Abstract: The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.

Abstract: Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.

Abstract: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models.

Abstract: The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in <Formula 1>, have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.

Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.

Abstract: The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

Abstract: The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.

Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.

Abstract: A fabrication method for a liquid crystal display. A pair of substrates is provided. An alignment layer is formed on the respective substrates. An energy beam is irradiated on a predetermined area of at least one of the alignment layers. The alignment layer is rubbed to form a first pretilt-angle area in the predetermined area exposed to the energy beam, and a second pretilt-angle area not exposed to the energy beam. The pair of substrates are bonded with a preset gap therebetween, and a liquid crystal layer is inserted between the substrates. The liquid crystals corresponding to the first pretilt angle area have a first pretilt angle of ?1, while those corresponding to the second pretilt angle area have a second pretilt angle of ?2.

Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.

Abstract: A method of forming a transflective display device having a single cell gap in which a liquid crystal molecule has at least two pretilt angles. A transparent electrode is formed on the inner surface of the lower substrate, and a reflective electrode is formed on a portion of the transparent electrode. Thus, creating a reflective region over the reflective electrode, and a transmissive region over the transparent electrode which is not covered by the reflective electrode. Using a photo-alignment process to form at least two alignment domains on each of the two alignment layers sandwiching a liquid crystal layer, the pretilt angle of the liquid crystal molecule in the reflective region is different from the pretilt angle of the liquid crystal molecule in the transmissive region, the reflective region and the transmissive region have the same phase retardation, and the light path passing through the reflective region is twice the light path passing through the transmissive region.

Abstract: A fabrication method for a liquid crystal display. A pair of substrates is provided. An alignment layer is formed on the respective substrates. An energy beam is irradiated on a predetermined area of at least one of the alignment layers. The alignment layer is rubbed to form a first pretilt-angle area in the predetermined area exposed to the energy beam, and a second pretilt-angle area not exposed to the energy beam. The pair of substrates are bonded with a preset gap therebetween, and a liquid crystal layer is inserted between the substrates. The liquid crystals corresponding to the first pretilt angle area have a first pretilt angle of ?1, while those corresponding to the second pretilt angle area have a second pretilt angle of ?2.

Abstract: Flexible article having sense of touch and method of manufacturing same is disclosed. The article comprises a hollow member formed by injection molding of TPR, and a jellylike substance filled in the hollow member, the jellylike substance being formed from PVA solution. Preferably, the PVA solution is comprised of 3 wt % to 30 wt % PVA, 20 wt % to 85 wt % water, 0.5 wt % to 10 wt % plasticizer, and 0 wt % to 20 wt % softness enhancing additive.

Abstract: A polymer gel display, fabrication method and operating structure thereof. Display is enabled by utilizing the flexing characteristic of a polymer-gel sheet. A pair of substrates is separated by a predetermined gap, and a polymer-gel sheet of a first color disposed therebetween, having two ends fixed, a center area flexible and contacting no more than one of the substrates. A fluid layer of a second color is disposed between the substrates, displaying its color via the substrate not contacting the polymer-gel sheet. An external electric field is applied to the polymer-gel sheet, flexing the polymer-gel sheet toward the substrate until making contact and the first color of the polymer-gel sheet is displayed via the substrate.

Abstract: A transflective display device having a single cell gap in which a liquid crystal molecule has at least two pretilt angles. A transparent electrode is formed on the inner surface of the lower substrate, and a reflective electrode is formed on a portion of the transparent electrode, such that a reflective region is over the reflective electrode and a transmissive region is over the transparent electrode, which is not covered by the reflective electrode. The pretilt angle of the liquid crystal molecule in the reflective region is different from the pretilt angle of the liquid crystal molecule in the transmissive region, the reflective region and the transmissive region have the same phase retardation, and the light path through the reflective region is twice the light path passing through the transmissive region.

Abstract: A transflective display device has a single cell gap in which a liquid crystal molecule has at least two pretilt angles. A transparent electrode is formed on the inner surface of the lower substrate, and a reflective electrode is formed on a portion of the transparent electrode. Thus, creating a reflective region over the reflective electrode, and a transmissive region over the transparent electrode which is not covered by the reflective electrode. Using a photo-alignment process to form at least two alignment domains on each of the two alignment layers sandwiching a liquid crystal layer, the pretilt angle of the liquid crystal molecule in the reflective region is different from the pretilt angle of the liquid crystal molecule in the transmissive region, the reflective region and the transmissive region have the same phase retardation, and the light path passing through the reflective region is twice the light path passing through the transmissive region.

Abstract: A wide-viewing angle display device serves as a multi-domain vertical alignment (MVA) mode liquid crystal display (LCD) device or an in-plane switching (IPS) mode liquid crystal display (LCD) device. A plurality of protrusions is formed on the inner surface of the glass substrate, and an electrode array is formed on the tops of the protrusions. Thus, the electrodes are suspended in the liquid crystal cell gap, and a transverse electrical field is generated by the electrodes to drive the liquid crystal molecules.

Abstract: A method of relocating spacers using inductive attraction. A chuck employs the inductive attraction to lift field emission display (FED) spacers, wherein the spacers are provided with susceptibility to the employed attraction. The spacers are lifted by the chuck and relocated to a desired position. The inductive process uses a non-contact force, including electrostatic and magnetic forces.

Abstract: A transflective display device has a single cell gap in which a liquid crystal molecule has at least two pretilt angles. A transparent electrode is formed on the inner surface of the lower substrate, and a reflective electrode is formed on a portion of the transparent electrode. Thus, creating a reflective region over the reflective electrode, and a transmissive region over the transparent electrode which is not covered by the reflective electrode. Using a photo-alignment process to form at least two alignment domains on each of the two alignment layers sandwiching a liquid crystal layer, the pretilt angle of the liquid crystal molecule in the reflective region is different from the pretilt angle of the liquid crystal molecule in the transmissive region, the reflective region and the transmissive region have the same phase retardation, and the light path passing through the reflective region is twice the light path passing through the transmissive region.

Abstract: A wide-viewing angle display device serves as a multi-domain vertical alignment (MVA) mode liquid crystal display (LCD) device or an in-plane switching (IPS) mode liquid crystal display (LCD) device. A plurality of protrusions is formed on the inner surface of the glass substrate, and an electrode array is formed on the tops of the protrusions. Thus, the electrodes are suspended in the liquid crystal cell gap, and a transverse electrical field is generated by the electrodes to drive the liquid crystal molecules.