Abstract: A display substrate and a display device are provided, the display substrate includes a base substrate and a circuit structure layer disposed on the base substrate, the circuit structure layer includes a pixel circuit, a light emitting drive circuit, a scan drive circuit, a control drive circuit and a buffer drive circuit; the pixel circuit includes a node reset transistor, a writing transistor, a reset signal line connected to a control electrode of the node reset transistor, a scan signal line connected to a control electrode of the writing transistor, and a control signal line.

Abstract: Disclosed are a droplet generation method, system and application thereof. The method breaks through the limitation that the existing nanoliter scale droplet generation technology must use micro-channels below 0.1 mm, and can realize the preparation of small-volume uniform droplets at a reduced cost. The system includes a droplet generation device and a droplet receiver, the droplet generation device includes an accommodating cavity with a variable volume, a control mechanism for controlling the volume of the accommodating cavity to change periodically, and a droplet generation tube, which has a wide range of applications in clinical diagnosis, gene expression analysis, microorganism detection and other fields.

Abstract: A display substrate and a display apparatus. In the display substrate, the first signal line sequentially passes through the first display region, the opening peripheral region and the second display region along a first direction, and includes a first lead line portion and a first winding portion that are in the opening peripheral region and connected to each other; the first winding portion partially surrounds the opening; the second signal line provides a second display signal to the pixel array, passes through the peripheral region of the opening along a second direction intersecting with the first direction, includes a second winding portion in the peripheral region of the opening and partially surrounds the opening. The first lead line portion and the second signal line have a first overlapping region, and the first winding portion and the second winding portion have a second overlapping region.

Abstract: Provided are a pharmaceutical composition of a compound of formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical formulation thereof; and a preparation method for the pharmaceutical composition and the pharmaceutical formulation, and use of the pharmaceutical composition and the pharmaceutical formulation in the preparation of a medicament for treating an AAK1-induced related disease by inhibition or degradation of AAK1.

Abstract: Embodiments of the present disclosure provide a display panel. The display panel includes a base substrate, wherein the base substrate includes an opening region and a display region, the display region surrounding the opening region. The plurality of isolation pillars are disposed on a first surface of the base substrate, and the plurality of isolation pillars are circular and surround the opening region. The isolation pillars include a first pillar made of an insulating material, and an isolation groove surrounding the opening region is disposed at both sides of the first pillar.

Abstract: A general formula for lysins based on which the activity and functionality are further screened and 24 lysins are identified and further investigated, nine of which are characterized. These lysins exhibit potent bactericidal activity, capable of lysing multiple species of Staphylococcus, Streptococcus, and/or Enterococcus; demonstrate robust environmental resistance and stability, retaining activity under varying temperatures, NaCl concentrations, pH levels, and in immune serum; and effectively treat localized and systemic infections. These lysins and their variants are promising as antimicrobial agents for eradicating bacteria, preventing bacterial infections, or treating bacterial infections (caused by genera Staphylococcus, Streptococcus, and/or Enterococcus).

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: Provided are a display panel and a display device. The display panel includes: a via hole penetrating through the display panel; a cutting residual area on the periphery of the via hole and includes a base substrate, and a packaging layer: and at least one annular relief structure between the packaging laver and the base substrate in the cutting residual area. The at least one annular relief structure is sequentially distributed around the via hole. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, at least one of the surface and the side face is of a relief shape. The first relief structure is the relief structure with a smallest distance from the center of the via hole.

Abstract: The present invention discloses a bladder cancer detection kit and detection method. The kit includes a DHFR PCR reaction solution, a Twist1 and TSC21 PCR reaction solution, a point mutation positive control, a methylation positive control and a negative control. According to the present invention, by detecting the point mutation of a DHFR gene and the methylation level of a promoter region of TSC21 and Twist1 genes in a sample, the joint detection of gene point mutation and methylation is achieved for determining whether the sample is cancerous. The kit is convenient and simple to operate, high in detection sensitivity and high in specificity, and has a very positive significance in the detection of bladder cancer.

Abstract: Embodiments described herein generally relate to semiconductor device fabrication. More specifically, embodiments of the present disclosure relate to methods of forming a conformal liner on inner sidewalls of a via and/or a trench structure. The present disclosure generally provides a method of depositing a liner layer in a semiconductor structure. The method includes forming a passivation layer, forming a barrier layer, forming the liner layer, and filing the via and the trench with a conductive material. Forming the liner layer includes holding a precursor gas in a gas line upstream from a processing chamber behind a closed programmable logic control (PLC) valve, wherein the precursor gas is held behind the closed PLC valve for a PLC valve close period and releasing the precursor gas into the processing chamber by opening the PLC valve, wherein the precursor gas is released into the processing chamber for a PLC valve open period.

Abstract: The present invention provides liver cancer-associated serum microRNA markers and a new method for diagnosing liver cancer, wherein the liver cancer-associated serum microRNA markers consist of hsa-miR-122, hsa-miR-21, hsa-miR-2115, hsa-miR-221, hsa-miR-27 and hsa-miR-4499; relative expression level of the liver cancer-associated serum microRNA markers in serum is tested using Real-time PCR method, and reagents for the testing contains primers of the liver cancer-associated serum microRNA markers. The present invention can be used to diagnose hepatocellular carcinoma, in particular early hepatocellular carcinoma or to distinguish the serum of at least one patient with hepatocellular carcinoma from the serum of at least one healthy individual, the serum of at least one patient with chronic hepatitis B or the serum of at least one patient with liver cirrhosis.

Abstract: The present technology relates to systems and methods that allocate, arrange, and distribute certain types of functions and intelligence for autonomous driving systems (ADS) to facilitate vehicle operations and controls; to improve the safety of an autonomous vehicle (AV); and to ensure the efficiency, intelligence, reliability, and resilience of ADS. The present technology also provides methods to define ADS system intelligence and its levels, which are based on two dimensions: the vehicle intelligence and the cloud intelligence. The cloud intelligence supports and complements the vehicle intelligence when a vehicle is impaired or handicapped for certain functions (sensing, prediction, decision, and/or control) during operations in abnormal conditions. Distribution of driving intelligence between the AV and the cloud facilitates safe operations of the AV for long-tail corner cases.

Abstract: A shale gas formation oxidation induced rock burst stimulation method, the method including: performing hydraulic fracturing stimulation on a shale gas well to be fractured; and in the hydraulic fracturing process, injecting slick water A (f), oxidation fluid (e), slick water containing glue liquid (d), catalytic decomposition fluid (c), and slick water B (b) in a slug mode in sequence, and integrating shale physical characteristics and chemical thermodynamic properties to provide a fracturing fluid usage and the radius of the oxidation induced rock burst calculation formula. According to the method, the methane gas released by the shale gas formation after fracturing by the slick water A (f) is mixed with oxygen generated by the decomposition of hydrogen peroxide in the oxidation solution (e), and the shale gas formation is burst, such that the safe, efficient and damage-free multi-scale yield increasing stimulation of hydraulic fractures.

Abstract: Provided herein is technology relating to a distributed driving system with the support of an intelligent roadside toolbox (IRT) to address long-tail cases. The IRT comprises a cloud and provides fused data from multiple sensors and data sources. A connected automated vehicle (CAV) uses the fused data to supplement its sensing data and maintain its automation level when its components have failure. Moreover, the IRT predicts the movement and behavior of surrounding objects, pedestrians, and bicycles; and provides such vulnerable road user information to the CAV to help the CAV maintain its safe driving and desired autonomous driving level in complex urban environments. For emergency situations or function failure, the IRT provides emergency services and failure safety measures for the CAV.

Abstract: A display panel, including an active area and a peripheral area, which is located outside of the active area, wherein the active area comprises a base substrate, and a display structure layer and a touch structure layer sequentially arranged on the base substrate; the peripheral area includes an isolation dam, a first ground trace and a second ground trace arranged on the base substrate; and the first ground trace is located at a side of the isolation dam close to the active area, and the second ground trace is located at a side of the isolation dam away from the active area.

Abstract: The present invention pertains to the technical field of biomedical testing, and more specifically pertains to a kit and method for detecting methylation of genes in cervical cells. The present invention is used to determine whether a precancerous lesion occurs in a sample by detecting a methylation level of promoter regions of three genes MTHFR, PAX1 and SGSH in the sample, which is easy and convenient to operate, has high detection sensitivity and good specificity, and has a very positive significance for the detection of cervical cancer.

Abstract: Disclosed are a display substrate and a display apparatus. The display substrate includes a substrate, a plurality of sub-pixels, a plurality of first signal lines and a plurality of second signal lines, which are provided on the substrate, a sub-pixel includes a pixel circuit electrically connected with a first signal line, a first signal line includes at least one initial signal line, and a second signal line includes at least one initial connection line. The initial signal line extends along a first direction (D1), and the initial connection line extends along a second direction (D2), and the first direction (D1) intersects with the second direction (D2).

Abstract: This technology relates to autonomous vehicle (AV) control systems tailored for critical points with information support from a cloud platform or other vehicles. A first system integrates an onboard unit (OBU) and communication modules to interact with a cloud platform, delivering time-sensitive instructions to vehicles at critical points. The OBUs execute these instructions for driving tasks. A second system enables an AV to operate through critical points with information from other vehicles, leveraging integrated information services for enhanced functionality and safety. A third system combines an OBU with a cloud platform, leveraging cloud services for enhanced functionality, such as computing. The technology adapts to diverse critical point scenarios, employing proactive incident prediction and rapid detection methods for optimized performance.

Abstract: A probe sterilization device is provided. The probe sterilization device including: a housing defining a cavity with an opening, the housing including a cover plate capable of covering the opening; a cover plate drive, capable of driving, in response to a cover plate drive control signal, the cover plate to move so as to open the opening; a support, arranged in the housing and capable of fixing the probe; an ultraviolet light source, arranged in the housing and capable of being turned on in response to a light source control signal; and a processor, electrically connected to the cover plate drive and capable of sending the cover plate drive control signal to the cover plate drive, and electrically connected to the ultraviolet light source and capable of sending the light source control signal to the ultraviolet light source.

Abstract: A touch-control display panel is provided with a display region, a peripheral region and a lead-out region, wherein the peripheral region is located outside the display region; and the lead-out region is arranged outside the peripheral region in a column direction, and the lead-out region has a bonding portion for connecting to a flexible circuit board. The touch-control display panel includes a touch-control layer and a drive chip. The drive chip is provided with a touch-control pin group and gating circuits, wherein the touch-control pin group includes first touch-control pins, which include functional pins and dummy pins; and the touch-control layer is connected to the functional pins by means of touch-control leads, one functional pin being connected to one touch-control lead.