Abstract: Provided herein are novel compounds (e.g., Formula I), pharmaceutical compositions, and methods of using related to cyclin dependent kinases (CDKs). The compounds herein are typically CDK4 inhibitors, which can be used for treating a variety of diseases or disorders, such as cancer.

Abstract: The present disclosure includes a gas circulation device and a battery quiescence apparatus. The gas circulation device includes a first gas conveying assembly, a second gas conveying assembly, and an intake assembly. Working gas can be charged into the first gas storage tank and the second gas storage tank through the intake assembly, forming a pressure difference between the first gas storage tank and the second gas storage tank. When the first gas conveying assembly is opened, working gas in the first gas storage tank is conveyed to the quiescent chamber; when the first gas conveying assembly is closed and the second gas conveying assembly is opened, working gas in the second gas storage tank continues to be conveyed to the quiescent chamber until pressure in the quiescent chamber reaches a threshold.

Abstract: A display panel is provided, which includes a display region and a border region arranged around the display region. The display panel includes: a base substrate; a plurality of edge sub-pixels arranged on the base substrate, the plurality of edge sub-pixels being arranged at the edge of the display region and close to the border region, the edge sub-pixels including an anode pattern; a first initialization signal bus arranged on the base substrate, at least a part of the first initialization signal bus being arranged in the display region; wherein an orthographic projection of the anode pattern onto the base substrate overlaps an orthographic projection of the first initialization signal bus onto the base substrate at a first overlapping area.

Abstract: A display substrate and a display apparatus are provided. The display substrate comprises a base, a power signal line pattern, and a plurality of subpixels that each comprise an anode pattern, wherein the power signal line pattern comprises a first power line portion and a second power line portion; and at least a part of the first power line portion extends in a first direction; the plurality of subpixels comprise first and second subpixels, an overlap between the anode pattern of the first subpixel and the power signal line pattern is larger in area than an overlap between the anode pattern of the second subpixel and the power signal line pattern, and an overlap between the anode pattern of the first subpixel and the first power line portion is larger in area than an overlap between the anode pattern of the first subpixel and the second power line portion.

Abstract: The display panel includes: a via hole penetrating through the display panel; a cutting residual region, and a packaging layer located on one side of the base substrate; and at least one circle relief structure located between the packaging layer and the base substrate of the cutting residual region. The at least one circle relief structure is distributed around the via hole. The smallest distance between a first relief structure and the outer edge of the via hole ranges from 0 to 30 micrometers. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, where at least one of the surface and the side face is of a relief shape. The first relief structure is a relief structure with a smallest distance from a center of the via hole.

Abstract: Provided are a malware detection method and related apparatus. In the method, a dump file is obtained from a packed file, and then analysis and detection can be performed on the dump file to determine whether the dump file includes malware. The malware detection is based on analysis and detection for the dump file. In this way, the malware detection accuracy can be improved compared with static analysis detection, and the malware detection efficiency can be improved compared with pure dynamic analysis detection (e.g., running the packed file).

Abstract: A hand-held band saw includes a band saw body and an supporting device. The supporting device includes a fixing member, a slider, a supporting member, and a connection assembly. The fixing member is fixedly connected to the band saw body, the slider is slidably connected to the fixing member, the supporting member supports a workpiece and is connected to the slider, and the connection assembly connects the slider and the supporting member. When the slider moves, the connection assembly is capable of enabling the supporting member to move along with the slider. The connection assembly comprises a buffer member mounted between the slider and the supporting member.

Abstract: A fusion positioning method, comprising: sampling an environmental object by means of a two-dimensional laser radar carried by a robot, so as to acquire radar point cloud-related data of the environmental object; performing adjacent matching on the position Pi of a landmark Li in the environmental object on a road sign map and the landmark map, so as to acquire the position Pj of a landmark Lj nearest to the position Pi on the landmark map; performing scan matching on a two-dimensional grid map by using point cloud data, from which distortion is removed, of the environmental object, so as to acquire a global pose of the robot in the two-dimensional grid map, and taking same as a global pose observation value G pose of the robot; and according the position Pi of the landmark Li on the landmark map, the position Pj of the landmark Lj on the landmark map, and an estimated pose and the global pose observation value G pose of the robot, performing an iterative optimization on the pose of the robot until the error

Abstract: A display substrate and a display device are provided, the display substrate includes a base substrate and a circuit structure layer disposed on the base substrate, the circuit structure layer includes a pixel circuit, a light emitting drive circuit, a scan drive circuit, a control drive circuit and a buffer drive circuit; the pixel circuit includes a node reset transistor, a writing transistor, a reset signal line connected to a control electrode of the node reset transistor, a scan signal line connected to a control electrode of the writing transistor, and a control signal line.

Abstract: Disclosed are a droplet generation method, system and application thereof. The method breaks through the limitation that the existing nanoliter scale droplet generation technology must use micro-channels below 0.1 mm, and can realize the preparation of small-volume uniform droplets at a reduced cost. The system includes a droplet generation device and a droplet receiver, the droplet generation device includes an accommodating cavity with a variable volume, a control mechanism for controlling the volume of the accommodating cavity to change periodically, and a droplet generation tube, which has a wide range of applications in clinical diagnosis, gene expression analysis, microorganism detection and other fields.

Abstract: A display substrate and a display apparatus. In the display substrate, the first signal line sequentially passes through the first display region, the opening peripheral region and the second display region along a first direction, and includes a first lead line portion and a first winding portion that are in the opening peripheral region and connected to each other; the first winding portion partially surrounds the opening; the second signal line provides a second display signal to the pixel array, passes through the peripheral region of the opening along a second direction intersecting with the first direction, includes a second winding portion in the peripheral region of the opening and partially surrounds the opening. The first lead line portion and the second signal line have a first overlapping region, and the first winding portion and the second winding portion have a second overlapping region.

Abstract: Provided are a pharmaceutical composition of a compound of formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical formulation thereof; and a preparation method for the pharmaceutical composition and the pharmaceutical formulation, and use of the pharmaceutical composition and the pharmaceutical formulation in the preparation of a medicament for treating an AAK1-induced related disease by inhibition or degradation of AAK1.

Abstract: Embodiments of the present disclosure provide a display panel. The display panel includes a base substrate, wherein the base substrate includes an opening region and a display region, the display region surrounding the opening region. The plurality of isolation pillars are disposed on a first surface of the base substrate, and the plurality of isolation pillars are circular and surround the opening region. The isolation pillars include a first pillar made of an insulating material, and an isolation groove surrounding the opening region is disposed at both sides of the first pillar.

Abstract: A general formula for lysins based on which the activity and functionality are further screened and 24 lysins are identified and further investigated, nine of which are characterized. These lysins exhibit potent bactericidal activity, capable of lysing multiple species of Staphylococcus, Streptococcus, and/or Enterococcus; demonstrate robust environmental resistance and stability, retaining activity under varying temperatures, NaCl concentrations, pH levels, and in immune serum; and effectively treat localized and systemic infections. These lysins and their variants are promising as antimicrobial agents for eradicating bacteria, preventing bacterial infections, or treating bacterial infections (caused by genera Staphylococcus, Streptococcus, and/or Enterococcus).

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: Provided are a display panel and a display device. The display panel includes: a via hole penetrating through the display panel; a cutting residual area on the periphery of the via hole and includes a base substrate, and a packaging layer: and at least one annular relief structure between the packaging laver and the base substrate in the cutting residual area. The at least one annular relief structure is sequentially distributed around the via hole. At least one relief structure is provided with a surface facing away from the base substrate, and a side face connected to the surface, at least one of the surface and the side face is of a relief shape. The first relief structure is the relief structure with a smallest distance from the center of the via hole.

Abstract: The present invention discloses a bladder cancer detection kit and detection method. The kit includes a DHFR PCR reaction solution, a Twist1 and TSC21 PCR reaction solution, a point mutation positive control, a methylation positive control and a negative control. According to the present invention, by detecting the point mutation of a DHFR gene and the methylation level of a promoter region of TSC21 and Twist1 genes in a sample, the joint detection of gene point mutation and methylation is achieved for determining whether the sample is cancerous. The kit is convenient and simple to operate, high in detection sensitivity and high in specificity, and has a very positive significance in the detection of bladder cancer.

Abstract: Embodiments described herein generally relate to semiconductor device fabrication. More specifically, embodiments of the present disclosure relate to methods of forming a conformal liner on inner sidewalls of a via and/or a trench structure. The present disclosure generally provides a method of depositing a liner layer in a semiconductor structure. The method includes forming a passivation layer, forming a barrier layer, forming the liner layer, and filing the via and the trench with a conductive material. Forming the liner layer includes holding a precursor gas in a gas line upstream from a processing chamber behind a closed programmable logic control (PLC) valve, wherein the precursor gas is held behind the closed PLC valve for a PLC valve close period and releasing the precursor gas into the processing chamber by opening the PLC valve, wherein the precursor gas is released into the processing chamber for a PLC valve open period.

Abstract: The present invention provides liver cancer-associated serum microRNA markers and a new method for diagnosing liver cancer, wherein the liver cancer-associated serum microRNA markers consist of hsa-miR-122, hsa-miR-21, hsa-miR-2115, hsa-miR-221, hsa-miR-27 and hsa-miR-4499; relative expression level of the liver cancer-associated serum microRNA markers in serum is tested using Real-time PCR method, and reagents for the testing contains primers of the liver cancer-associated serum microRNA markers. The present invention can be used to diagnose hepatocellular carcinoma, in particular early hepatocellular carcinoma or to distinguish the serum of at least one patient with hepatocellular carcinoma from the serum of at least one healthy individual, the serum of at least one patient with chronic hepatitis B or the serum of at least one patient with liver cirrhosis.

Abstract: The present technology relates to systems and methods that allocate, arrange, and distribute certain types of functions and intelligence for autonomous driving systems (ADS) to facilitate vehicle operations and controls; to improve the safety of an autonomous vehicle (AV); and to ensure the efficiency, intelligence, reliability, and resilience of ADS. The present technology also provides methods to define ADS system intelligence and its levels, which are based on two dimensions: the vehicle intelligence and the cloud intelligence. The cloud intelligence supports and complements the vehicle intelligence when a vehicle is impaired or handicapped for certain functions (sensing, prediction, decision, and/or control) during operations in abnormal conditions. Distribution of driving intelligence between the AV and the cloud facilitates safe operations of the AV for long-tail corner cases.