanoate, using micro-organisms capable of accumulating such microbial storage compound, wherein such micro-organisms are selected and the microbial storage compound is accumulated by carrying out the so-called feast phase of the selection step and the accumulation of the microbial storage compound in selected micro-organisms in the same reactor and carrying out the so-called famine phase of the selection step in a separate, smaller, reactor.

Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.

Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.

Abstract: The invention relates to a process for producing a microbial storage compound, in particular polyhydroxyalkanoate, using micro-organisms capable of accumulating such microbial storage compound,wherein such micro-organisms are selected and the microbial storage compound is accumulated by carrying out the so-called feast phase of the selection step and the accumulation of the microbial storage compound in selected micro-organisms in the same reactor and carrying out the so-called famine phase of the selection step in a separate, smaller, reactor.

Abstract: The present disclosure provides a method, a device, and a terminal apparatus for recognizing a multi-finger sliding gesture. The method includes detecting a plurality of touch events on a touch screen by a user, and acquiring touch event data corresponding to each of the touch events, the touch event data including coordinates of a plurality of touch points and the time of the touch event; calculating an average sliding rate of each of the touch points based on the touch event data; determining that the user's gesture is a multi-finger sliding gesture, if the average sliding rate of each of the touch points is greater than or equal to a preset sliding rate. The method, device, and terminal apparatus for recognizing a multi-finger sliding gesture of embodiment of the present disclosure may implement recognizing of multi-finger sliding gestures so as to meet the needs of the users.

Abstract: The present disclosure provides a method, device, and terminal apparatus for recognizing a multi-finger pinching-in or pinching-out gesture. The method includes detecting a plurality of touch events on a touch screen by a user, and acquiring touch event data corresponding to each touch event, the touch event data including coordinates of a plurality of touch points and the time period of the touch event; calculating an average sliding rate of each touch point and a value of reduced or increased distance between any two of the touch points based on the touch event data; and determining that the user's gesture is a multi-finger pinching-in or pinching-out gesture, if average sliding rate of each touch point is greater than or equal to a preset sliding rate and the value of reduced or increased distance between any two of the touch points is greater than or equal to a preset value of distance variation.

Abstract: The present application relates to a photodetector based on interband transition in quantum wells. The photodetector may include a first semiconductor layer having a first conduction type; a second semiconductor layer having a second conduction type different from the first conduction type; and a photon absorption layer arranged between the first semiconductor layer and the second semiconductor layer, the photon absorption layer including at least one quantum well layer and barrier layers arranged on both sides of each quantum well layer. The present application utilizes the modulating effect of a semiconductor PN junction on a photoelectric conversion process associated with quantum wells to significantly increase a current output of the photodetector based on the quantum well material.

Abstract: The disclosure is related to a method and a device for displaying the execution status of an application. The method comprises receiving a non-touch instruction of the application; searching the application according to the instruction; and executing an operation with a specific display effect on the determined icon. The disclsoure further discloses a device for displaying the execution status of an application. The disclosure displays the non-touch instructions for the applications sent from users such that the user may understand the execution status sufficiently of the applications during usage.

Abstract: The invention provides a load balancer (300) and a system (200) comprising a load balancer for use in a computer network and for distributing network traffic between one or more of a plurality of traffic servers (206a-c). The load balancer comprises an external receiver (305) configured to receive data packets from a client side (216) and/or a server side (218). The load balancer comprises a traffic scheduler (314) configured to determine a traffic server to which a received data packet is to be transmitted. The load balancer comprises an internal transmitter (302) configured to transmit the data packet to the determined traffic server. If the data packet is received from the client side, the traffic scheduler is configured to determine the traffic server based on a source network address for the data packet. If the data packet is received from the server side, the traffic scheduler is configured to determine the traffic server based a destination network address for the data packet.

Abstract: The invention discloses a data transmission method, device and system. The data transmission method comprises: determining that a connection is established between a first terminal and a second terminal; obtaining identification information of a first client disposed in the first terminal; and transmitting the identification information to a second client disposed in the second terminal. By employing the invention, the problem can be solved in which since data transmission can not be conducted between different clients, user requirements must be re-introduced when a new client is enabled, thereby resulting in resource waste and low efficiency.

Abstract: A method for synthesizing and screening a lead compound, comprising the following steps: (1) retrieving raw materials: retrieving an i-number of synthetic blocks and an (i+2)-number of single-stranded DNA fragments; (2) synthesizing a compound by using a combinatorial chemistry method, acquiring a library of a single-stranded DNA-marked compound; (3) screening: screening the library of the DNA-marked compound; and, (4) sequencing: retrieving the DNA-marked compound screened in step (3), and sequencing the DNA on the DNA-marked compound, where the synthesis blocks and reaction mechanism of the compound can be determined on the basis of the DNA sequencing. Also disclosed are a synthesis and screening reagent testing kit for the lead compound and a combinatorial chemistry library.

Abstract: The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [?]D=?52°˜?57° in the solution of 0.02 g/ml chloroform at temperature of 25° C. The present invention also relates to the crystalline compound of isovalerylspiramycin III, II or I in levocarrimycin, and pharmaceutical compositions containing the said levocarrimycin.

Abstract: Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection.

Abstract: A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, including the steps of: (a) constructing a recombinant plasmid including a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I-producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively including a single gene ist.

Abstract: The invention discloses compositions, including nutritional products and dietary supplements, comprising aegeline, which is a compound that occurs naturally in the Bael plant. The invention also describes methods comprising the administration of aegeline to mammals. The methods result in increased mental stamina, focus, and energy level, improved mood, increased thermogenesis, increased libido, and anabolic effects and increased strength output and/or muscle mass. These effects can improve cognition, influence body composition, promote weight loss, and/or promote fitness and well-being. A novel method for the synthesis of aegeline is also provided.

Abstract: The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [?]D=?52°˜?57° in the solution of 0.02 g/ml chloroform at temperature of 25° C. The present invention also relates to the crystalline compound of isovalerylspiramycin III, II or I in levocarrimycin, and pharmaceutical compositions containing the said levocarrimycin.

Abstract: A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, comprising the steps of: (a) constructing a recombinant plasmid comprising a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I—producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively comprising a single gene ist.

Abstract: A read only memory (ROM) and an operating method thereof are provided. The read only memory includes: a control circuit, powered by a first power source for outputting a control signal within a first voltage range; a voltage shifter, for expanding the amplitude of the control signal to a second voltage range; a word line driver, powered by a second power source with a voltage which is higher than that of the first power source, for driving one of a plurality of word lines of a read only memory cell array according to the control signal which is expanded to be within the second voltage range; and an input/output circuit, for connecting the plurality of bit lines to read out messages.