Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.

Abstract: A cell management method, a trigger condition configuration method, a terminal device, and a network-side device are provided. The method includes: receiving configuration information of a trigger condition and configuration information of a trigger event that are sent by a network-side device, where an association relationship exists between the configuration information of the trigger condition and the configuration information of the trigger event, and configuration information of one trigger condition is associated with configuration information of at least two trigger events; determining, based on the configuration information of the at least two trigger events associated with the configuration information of the trigger condition, whether the trigger condition is satisfied; and when the trigger condition is satisfied, initiating a radio resource control RRC procedure for cell management.

Abstract: This application discloses a time information sending method, a terminal, and a network-side device, and pertains to the communication field. The method includes: in a case that a first condition is satisfied, sending first time information to a network side, where the first time information is used for obtaining a timing advance value of the terminal.

Abstract: A cell management method, a trigger condition configuration method, a terminal device, and a network-side device are provided. The method includes: receiving configuration information of a trigger condition and configuration information of a trigger event that are sent by a network-side device, where an association relationship exists between the configuration information of the trigger condition and the configuration information of the trigger event, and configuration information of one trigger condition is associated with configuration information of at least two trigger events; determining, based on the configuration information of the at least two trigger events associated with the configuration information of the trigger condition, whether the trigger condition is satisfied; and when the trigger condition is satisfied, initiating a radio resource control RRC procedure for cell management.

Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.

Abstract: Embodiments of this disclosure provide a serving node update method and a device. The method includes: sending a first message to a target node; receiving, from the target node, a second message used for responding to the first message; and sending a third message to a terminal device when the second message indicates that the target node rejects a multi-connectivity serving node update, where the third message is used to indicate the terminal device to perform a serving node update in a legacy serving node update manner.

Abstract: The embodiments of this application disclose a method for generating sign language video performed by a computer device. The method includes the following steps: acquiring acquiring listener text, the listener text conforming to grammatical structures of a hearing-friendly person; performing summarization extraction on the listener text to obtain summary text, a text length of the summary text being shorter than a text length of the listener text; converting the summary text into sign language text, the sign language text conforming to grammatical structures of a hearing-impaired person; and generating the sign language video based on the sign language text.

Abstract: A flexible variable frequency ultrasonic therapeutic probe based on thermoacoustic effect of a carbon nanotube film comprises an ultrasonic sound production element, and a heat dissipation layer and an acoustic matching layer located on both sides thereof. The sound production element comprises a carbon nanotube film, metal electrodes and wires, and the shape and size of the sound production element can be adjusted according to the actual functional requirements. When a signal is accessed into the sound production element, the carbon nanotube film produces a corresponding temperature change, which causes the surrounding media to expand and contract and to excite ultrasonic waves. The present invention greatly improves the coupling efficiency between the probe and the subject, reduces the energy loss of ultrasonic waves, and enhances the uniformity of the sound intensity distribution in the affected part.

Abstract: A service node updating method is provided. The method is performed by a terminal device and includes: receiving configuration information, where the configuration information includes first connectivity configuration information used to maintain both a connection to a source node and a connection to a target node in a service node updating procedure and second connectivity configuration information used to release the connection to the source node and connect to the target node; processing, by applying the first connectivity configuration information, a layer 2 protocol entity corresponding to a bearer between the terminal device and the source node, to reconfigure the bearer as a source node split bearer; and processing, by applying the second connectivity configuration information, a layer 2 protocol entity corresponding to the bearer, to reconfigure the source node split bearer as a target node bearer.

Abstract: Embodiments of this application disclose a resource allocation method and apparatus and a terminal, where the method includes: obtaining a first uplink grant for new transmission by a terminal; and performing resource allocation for a resource designated by the first uplink grant, according to at least one of the following: HARQ uplink retransmission indication, configuration of enabling or disabling of HARQ uplink retransmission for a HARQ process, configuration of enabling or disabling of HARQ uplink retransmission for a logical channel, and association between logical channels and HARQ processes.

Abstract: Disclosed is a method for enhancing thermal energy storage performance of industrial grade hydrated salts based on phase change, comprising: heating an aqueous system of industrial grade hydrated salts containing 105-130 percent (%) by mass of m0 industrial grade hydrated salt to m0, taking a sample for differential scanning calorimeter testing and recording its melting enthalpy as ?H1; melting and adding water into, or melting and evaporating the residual aqueous system of industrial grade hydrated salts or the residual industrial grade hydrated salts system with a mass of m1 to increase or decrease the mass by 0.4-0.8% m0 until a melting enthalpy ?Hn of a sample that taken from the residual aqueous system of industrial grade hydrated salts with a mass of mn satisfies ?H2< . . . <?Hn>?Hn+1.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

Abstract: A paging message receiving method, a paging configuration method, a terminal, and a network side device, are provided. The paging message receiving method includes: in a case that the terminal meets a preset condition, monitoring a paging resource at a paging occasion, where the paging resource is used to carry paging indication information, and the preset condition includes: the terminal is in an air interface connected state; and determining that there is a paging message according to the paging indication information, and receiving the paging message.

Abstract: A steel ladle drainage method, is achieved by using a steel ladle structure. Vacuum interlayers are provided within an upper nozzle, an upper fixed plate, alower fixed plate and a sliding plate of the steel ladle structure respectively. In the steel ladle drainage method provided by the present invention, a metal drainage agent is used to replace the drainage sand in the prior art, the metal drainage agent is melted by the liquid steel and deposited in the upper nozzle, the sliding plate with the vacuum interlayer and the upper nozzle with the vacuum interlayer have the insulation effect on the melted metal drainage agent, agent falling. Moreover, through moving the sliding plate, the two pouring holes of the upper and lower fixed plates are connectedwith each other, the metal drainage agent enters the tundish through the pouring holes and the lower nozzle under the action of gravity.

Abstract: A cell management method, a trigger condition configuration method, a terminal device, and a network-side device are provided. The method includes: receiving configuration information of a trigger condition and configuration information of a trigger event that are sent by a network-side device, where an association relationship exists between the configuration information of the trigger condition and the configuration information of the trigger event, and configuration information of one trigger condition is associated with configuration information of at least two trigger events; determining, based on the configuration information of the at least two trigger events associated with the configuration information of the trigger condition, whether the trigger condition is satisfied; and when the trigger condition is satisfied, initiating a radio resource control RRC procedure for cell management.

Abstract: A method of transmitting configuration information and a related device are provided. The method includes sending DC assistance information to a network-side device, wherein the network-side device includes at least one of an MN and an SN; receiving assistance configuration information of DC interference cancellation sent by the network-side device, wherein the assistance configuration information of DC interference cancellation corresponds to the IDC assistance information.

Abstract: A compound of formula (I) or a tautomer, a stereoisomer, a solvate, a nitrogen oxide, a prodrug, an isotope derivative or a pharmaceutically acceptable salt thereof exhibit kinase inhibitory activity against a variety of kinases (such as TRK, ALK and ROS1) and mutants thereof, in particular TRK and a mutant form thereof. An in vitro cell inhibitory activity test and an in vivo anti-tumor model test show that the compounds have a strong inhibitory effect on a variety of cells containing TRK mutations and tumors, have a good safety, and have a good clinical value as drugs.

Abstract: Provided is a modified Fc region. The Fc region has at least one amino acid mutation with respect to a parent Fc region. The modified Fc region has improved affinity to Fc?RIIB with respect to the affinity of the parent Fc region to Fc?RIIB Also provided is an antibody containing the modified Fc region, especially an agonistic antibody. The modified Fc region has significant use for optimizing the agonistic activity of the antibody.

Abstract: A service node updating method is provided. The method is performed by a terminal device and includes: receiving configuration information, where the configuration information includes first connectivity configuration information used to maintain both a connection to a source node and a connection to a target node in a service node updating procedure and second connectivity configuration information used to release the connection to the source node and connect to the target node; processing, by applying the first connectivity configuration information, a layer 2 protocol entity corresponding to a bearer between the terminal device and the source node, to reconfigure the bearer as a source node split bearer; and processing, by applying the second connectivity configuration information, a layer 2 protocol entity corresponding to the bearer, to reconfigure the source node split bearer as a target node bearer.

Abstract: A computer-implemented method, comprising receiving an order associated with a user, and capturing information associated with a physical attribute of the user; for the order being completed, performing a matching operation on the physical attribute of the user and information associated with a region of the user that includes the physical attribute of the user and respective physical attributes of other users, to determine a closest match; and generating an output that identifies the user associated with the closest match in the information associated with the region of the user, and providing the output to a server to deliver the order to the user.