Abstract: A power converter includes a plurality of direct current-direct current (DC-DC) power conversion circuits that are connected in series. And a controller is configured to: send a first pulse signal to control a first DC-DC power conversion circuit to work, and send a second pulse signal to control a second DC-DC power conversion circuit to work, to enable a direct current busbar to charge a battery pack, or enable a battery pack to be discharged to a direct current busbar. A duty cycle of the first pulse signal is determined based on a voltage or a current at a first end of the power converter, or a voltage or a current at a second end of the power converter. The second pulse signal has a fixed duty cycle and a fixed frequency.

Abstract: A microfluidic chip and a preparation method therefor, and a microfluidic system The microfluidic chip includes a first substrate a second substrate, and a gap control layer located between the first substrate and the second substrate wherein the gap control layer comprises an adhesive line and a plurality of gap beads of substantially the same size arranged at intervals in the adhesive line.

Abstract: Disclosed herein are anti-CD38 antibodies, anti-ICAM1 antibodies, pharmaceutical compositions comprising anti-CD38 antibodies and/or anti-ICAM1 antibodies, and methods of use for the treatment of a proliferative disease. In certain embodiments, also disclosed herein are multi-specific antibodies (e.g., bispecific antibodies) comprising a first targeting moiety that specifically binds to CD38 and a second targeting moiety that specifically binds to ICAM1, pharmaceutical compositions comprising the multi-specific antibodies, and methods of use for the treatment of a proliferative disease.

Abstract: The present invention relates to the field of drilling coring devices. Disclosed are a pressure-preserved coring tool, a use method, and a reservoir analysis method. The pressure-preserved coring tool comprises an outer cylinder (1), a differential assembly (2), a pressure-preserving inner cylinder assembly (4), and a seal assembly (5). The differential assembly is configured to be able to drive the pressure-pre-serving inner cylinder assembly to move upwards relative to the seal assembly, so that the seal assembly seals the inner cylinder assembly for accommodating a rock core (8).

Abstract: A thin film, a digital microfluidic chip substrate, and a preparation method therefor. The thin film (3) is a dielectric and hydrophobic thin film, one surface of the dielectric and hydrophobic thin film being a hydrophilic surface, and the other surface of the dielectric and hydrophobic thin film being a hydrophobic surface. The thin film (3) has both dielectric and hydrophobic functions, thus radically overcoming the irreversible damage to traditional digital microfluidic chips caused by hydrophobic layers thereof falling off from dielectric layers, and greatly simplifying the preparation process for dielectric and hydrophobic layers. Meanwhile, the thin film is resistant to high temperature and does not easily fall off from the circuit substrate (1), thereby widening the use scenarios of a chip, and prolonging the service life of the chip.

Abstract: Leave-on oral care compositions comprising a hyaluronic acid and a gum-strengthening polyol are provided for promoting Gum Health of a user.

Abstract: Provided is a rare earth magnesium alloy based on high-temperature and high-pressure hydrogenation and a preparation method thereof, which belongs to the technical field of alloy materials. In the present disclosure, a microstructure of a rare earth magnesium alloy is regulated based on high-temperature and high-pressure hydrogenation to significantly improve the plasticity of the rare earth magnesium alloy. A similar microstructure can also be achieved in other high-gadolinium (Gd) and high-yttrium (Y) systems. The present disclosure provides a unique approach to enhance the plasticity of a magnesium alloy, and makes it more likely to regulate the mechanical properties of such a rare earth alloy subsequently through other deformation processes. The rare earth magnesium alloy based on high-temperature and high-pressure hydrogenation can be used for neutron-shielding, and is a material with a structure-function integrated design that can be used in the nuclear energy field and space field.

Abstract: In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

Abstract: Provided is a rare earth magnesium alloy based on high-temperature and high-pressure hydrogenation and a preparation method thereof, which belongs to the technical field of alloy materials. In the present disclosure, a microstructure of a rare earth magnesium alloy is regulated based on high-temperature and high-pressure hydrogenation to significantly improve the plasticity of the rare earth magnesium alloy. A similar microstructure can also be achieved in other high-gadolinium (Gd) and high-yttrium (Y) systems. The present disclosure provides a unique approach to enhance the plasticity of a magnesium alloy, and makes it more likely to regulate the mechanical properties of such a rare earth alloy subsequently through other deformation processes. The rare earth magnesium alloy based on high-temperature and high-pressure hydrogenation can be used for neutron-shielding, and is a material with a structure-function integrated design that can be used in the nuclear energy field and space field.

Abstract: Leave-on oral care compositions including a hyaluronic acid or a salt thereof good spreadability and improved retention period are provided for promoting Gum Health of a user. Kits and methods are also provided.

Abstract: A high-shear mixing chamber is provided having a single wide slot microchannel that enables a higher throughput, less plugging, and a longer life (e.g., less wear) than typical multi-slotted mixing chambers. The provided mixing chamber may include an inlet and an outlet in fluid communication with a single wide slot microchannel (e.g., via an inlet and outlet plenum). In some aspects, the wide slot microchannel may have a stepped interior such that the wide slot microchannel has portions with different depths. The wide slot microchannel has a first surface opposite a second surface and one or more steps may be formed with the first surface alone, the second surface alone, or with both the first surface and the second surface. The steps may extend a full length of the microchannel between the inlet and outlet chambers.

Abstract: Methods and apparatus for fault isolation with scanning electron microscope probing are disclosed. An example apparatus to test a circuit includes interface circuitry operatively coupled to an electron detector, the electron detector to output a signal corresponding to electron emissions from the circuit as the circuit is driven with a signal source and the circuit is rastered with an electron beam, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to demodulate the signal, and generate an image based on the demodulated signal for determination of a condition of the circuit.

Abstract: In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

Abstract: This application discloses an antenna gain apparatus and a communication device. The antenna gain apparatus includes a first guiding portion and a second guiding portion. The first guiding portion is configured to be disposed at one side of an antenna radiating element in a first direction; and the second guiding portion is disposed on the first guiding portion, where the second guiding portion is located at one side of the first guiding portion in the first direction, and a shape of the second guiding portion matches a shape of the antenna radiating element.

Abstract: Disclosed herein are monospecific and bispecific antibodies that comprise a ALPPL2/ALPP-binding variable region. The bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (ALPPL2/ALPP) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., CD3) expressed by immune effector cells.

Abstract: The present application provides a lyophilized bead pre-embedding structure, a digital microfluidic chip, and a pre-embedding and liquid injection method. The present application realizes normal-temperature transportation of the digital microfluidic chip, saves the transportation cost, and improves the stability and reliability of chip reagent pre-embedding.

Abstract: The disclosure includes methods and an apparatus that includes processing circuitry that selects at least one candidate surrogate metric from a plurality of surrogate metrics based on first testing data of a target metric and the plurality of surrogate metrics from a first database in memory. The first testing data have been generated from previously controlled testing of a control variant and a treatment variant of a feature of a webpage or a computer application. The processing circuitry determines current testing results associated with the plurality of surrogate metrics and determines an output of the current controlled testing based on one or more of the current testing results associated with the at least one candidate surrogate metric. If the output indicates the treatment variant replacing the control variant of the feature of the webpage or the computer application, the control variant is replaced with the treatment variant of the feature.

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing a security model to customizable live applications in a cloud collaboration platform. The security approach may dedicate a frame to each live application, serving the frame from a different domain than a document in which the live application is embedded. This approach ensures that more stringent security requirements may be required of the live application and allows the data presented to the live application to be narrowly tailored. The security model may further leverage sandbox attributes and content-security policies to restrict the behavior of sandboxed and non-sandboxed live applications in accordance with best security practices.

Abstract: A reagent pre-embedding and sample injecting device, and a sample injection method therefor and application thereof. The reagent pre-embedding and sample injecting device comprises a reagent container for sealing and storing a reagent, and a sample injection seat. The sample injection seat has a cavity structure, a bottom liquid-outputting end, and a liquid injection column. The reagent container is arranged at a top open end of the cavity structure. The bottom liquid-outputting end is used for extending into a gap cavity of a digital micro-fluidic chip. The liquid injection column is arranged at the bottom of the cavity structure, and the end of the liquid injection column is provided with a puncturing component for puncturing the reagent container, such that the reagent in the reagent container flows into the gap cavity of the digital micro-fluidic chip from the bottom liquid-outputting end of the sample injection seat.