Abstract: The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.

Abstract: The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.

Abstract: Electronic messages are displayed as tiles. A tile may include a background related to the electronic message. For example, the background of a tile may be a preview of an attachment to the message. When the message includes an attachment (e.g. document, picture, link . . . ), an overlay is displayed over the background. The overlay includes information relating to the electronic message (i.e. subject, sender, time, message preview . . . ). When the message does not include an attachment then the tile may include all/portion of the content of the electronic message. For example, the tile may include the subject, sender, time stamp, and message content. A user may switch between different browsing experiences (e.g. conversation view, list view, strip view, . . . ). When a tile represents a conversation each sender within the conversation may be displayed on a tile along with a preview of the messages of the conversation (i.e. the most recent message).

Abstract: Electronic messages are displayed as tiles. A tile may include a background related to the electronic message. For example, the background of a tile may be a preview of an attachment to the message. When the message includes an attachment (e.g. document, picture, link . . . ), an overlay is displayed over the background. The overlay includes information relating to the electronic message (i.e. subject, sender, time, message preview . . . ). When the message does not include an attachment then the tile may include all/portion of the content of the electronic message. For example, the tile may include the subject, sender, time stamp, and message content. A user may switch between different browsing experiences (e.g. conversation view, list view, strip view, . . . ). When a tile represents a conversation each sender within the conversation may be displayed on a tile along with a preview of the messages of the conversation (i.e. the most recent message).

Abstract: The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.

Abstract: The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.

Abstract: A first set of changes to a first version of a digital document, as compared to a baseline version of the document, can be detected. The first set of changes can include a first change to a page of the document in the first version of the document, as compared to the baseline version of the document. Also, a second set of changes to a second version of a document, as compared to the baseline version of the document, can be detected. The second set of changes can include a second change to the page of the document in the second version of the document, as compared to the baseline version of the document. A conflict between the first change and the second change can be detected, and the conflict can be resolved by receiving user input or applying conflict resolution rule(s) to choose between the first and second changes.

Abstract: The present invention relate to a method, an apparatus, and a terminal for wireless network connection. The method includes: acquiring lowest transmit power of a communication terminal that establishes connection with a wireless network access point, where the lowest transmit power is minimum transmit power that can ensure connection and communication between the communication terminal and the wireless network access point; and adjusting and determining transmit power of the communication terminal according to the lowest transmit power. With the implementation of the embodiments of the present invention, the communication terminal automatically reduces transmit power without affecting normal network connection, so that manual setting by users is avoided, electrical energy is saved, radiation is reduced, and convenient network access by users is ensured.

Abstract: A collaboration icon system displays collaboration icons representing a current collaboration state of a resource. The collaboration icon system determines the collaboration state of the resource. When the collaboration state indicates that the resource does not have multiple editors, the collaboration icon system displays a share icon that is selectable to support sharing the resource. When the collaboration state indicates that the resource has multiple editors, the collaboration icon system displays an editors icon to support sharing the resource and accessing information relating to the editors. The share icon and the editors icon provide an indication of the collaboration state while the resource is being accessed.

Abstract: Recommendations, such as recipients and attachments, are determined from content that is associated with a message item. A user may enter one or more: recipients; attachments; and message content for the message that may be used in determining recommendations. Keywords may also be identified by analyzing the content of the message to determine recommended content/recipients. Behavior patterns may also be used to determine recommendations. The recommended users/content of a message may be obtained from a messaging program, a local data store, a network data store, a cloud service, and the like. The recommended items (e.g. users/content) determined from analyzing the content are displayed such that they may be used by the user when editing the message item. The recommended items may be ranked by relevancy using metrics such as keywords, people, time last viewed and use patterns.

Abstract: Electronic messages are displayed as tiles. A tile may include a background related to the electronic message. For example, the background of a tile may be a preview of an attachment to the message. When the message includes an attachment (e.g. document, picture, link . . . ), an overlay is displayed over the background. The overlay includes information relating to the electronic message (i.e. subject, sender, time, message preview . . . ). When the message does not include an attachment then the tile may include all/portion of the content of the electronic message. For example, the tile may include the subject, sender, time stamp, and message content. A user may switch between different browsing experiences (e.g. conversation view, list view, strip view, . . . ). When a tile represents a conversation each sender within the conversation may be displayed on a tile along with a preview of the messages of the conversation (i.e. the most recent message).

Abstract: The chiral compound S-5-substituted-N-2?-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5).

Abstract: The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The anti-viral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.

Abstract: The chiral compound S-5-substituted-N-2?-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2?-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5).

Abstract: Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl-5-(4-methyl-1H-imidazole-1-yl)-benzeneamine; 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino) -4-methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib.3HCl and its crystalline forms are also described.

Abstract: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.

Abstract: The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and salts thereof are obtained.