Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

Abstract: Disclosed are bio-based mono-ethylene glycol (MEG) compositions containing from about 1 ppm to about 5000 ppm of at least one C3-C12 1,2-diol, bio-based polyester compositions made therefrom, and methods of making the same are disclosed. Preforms and blow-molded polyester containers prepared from the bio-based MEG and polyester are described.

Abstract: A spectrally-resolved Raman water lidar, including: a transmitter unit, a receiver unit, and a data acquisition and control unit. The transmitter unit includes a seeder, a solid Neodymium-doped Yttrium Aluminum Garnet (Nd: YAG) laser, a beam expander, and a first reflecting mirror to emit a 354.8-nm laser beam. The receiver unit includes a telescope, an iris, a collimator, a second reflecting mirror, a first bandpass filter, a beam splitter, a narrow-band interference filter, a third lens, a first detector, a second bandpass filter, a coupler and a home-made dual-grating polychromator to enable simultaneous profiling of backscattered Raman spectrum signals from water vapor, water droplets and ice crystals as well as aerosol fluorescence in the atmosphere. The data acquisition and control unit includes a computer to store the acquired data and guarantee an automatic operation of the lidar system through a time-sequence circuit.

Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

Abstract: A single-line-extracted pure rotational Raman lidar system, including: a transmitter unit configured to emit extremely narrow-band laser light that is guided into atmosphere zenithward; a receiver unit configured to collect backscattered signals from the atmosphere; and a data acquisition and control unit configured to deliver data and guarantee automatic operation of the lidar system orderly. The transmitter unit employs a powerful injection-seeded Nd: YAG laser to emit 532.23 nm laser beam with a pulse energy of approximately 800 mJ, a repetition rate of 30 Hz and linewidth of <0.006 cm?1. The lidar system has an optical bandwidth of approximately 30 pm for the two Raman channels and an optical bandwidth of 0.3 nm for an elastic channel, as well as a field of view of approximately 0.4 mrad. The two Raman channels extract the N2 anti-Stokes pure rotational Raman line signals with J=6 and 16, respectively.

Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.

Abstract: A method and apparatus are disclosed for identifying malicious software in the technical field of computers. The method includes: obtaining, according to a source code of to-be-detected software, a function call diagram of the software; generating a feature sequence of the software according to the function call diagram, the feature sequence including an eigenvalue of at least one feature, the feature being a function in a preset function library, and the eigenvalue of the feature being a quantity of times of calling of the function by the software; and identifying whether the software is malicious software according to the feature sequence and a random forest, the random forest including at least one decision tree, and the decision tree including reference eigenvalues of multiple features. The apparatus includes: an obtaining module, a generation module, and an identification module.

Abstract: A composition for medical usage and method of preparing the same are provided. The composition comprises: at least one magnetic nanoparticle including a nanodiamond particle and at least one magnetic element, wherein the at least one magnetic element is embedded into the at least one nanodiamond particle by using an ion implantation system. The nanodimond particle can be synthesized with different components which can help medical effects of the composition.

Abstract: A fiber optic connector includes: a housing and an integrated ferrule assembly. N positioning keys are formed on an outer periphery of a ferrule tail seat of the ferrule, wherein N is an integer equal to or greater than two, the N positioning keys are spaced at an equal angle around the outer periphery of the ferrule tail seat, and one of the N positioning keys corresponding to an eccentric orientation of an optical fiber secured in the ferrule is cut out to form a cutting portion; (N?1) positioning slots, which correspond to (N?1) positioning keys on the ferrule tail seat, respectively, are formed in the housing, and there is no positioning slot formed in a part of the housing corresponding to the cutting portion, such that the integrated ferrule assembly may be inserted into the housing only when the N?1 positioning keys are aligned with the (N?1) positioning slots respectively.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus, and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.

Abstract: The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.

Abstract: A method of testing large-scale integrated circuits including multiple instances of memory arrays, and an integrated circuit structure for assisting such testing. In one embodiment, voltage drops due to parasitic resistance in array bias conductors are determined by extracting layout parameters, and subsequent circuit simulation that derives the voltage drops in those conductors during operation of each memory array. In another embodiment, sense lines from each memory array are selectively connected to a test sense terminal of the integrated circuit, at which the array bias voltage at each memory array is externally measured. Feedback control of the applied voltage to arrive at the desired array bias voltage can be performed.

Abstract: A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus, and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.

Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

Abstract: A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, ?or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.

Abstract: The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.

Abstract: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models.

Abstract: Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.

Abstract: A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, ?or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.