Abstract: Disclosed herein are monospecific and bispecific antibodies that comprise a ALPPL2/ALPP-binding variable region. The bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (ALPPL2/ALPP) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., CD3) expressed by immune effector cells.

Abstract: The disclosure includes methods and an apparatus that includes processing circuitry that selects at least one candidate surrogate metric from a plurality of surrogate metrics based on first testing data of a target metric and the plurality of surrogate metrics from a first database in memory. The first testing data have been generated from previously controlled testing of a control variant and a treatment variant of a feature of a webpage or a computer application. The processing circuitry determines current testing results associated with the plurality of surrogate metrics and determines an output of the current controlled testing based on one or more of the current testing results associated with the at least one candidate surrogate metric. If the output indicates the treatment variant replacing the control variant of the feature of the webpage or the computer application, the control variant is replaced with the treatment variant of the feature.

Abstract: The present application provides a lyophilized bead pre-embedding structure, a digital microfluidic chip, and a pre-embedding and liquid injection method. The present application realizes normal-temperature transportation of the digital microfluidic chip, saves the transportation cost, and improves the stability and reliability of chip reagent pre-embedding.

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing a security model to customizable live applications in a cloud collaboration platform. The security approach may dedicate a frame to each live application, serving the frame from a different domain than a document in which the live application is embedded. This approach ensures that more stringent security requirements may be required of the live application and allows the data presented to the live application to be narrowly tailored. The security model may further leverage sandbox attributes and content-security policies to restrict the behavior of sandboxed and non-sandboxed live applications in accordance with best security practices.

Abstract: A reagent pre-embedding and sample injecting device, and a sample injection method therefor and application thereof. The reagent pre-embedding and sample injecting device comprises a reagent container for sealing and storing a reagent, and a sample injection seat. The sample injection seat has a cavity structure, a bottom liquid-outputting end, and a liquid injection column. The reagent container is arranged at a top open end of the cavity structure. The bottom liquid-outputting end is used for extending into a gap cavity of a digital micro-fluidic chip. The liquid injection column is arranged at the bottom of the cavity structure, and the end of the liquid injection column is provided with a puncturing component for puncturing the reagent container, such that the reagent in the reagent container flows into the gap cavity of the digital micro-fluidic chip from the bottom liquid-outputting end of the sample injection seat.

Abstract: A curing agent comprising a polyetheramine, a tertiary amine and an alkanolamine. The curing agent may be combined with an epoxy resin to form a curable composition which is capable of being applied to a substrate and cured to form a cured article.

Abstract: Leave-on oral care compositions having good spreadability and improved retention property are provided for promoting Gum Health of a user. Leave-on oral care compositions can comprise a hyaluronic acid or a salt thereof, a polyacrylic acid as a mucoadhesive polymer, and an additional polymer.

Abstract: A microfluidic chip, wherein the microfluidic chip comprises a microfluidic chip substrate, a conductive cover and a liquid injection housing, wherein the liquid injection housing is provided with at least one liquid injection conduit and an oil intake conduit; wherein the liquid injection housing comprises an oil injection cavity, a sample dosing cavity, and at least one liquid injection cavity; a liquid injection column connected to a corresponding one of the at least one liquid injection conduit is arranged respectively in each of the at least one liquid injection cavity, and each of the at least one liquid injection conduit forms a liquid injection channel; an oil injection column is arranged in the oil injection cavity and is connected to the oil intake conduit; and surfaces of the oil injection cavity and the at least one liquid injection cavity are each correspondingly provided with a spike component.

Abstract: A system device and method for quantitatively injecting a tested sample into a chip, and a use. The system device is used for injecting a quantitative tested sample into a gap chamber of a chip; the system device comprises a sample quantification assembly and a liquid injection chamber; the sample quantification assembly comprises a body; a quantitative chamber is provided in the body; the liquid injection chamber comprises an open housing; a partition plate is provided in the housing; the partition plate divides the housing into a first chamber and a second chamber; the tested sample is injected into the first chamber; the sample quantification assembly is placed in the liquid injection chamber and is continuously pressed down; the body extends into the first chamber for quantitative injection.

Abstract: A pixel structure includes a first light-emitting diode for emitting a first light, wherein the first light-emitting diode has a first semiconductor layer, a first light-emitting surface, and a first electrode under the first semiconductor layer away from the first light-emitting surface; a second light-emitting diode for emitting a second light, wherein the second light-emitting diode has a second semiconductor layer, a second light-emitting surface, and a second electrode under the second semiconductor layer away from the second light-emitting surface; a dielectric layer surrounding and contacting the first semiconductor layer and the second light-emitting diode and exposing the first light-emitting surface, the first electrode, the second light-emitting surface and the second electrode; a common conductive structure having a semiconductor layer and a metal layer; and a light-transmitting conductive layer covering and electrical connecting the first light-emitting diode, the second light-emitting diode and

Abstract: Disclosed is a die-bonding method which provides a target substrate having a circuit structure with multiple electrical contacts and multiple semiconductor elements each semiconductor element having a pair of electrodes, arranges the multiple semiconductor elements on the target substrate with the pair of electrodes of each semiconductor element aligned with two corresponding electrical contacts of the target substrate, and applies at least one energy beam to join and electrically connect the at least one pair of electrodes of every at least one of the multiple semiconductor elements and the corresponding electrical contacts aligned therewith in a heating cycle by heat carried by the at least one energy beam in the heating cycle. The die-bonding method delivers scattering heated dots over the target substrate to avoid warpage of PCB and ensures high bonding strength between the semiconductor elements and the circuit structure of the target substrate.

Abstract: A method, an apparatus, an electronic device, and a computer-readable storage medium for detecting a wind turbine blade based on drone aerial photography are provided. The method includes: determining first initial three-dimensional position coordinates and a posture of a wind turbine; determining second initial three-dimensional coordinates of a first expected position with respect to a front shooting position of the wind turbine, based on the first initial three-dimensional position coordinates, the posture, and a preset distance; inputting the second initial three-dimensional coordinates of the first expected position into a flight control system of the drone, and controlling the drone to fly to the second initial three-dimensional coordinates based on a GPS system; and controlling the drone to track at least one first key point of blades of the wind turbine, and determining a three-dimensional movement trajectory of the first key point in a camera coordinate system.

Abstract: This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies.

Abstract: This application discloses an antenna gain apparatus and a communication device. The antenna gain apparatus includes a first guiding portion and a second guiding portion. The first guiding portion is configured to be disposed at one side of an antenna radiating element in a first direction; and the second guiding portion is disposed on the first guiding portion, where the second guiding portion is located at one side of the first guiding portion in the first direction, and a shape of the second guiding portion matches a shape of the antenna radiating element.

Abstract: A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody, an androgen signaling inhibitor (ASI), a STAT3 inhibitor and/or a glucocorticoid receptor agonist or modular (SEGRAM) are provided.

Abstract: A curing agent comprising a polyetheramine, a tertiary amine substantially free of an aromatic tertiary amine and glycerin. The curing agent may be combined with an epoxy resin to form a curable composition which is capable of being applied to a substrate and cured to form a cured article.

Abstract: Antibodies are provided herein that agonize Wnt signaling, do not compete with a Wnt ligand for LRP6 binding, and activate Wnt signaling in the presence of inhibitors. Methods for promoting cell differentiation and tissue regeneration using the disclosed antibodies are also provided.

Abstract: A blood sample platelet uniform-mixing device for a blood analyzer includes a vortex oscillation device, the vortex oscillation device includes a fixing assembly, a rotating assembly and a vibrating assembly. The fixing assembly is used for fixing sample test tubes. The rotating assembly includes a rotating motor and a rotating disc. A rotating shaft of the rotating motor is connected with the rotating disc, the rotating disc is matched with the fixing assembly. A central axis of each of the sample test tubes fixed on the fixing assembly deviates from the rotating shaft of the rotating motor. The rotating assembly is used for rotating the fixing assembly and making a blood sample in each of the sample test tubes be in a vortex shape. The vibrating assembly is arranged on the fixing assembly.

Abstract: A quartz crystal resonator including a quartz crystal obtained from a quartz bar is provided. The quartz bar has a light axis, an electrical axis along a length of the quartz bar, and a mechanical axis that are perpendicular to one another. The quartz crystal has a major face cut from the quartz bar along a cutting plane. The cutting plane has a first angle of about 35° to about 36° with the light axis and has a second angle with the electric axis. The first angle is obtained by rotation about the electric axis, and the second angle is obtained by rotation about the light axis, such that the quartz crystal has a vibration frequency deviation inflection point in a range from about 30° C. to about 45° C. Methods for making the quartz crystal are also provided.