Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: A photolithographic apparatus includes a particle removing cassette, a pump and a compressor. The particle removing cassette includes a first slit that includes an array of parallel wind blade nozzles arranged along a length of the first slit, protruding from the first slit, and configured to eject and direct pressurized cleaning material to a patterning surface of a mask to remove debris particles on the patterning surface. The pump and the compressor are controlled by a controller to adjust a flow rate and a pressure of the pressurized cleaning material based on an amount of debris particles on the patterning surface of the mask.

Abstract: Provided is a communication method. The method includes: receiving, by a first station (STA), a block acknowledgement (BA) frame, wherein the BA frame carries first information and/or protected privacy-related information, the first information being configured to identify the protected privacy-related information.

Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: A method of manufacturing a semiconductor device includes forming a photoresist layer on a target layer. The photoresist layer includes a polymer including first repeating units and second repeating units, the first repeating units are and the second repeating units are selected from the group consisting of X1 and X3 are respectively an arylene group. X5, X8, and X11 are respectively a trivalent functional group derived from an arene by removal of three hydrogen atoms. X2, X6, X7, X10, —X4—OH, —X9—OH, —X12—OH, and —X13—OH are respectively an acid labile group. R1, R2, R3, R4, and R5 are respectively hydrogen or a methyl group. The photoresist layer is selectively exposed to a radiation. The photoresist layer is developed to form a patterned photoresist layer. The target layer is etched by using the patterned photoresist layer as an etching mask.

Abstract: The present disclosure provides multivalent anti-spike protein binding molecules. The present disclosure further relates to the methods of producing the multivalent anti-spike protein binding molecules, pharmaceutical compositions comprising of the multivalent anti-spike protein binding molecules, and methods of use of the multivalent anti-spike protein binding molecules, e.g., to treat conditions associated with SARS-CoV and SARS-CoV-2 infections, such as COVID-19.

Abstract: The present disclosure relates to multispecific molecules comprising a peptide-MHC complex and an immune cell antigen targeting moiety. Particular aspects relate to multimeric (e.g., dimeric) molecules comprising a peptide-MHC complex, an immune cell antigen targeting moiety, and a multimerization moiety. The disclosure further provides pharmaceutical compositions comprising the multispecific molecules, and methods of use of multispecific molecules in antigen-specific T cell activation, in inducing an antigen-specific immune response, and in therapeutic applications, as well as nucleic acids encoding the multispecific molecules, recombinant cells that express the multispecific molecules, and methods of producing the multispecific molecules.

Abstract: Provided is a communication method. The method includes: receiving, by a first station (STA), a control frame carrying first information and/or second information, wherein the first information is configured to identify the second information, and the second information comprises protected information.

Abstract: A photoresist composition includes a photoactive compound and a polymer. The polymer has a polymer backbone including one or more groups selected from: The polymer backbone includes at least one group selected from B, C-1, or C-2, wherein ALG is an acid labile group, and X is a linking group.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: Mass transfer equipment including a base stage, a first substrate stage, a second substrate stage, at least one laser head and a servo motor module is provided. The first substrate stage is adapted to drive a target substrate to move along a first direction. The second substrate stage is adapted to drive at least one micro device substrate to move along a second direction. The at least one laser head is adapted to move to a target position of the second substrate stage and emits a laser beam toward the at least one micro device substrate. At least one micro device is separated from a substrate of the at least one micro device substrate and connected with the target substrate after the irradiation of the laser beam. The servo motor module is used for driving the first substrate stage, the second substrate stage and the at least one laser head to move.

Abstract: The present disclosure provides ACE2 fusion proteins, comprising multimerization moieties linked to ACE2 moieties, that specifically bind to RBD regions of SARS-CoV and/or SARS-CoV-2. The present disclosure further relates to the methods of producing the ACE2 fusion proteins, pharmaceutical compositions comprising of the ACE2 fusion proteins, and methods of use of the ACE2 fusion proteins to treat conditions associated with SARS-CoV and SARS-CoV-2 infections, such as COVID-19.

Abstract: According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the target antigen with an EC50 of about 10 nM or less, and/or are capable of promoting complement deposition on the target antigen with an EC50 of about 10 nM. In certain embodiments, the bispecific antigen-binding molecules of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of an infectious agent or cancer cell is desired and/or therapeutically beneficial.

Abstract: An earthquake detection method is disclosed. The method comprises the following steps: receiving a first signal and at least a second signal, wherein the first signal is triggered in response to a first vibration state of a main detection site, and the at least a second signal is triggered in response to at least a second vibration state of at least a backup detection site; determining whether a quantity of those being enabled among the at least a second signal satisfies a quantity ratio condition, and determining whether the first signal and the quantity of the at least a second signal are both enabled at a specific time point, wherein the first and the quantity of the at least a second signals respectively have a first and at least a second initial enabled time points; and determining there is a real earthquake event when an interval between the first and the at least a second signal satisfies a time relationship.

Abstract: A method for predicting an on-site seismic feature value using artificial intelligence is disclosed. The method includes the steps of obtaining a plurality of seismic historical data for a local position, wherein each of the seismic historical data includes seismic longitudinal wave information and a corresponding seismic transverse wave feature value, the seismic longitudinal wave information includes a plurality of data related to a vertical direction of ground surface, and the plurality of data include at least an acceleration value, a displacement value, a period and a velocity value; and based on at least the plurality of seismic historical data, obtaining a seismic transverse wave prediction model for the local position via an artificial intelligence calculation module.

Abstract: The present disclosure relates to molecules capable of binding to FGFR3 and methods of use thereof.

Abstract: An information platform for providing an earthquake early warning of a large area is disclosed. The large area includes a plurality of small districts, different sets of the plurality of small districts form different large districts according to geographical locations so as to make up the large area, and the information platform is both connected with a plurality of on-site earthquake early warning stations and the plurality of small districts through a cloud network. The plurality of on-site earthquake early warning stations are located in the large districts respectively, each of the plurality of on-site earthquake early warning stations is configured to obtain a real-time seismic longitudinal wave measurement data, obtain a real-time seismic transverse wave feature prediction value corresponding to the real-time seismic longitudinal wave measurement data, and transmit the real-time seismic transverse wave feature prediction value.

Abstract: An on-site earthquake early warning method is disclosed. The method includes the following steps: receiving a first signal generated in response to a first vibration event and a second signal generated in response to a second vibration event; determining whether an earthquake event exists according to the first and the second signals; predicting a real-time seismic shear wave prediction characteristic value according to the first signal; and sending the real-time seismic shear wave prediction characteristic value when it is determined that the earthquake event exists.