Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: A battery core connecting assembly and a battery are provided in this disclosure. The battery core connecting assembly is configured for connecting a core of a lithium-ion battery. The lithium-ion battery includes a top cover, and the battery core connecting assembly includes an adapting piece and a connecting piece which at least in part includes a single-layer structure. The adapting piece includes a first tongue and a second tongue which are connected with each other, the first tongue is configured to be welded with the core, the adapting piece is pliable at a pliable part of the first tongue and the second tongue, and the adapting piece has a multi-layer structure at least at the pliable part. The connecting piece is connected with the second tongue of the adapting piece, and the connecting piece is welded with the top cover at a position of the single-layer structure.

Abstract: A metadata volume bitmap data conflict processing method. When the space allocation of a metadata volume encounters conflicts of 0-to-1 and 1-to-0, a conflict bit is set to be 1, so that when a garbage collector periodically performs space collection processing, data loss when data is overwritten due to collection of the bit to space corresponding to the bit in the case that I bit is detected to be 0 at one end may be avoided; when a conflict happens, conflict bits are both set to be 1, so that the conflict bits may be prevented from being allocated again, the space is prevented from being repeatedly allocated and repeatedly written and thus the data loss due to data overwriting is avoided, and after the garbage collection collects the conflict bits, continuous allocation may be performed, thereby implementing the repeated utilization of the conflict bits.

Abstract: A method for searching for free blocks in bitmap data. For searching for free blocks in the bitmap data, distribution information of free blocks can be directly obtained by performing array value solving operation, with the value of the integer data obtained by dividing the bitmap data into blocks being used as an index, on a template array. Also provided are an apparatus for searching for free blocks in the bitmap data, a device, and a readable storage medium.

Abstract: A method for searching free blocks in bitmap data. For free block search of one piece of bitmap data, by taking values of integer data obtained after bitmap data partitioning taken as subscripts, free block distribution condition information can be directly obtained by performing array value operation on a template array, so that great power consumption occupied by comparing and counting bits in the bitmap data one by one is avoided, and processing efficiency is greatly improved. Also provided are an apparatus for searching the free blocks in the bitmap data, a device, and a readable storage medium, which have the aforementioned beneficial effects.

Abstract: A metadata volume bitmap data conflict processing method. When the space allocation of a metadata volume encounters conflicts of 0-to-1 and 1-to-0, a conflict bit is set to be 1, so that when a garbage collector periodically performs space collection processing, data loss when data is overwritten due to collection of the bit to space corresponding to the bit in the case that I bit is detected to be 0 at one end may be avoided; when a conflict happens, conflict bits are both set to be 1, so that the conflict bits may be prevented from being allocated again, the space is prevented from being repeatedly allocated and repeatedly written and thus the data loss due to data overwriting is avoided, and after the garbage collection collects the conflict bits, continuous allocation may be performed, thereby implementing the repeated utilization of the conflict bits.

Abstract: A charging and discharging assembly, a battery core and a battery module are provided in the disclosure, which are applied in a lithium ion battery. The charging and discharging unit includes a positive electrode plate including positive tabs, a negative electrode plate including negative tabs, and a separator for separating the positive electrode plate and the negative electrode plate. The positive tab at least includes a first positive tab and a second positive tab, and the negative tab at least includes a first negative tab and a second negative tab. The positive electrode plate, the separator and the negative electrode plate are stacked with each other. The positive tabs and the negative tabs are respectively shifted to same sides of the positive electrode plate and the negative electrode plate.

Abstract: The present application discloses a Bacillus sp. producing a bioflocculant and a biosurfactant. The microbial classification of the Bacillus sp. is named Bacillus sp. SS15, which has been preserved in China Center for Type Culture Collection on Mar. 29, 2021, and its preservation number is CCTCC M2021295; the 16S rRNA sequence of SS15 is shown as SEQ ID NO.1. Bacillus sp. SS15 obtained by the present application has the function of simultaneously producing a bioflocculant and a biosurfactant. The bioflocculant and biosurfactant produced by Bacillus sp. SS15 of the present application not only have high activity, but also show strong tolerance in the ranges of pH (2-12), temperature (4° C.-100° C.) and salinity (0-100 g/L). Meanwhile, they can be applied to the remediation of a fracturing flowback liquid and can effectively promote the removal of chroma, suspended solids, COD, n-alkanes and polycyclic aromatic hydrocarbons at the same time.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: A method of suppressing wind noise of a microphone and/or an electronic device are disclosed. The method of suppressing wind noise of a microphone includes receiving an audio signal, obtaining a frequency spectrum of the audio signal and a power spectrum of the audio signal, determining a wind noise power spectrum of the audio signal based on the power spectrum, determining a wind noise suppression gain based on the wind noise power spectrum and the power spectrum, correcting the frequency spectrum according to the determined wind noise suppression gain, and converting the corrected frequency spectrum into a time domain to obtain a corrected audio signal.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: A fast phase frequency includes two fast pulsed-latches, a NAND gate, and an adjustable delay circuit, where the fast pulsed-latches include a pulse generating circuit, a reset circuit, and an output latch circuit. The pulse generating circuit is configured to generate a power supply pulse signal when a rising edge of the clock signal arrives, the power supply pulse signal causing the input of the output latch circuit to be a low level. The output latch circuit is configured to maintain its current output state when the clock signal or the reset signal is invalid, and the reset circuit is configured to set the input of the output latch circuit to be a high level. By using fast pulsed-latches with clock and reset control, the fast phase frequency detector shortens the reset loop delay and increases the maximum operating frequency of the phase frequency detector.

Abstract: A time-to-digital converter and a phase difference detection method are disclosed. The time-to-digital converter includes a detection unit and a digital control circuit. The detection unit comprising: a phase detection circuit, a first and a second clock signal are respectively coupled to an identical input terminal of the phase detection circuit and a reference signal is coupled to another input terminal of the phase detection circuit; the phase detection circuit is configured to output a pulse width corresponding to a phase difference between the first or the second clock signal and the reference signal; a filter circuit, coupled to an output terminal of the phase detection circuit; a ring oscillator circuit, coupled to an output terminal of the filter circuit and configured to output an oscillation clock signal corresponding to the pulse width. The digital control circuit is configured to provide the reference signal and receive the oscillation clock signal.

Abstract: A time-to-digital converter and a phase difference detection method are disclosed. The time-to-digital converter includes a detection unit and a digital control circuit. The detection unit comprising: a phase detection circuit, a first and a second clock signal are respectively coupled to an identical input terminal of the phase detection circuit and a reference signal is coupled to another input terminal of the phase detection circuit; the phase detection circuit is configured to output a pulse width corresponding to a phase difference between the first or the second clock signal and the reference signal; a filter circuit, coupled to an output terminal of the phase detection circuit; a ring oscillator circuit, coupled to an output terminal of the filter circuit and configured to output an oscillation clock signal corresponding to the pulse width. The digital control circuit is configured to provide the reference signal and receive the oscillation clock signal.

Abstract: Disclosed a fast phase frequency detector, comprising: two fast pulsed-latches, a NAND gate and an adjustable delay circuit. The fast pulsed-latches comprises: a pulse generating circuit, a reset circuit, and an output latch circuit; the pulse generating circuit is configured to generate a power supply pulse signal when a rising edge of the clock signal arrives, the power supply pulse signal causing the input of the output latch circuit to be a low level; the output latch circuit is configured to maintain its current output state when the clock signal or the reset signal is invalid; the reset circuit is configured to set the input of the output latch circuit to be a high level. By using fast pulsed-latches with clock and reset control, the fast phase frequency detector of the present application shortens the reset loop delay and increases the maximum operating frequency of the phase frequency detector.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.