Abstract: An object of the present invention is to provide a compound useful as an anti-tumor agent or the like; an intermediate thereof; and a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound.

Abstract: An object of the present invention is to provide a compound useful as an anti-tumor agent or the like, as well as a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, a compound represented by General Formula (1) or a salt thereof is provided. In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; R2, R3, R4, and R5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted, a C1-6 alkoxy group which may be substituted, or the like; R6's are the same as or different from each other and each represent a halogen atom, a C1-6 alkyl group which may be substituted, or a C1-6 alkoxy group which may be substituted; R7 represents a C3-8 cycloalkyl group which may be substituted, or the like; m represents an integer of 0 to 6; and a broken line represents a single bond or a double bond.

Abstract: Provided is an expansible catheter balloon that has a spreadable outer diameter controllable easily in treatments for a calcific aortic stenosis, rheumatic and congenital aortic stenoses and others, and that can be effectively prevented from being freely shifted and can easily be fixed at a predetermined position. The catheter balloon includes a balloon having shoulder parts made of a non-expansible material or made low-expansible and an expandable waist part, and a catheter having a catheter body to which this balloon is fitted.

Abstract: Provided is an expansive catheter balloon that has a spreadable outer diameter controllable easily in treatments for a calcific aortic stenosis, rheumatic and congenital aortic stenosis and others, and that can be effectively prevented from being freely shifted and can easily be fixed at a predetermined position. The catheter balloon includes a cylindrical balloon part that is made non-expansive or low-expansive, and a band part made of a stretchable elastic body. When a stretching force is not applied, the band part has a shorter diameter than a spread diameter of the balloon part and is wound around the center of the balloon part.

Abstract: An amidine compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Abstract: The external surface of a balloon for IABP balloon catheter is designed to have a rough surface occupying an area of 10 to 80% both inclusive of the whole of the external surface, and a smooth surface occupying an area of 90 to 20% both inclusive thereof. The supplied balloon for IABP balloon catheter is certainly unwrapped by a predetermined balloon pressure from a driving machine, with no need to conduct any preloading process, and further which is not unwrapped before and during the insertion of the catheter even in the state that a wrapping sheath is removed.

Abstract: A filter device for capturing embolic material capable of retrogradely installing a filter is provided. A filter device for capturing embolic material has a core wire moving a filter member to a target position in a blood vessel, a guide portion formed on the distal front end side of the core wire and guiding the core wire in the blood vessel, the filter member provided on the core wire and capturing a blood clot and debris, and a sheath capable of extending the core wire therethrough.

Abstract: The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent.

Abstract: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Abstract: Disclosed is a compound represented by the general formula: wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom, or a salt thereof, which is useful as an antibacterial agent.

Abstract: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Abstract: Disclosed is a compound represented by the general formula: wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom, or a salt thereof, which is useful as an antibacterial agent.

Abstract: A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Abstract: Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

Abstract: A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R1, R2, R3, R4 and R5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X1 represents a lower alkylene group or the like; X2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof.

Abstract: A steering gearbox mounting structure having an intermediate bracket mounts a steering gearbox for steering wheels of a vehicle on a subframe of the vehicle. The intermediate bracket has a breakable portion which breaks when a force greater than a predetermined force is applied to the breakable portion to provide an impact absorbing stroke of an engine of the vehicle. The breakable portion may have a thin portion such as a plate or a recess portion and is more breakable in the traveling direction than the width direction. First and second intermediate brackets may be used which include first and second kinds of breakable portions that are breakable in different modes, respectively.

Abstract: A balloon catheter comprises a long shaft including an inner pipe and an outer pipe, and a balloon provided at a distal end of the shaft, a distal end of the balloon being connected to the inner pipe, a proximal end of the balloon being connected to the outer pipe, and the balloon being inflated and deflated according to pressure of fluid supplied to an inside of the balloon. The balloon is molded in advance such that the balloon is inflated by pressure only to an extent in which a film of the balloon is not stretched, such that the balloon becomes a curved shape having a curved part between the proximal end and the distal end of the balloon, and such that the balloon, when deflated, is folded so as to be in a straight shape, in which the curved part is hidden, and wound around the inner pipe.

Abstract: Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

Abstract: An engine control system includes an EGR device 10 which connects an exhaust passage Ex and an intake passage I and has an EGR valve; an intake throttle valve 41 placed in the intake passage I; and an engine control unit which is provided with an engine operation data calculator A1 accumulating mileages of a vehicle or an engine operation period, a fuel injection controller A2 controlling a fuel injection amount and a fuel injection timing, an EGR controller A3 controlling an opening of the EGR valve; a throttle valve controller A4 controlling an opening of the intake throttle valve; and an EGR passage cleaning controller A5 which delays a fuel injection timing Tn, increases an opening ? g of the EGR valve, and reduces an opening ? s of the intake throttle valve when the total mileage or the total operation period calculated by the engine operation data calculator becomes equal to a predetermined threshold.

Abstract: A forced regeneration device which performs regeneration of a particulate filter includes oxidation catalysts (23, 24a) disposed upstream from the particulate filter or in said particulate filter and a burner (30) located upstream from the oxidation catalysts and operable switching between a combustion mode for combusting a fuel spray by inflammation to raise temperature of exhaust gases in an exhaust passage and a fuel supply mode for supplying only a fuel spray to the exhaust passage without inflammation. After the burner operates in the combustion mode, the burner operation is switched to the fuel supply mode.