Patents by Inventor Yanning Rui

Yanning Rui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AUTOPHAGY AS A THERAPEUTIC TARGET FOR INTRACRANIAL ANEURYSM
    Publication number: 20230270715
    Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.
    Type: Application
    Filed: May 25, 2022
    Publication date: August 31, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Yanning Rui, Zhen Xu, John Hagan
  • PODOSOMES AS A THERAPEUTIC TARGET FOR INTRACRANIAL ANEURYSM
    Publication number: 20230210858
    Abstract: Disclosed here are uses of anti-podosome therapies for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that endothelial podosomes plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 6, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Zhen Xu, Yanning Rui, John Hagan
  • METHODS AND REAGENTS FOR CHARACTERIZING THSD1 FUNCTION
    Publication number: 20230212522
    Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 6, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Yuanqing Yan, Yanning Rui, Zhen Xu, John Hagan
  • TGF-B AS A THERAPEUTIC TARGET FOR INTRACRANIAL ANEURYSM
    Publication number: 20230212246
    Abstract: Disclosed here are metal coils conjugated to TGF-beta ligand(s) or TGF-beta activator(s) to improve the outcome of existing surgical treatments on intracranial aneurysm patients and methods for using the same.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 6, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Zhen Xu, Yanning Rui, John Hagan