Abstract: A fast phase frequency includes two fast pulsed-latches, a NAND gate, and an adjustable delay circuit, where the fast pulsed-latches include a pulse generating circuit, a reset circuit, and an output latch circuit. The pulse generating circuit is configured to generate a power supply pulse signal when a rising edge of the clock signal arrives, the power supply pulse signal causing the input of the output latch circuit to be a low level. The output latch circuit is configured to maintain its current output state when the clock signal or the reset signal is invalid, and the reset circuit is configured to set the input of the output latch circuit to be a high level. By using fast pulsed-latches with clock and reset control, the fast phase frequency detector shortens the reset loop delay and increases the maximum operating frequency of the phase frequency detector.

Abstract: A time-to-digital converter and a phase difference detection method are disclosed. The time-to-digital converter includes a detection unit and a digital control circuit. The detection unit comprising: a phase detection circuit, a first and a second clock signal are respectively coupled to an identical input terminal of the phase detection circuit and a reference signal is coupled to another input terminal of the phase detection circuit; the phase detection circuit is configured to output a pulse width corresponding to a phase difference between the first or the second clock signal and the reference signal; a filter circuit, coupled to an output terminal of the phase detection circuit; a ring oscillator circuit, coupled to an output terminal of the filter circuit and configured to output an oscillation clock signal corresponding to the pulse width. The digital control circuit is configured to provide the reference signal and receive the oscillation clock signal.

Abstract: A time-to-digital converter and a phase difference detection method are disclosed. The time-to-digital converter includes a detection unit and a digital control circuit. The detection unit comprising: a phase detection circuit, a first and a second clock signal are respectively coupled to an identical input terminal of the phase detection circuit and a reference signal is coupled to another input terminal of the phase detection circuit; the phase detection circuit is configured to output a pulse width corresponding to a phase difference between the first or the second clock signal and the reference signal; a filter circuit, coupled to an output terminal of the phase detection circuit; a ring oscillator circuit, coupled to an output terminal of the filter circuit and configured to output an oscillation clock signal corresponding to the pulse width. The digital control circuit is configured to provide the reference signal and receive the oscillation clock signal.

Abstract: Disclosed a fast phase frequency detector, comprising: two fast pulsed-latches, a NAND gate and an adjustable delay circuit. The fast pulsed-latches comprises: a pulse generating circuit, a reset circuit, and an output latch circuit; the pulse generating circuit is configured to generate a power supply pulse signal when a rising edge of the clock signal arrives, the power supply pulse signal causing the input of the output latch circuit to be a low level; the output latch circuit is configured to maintain its current output state when the clock signal or the reset signal is invalid; the reset circuit is configured to set the input of the output latch circuit to be a high level. By using fast pulsed-latches with clock and reset control, the fast phase frequency detector of the present application shortens the reset loop delay and increases the maximum operating frequency of the phase frequency detector.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: New 2-deoxy-2,3-dehydro-sialic acids and 2,7-anhydro-sialic acids, which are useful as sialidase inhibitors, and enzymatic methods for preparing them are disclosed. The methods include forming a reaction mixture comprising a glycoside acceptor, a sialic acid donor, and a sialyltransferase; maintaining the reaction mixture under conditions sufficient to form a sialoside; and contacting the sialoside with a Streptococcus pneumoniae sialidase to form the sialic acid product. Methods for the inhibition and sialidases and the treatment of cancer and infectious diseases are also disclosed.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selection antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

Abstract: The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selection antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract: An online application system and a method for implementing an online application system are disclosed. A method for implementing the online application system includes a) receiving a user search request from a user browser; b) searching for a match according to the search request and obtaining an online application that matches with the search request to form a search result page; and c) presenting the online application before the user browser in a form as a canvas page which is embedded in the search result page and is directly accessible from the search result page. The present disclosure also provides an online application system. The technical solutions disclosed herein allow a user to directly search out an online application via a search engine without a need to click multi-level linkages, thereby providing a quick and convenient search process which enhances the users' experiences with networks.

Abstract: An online application system and a method for implementing an online application system are disclosed. A method for implementing the online application system includes a) receiving a user search request from a user browser; b) searching for a match according to the search request and obtaining an online application that matches with the search request to form a search result page; and c) presenting the online application before the user browser in a form as a canvas page which is embedded in the search result page and is directly accessible from the search result page. The present disclosure also provides an online application system. The technical solutions disclosed herein allow a user to directly search out an online application via a search engine without a need to click multi-level linkages, thereby providing a quick and convenient search process which enhances the users' experiences with networks.

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.