Patents by Inventor Yasuhisa Minagawa
Yasuhisa Minagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240420807Abstract: Provided are a highly accurate method for predicting a physical property of a polymer and a polymer having excellent physical properties such as an ability to selectively capture specific cells and biocompatibility.Type: ApplicationFiled: June 3, 2024Publication date: December 19, 2024Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventor: Yasuhisa Minagawa
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Publication number: 20240409768Abstract: Provided is a method of producing a polymer-coated substrate for capturing cancer cells in which a polymer layer is stably maintained on the surface of the substrate for a long time even in a liquid environment. The method of producing a polymer-coated substrate for capturing cancer cells includes forming a polymer layer using a hydrophilic polymer represented by the following formula (I) on a surface of a substrate having undergone anti-reflection treatment, wherein R1 represents a hydrogen atom or a methyl group; R2 represents an alkyl group; m represents 1 to 5; and n represents the number of repetitions.Type: ApplicationFiled: May 13, 2024Publication date: December 12, 2024Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Takahisa ANADA, Aki YAMAMOTO, Hironori SHINDO, Jisu PARK, Kazuma UJIGAWA
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Publication number: 20240343934Abstract: Provided is a polymer-coated glass substrate having a surface with controlled irregularity and a low elastic modulus. The polymer-coated glass substrate includes a glass substrate and two or more hydrophilic polymer layers on a surface of the glass substrate.Type: ApplicationFiled: March 18, 2024Publication date: October 17, 2024Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa MINAGAWA, Chiaki DOKAI
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Publication number: 20240217869Abstract: Provided is a polymer-coated glass substrate that can reduce the capture of normal cells such as blood cells and selectively capture specific cells such as cancer cells. The present disclosure relates to a polymer-coated glass substrate which includes a glass substrate and a polymer layer formed on a surface of the glass substrate, a surface of the polymer layer having an elastic modulus in water or an aqueous solution of 1.20 MPa or lower.Type: ApplicationFiled: November 27, 2023Publication date: July 4, 2024Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventor: Yasuhisa MINAGAWA
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Publication number: 20230357597Abstract: Provided are a polymer-coated substrate in which a polymer layer formed on the surface of a substrate is stable for a long period of time even in a liquid environment, and a medical analysis device including the polymer-coated substrate. Included is a polymer-coated substrate which includes a substrate, a silane compound layer formed on a surface of the substrate, and a polymer layer formed on the silane compound layer.Type: ApplicationFiled: March 2, 2023Publication date: November 9, 2023Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa MINAGAWA, Mitsuko TAKII
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Patent number: 11660596Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture specific cells such as many types of cancer cells including cancer cells not expressing EpCAM and stem cells. Provided is a medical analysis device including a well portion, the well portion having a hydrophilic silane compound layer formed at least partly on the inner surface thereof.Type: GrantFiled: March 25, 2020Date of Patent: May 30, 2023Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Haruka Emura, Kazuki Suto
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Patent number: 11614440Abstract: Provided are specific cell-fractionating and -capturing methods which can fractionate and capture, respectively, specific cells (e.g., many types of cancer cells, including cancer cells not expressing EpCAM, or peripheral blood stem cells). Included is a method for fractionating specific cells present in blood or biological fluid, the method including fractionating the blood or biological fluid by centrifugation to collect the specific cells in the blood or biological fluid, the centrifugation being carried out using a container having a low protein adsorbing layer at least partially formed on the inner surface thereof.Type: GrantFiled: December 27, 2019Date of Patent: March 28, 2023Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Haruka Emura, Kazuki Suto
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Patent number: 11573232Abstract: The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM), and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: agglutinating blood cells in sampled blood or biological fluid; centrifuging the resulting blood or biological fluid; and then capturing specific cells therefrom onto a hydrophilic polymer layer.Type: GrantFiled: January 16, 2019Date of Patent: February 7, 2023Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Haruka Emura
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Patent number: 11367868Abstract: An object of the present disclosure is to provide a new sulfur-based positive-electrode active material which can improve cyclability of a lithium-ion secondary battery while maintaining a charging and discharging capacity, a positive-electrode comprising the positive-electrode active material, and a lithium-ion secondary battery comprising the positive-electrode. The sulfur-based positive-electrode active material is one comprising doped nitrogen atoms obtainable by heat-treating a starting material comprising a chain organic compound and sulfur under an atmosphere of a nitrogen atom-doping gas.Type: GrantFiled: November 4, 2019Date of Patent: June 21, 2022Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Tatsuya Kubo, Fumiya Chujo, Yasuhisa Minagawa
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Patent number: 11360078Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.Type: GrantFiled: March 25, 2020Date of Patent: June 14, 2022Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 11226330Abstract: The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.Type: GrantFiled: January 16, 2019Date of Patent: January 18, 2022Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITY, OSAKA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Haruka Emura, Masaki Mori, Hirofumi Yamamoto, Naotsugu Haraguchi
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Publication number: 20210372895Abstract: Provided are hydrophilic substrates provided with a hydrophilic polymer layer having controlled surface uniformity and irregularities, and methods for preparing the hydrophilic substrates. Included are hydrophilic substrates including a substrate having a surface containing at least one group represented by —N(R1)2 or —N(R2)3+ wherein each R1 or R2 is the same or different and represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group optionally containing a hetero atom; and a hydrophilic polymer layer provided on the surface of the substrate.Type: ApplicationFiled: April 29, 2021Publication date: December 2, 2021Applicant: Sumitomo Rubber Industries, Ltd.Inventor: Yasuhisa MINAGAWA
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Patent number: 11152083Abstract: A simulation method for analyzing a breakage of a molecular chain of a polymer material using a computer comprises: defining a polymeric material model by setting a molecular chain model in a virtual space corresponding to a portion of the polymeric material; and calculating a breaking of the molecular chain model.Type: GrantFiled: August 21, 2017Date of Patent: October 19, 2021Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasumasa Bito, Yasuhisa Minagawa
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Patent number: 10975176Abstract: The present invention provides a hydrophilic substrate including a hydrophilic polymer layer having a smooth surface and formed of a special polymer (hydrophilic polymer). Included is a hydrophilic substrate including on its surface a hydrophilic polymer layer formed of a hydrophilic polymer having a number average molecular weight of 40,000 or more.Type: GrantFiled: January 2, 2019Date of Patent: April 13, 2021Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa Minagawa, Mitsuko Takii
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Publication number: 20210101829Abstract: Provided are a hydrophilic substrate provided with a highly smooth hydrophilic silane compound layer having less surface irregularities and a method of manufacturing the hydrophilic substrate. The present invention relates to a hydrophilic substrate including a substrate having a hydrophilized surface and a hydrophilic silane compound layer provided on at least part of the hydrophilized surface of the substrate.Type: ApplicationFiled: September 4, 2020Publication date: April 8, 2021Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa MINAGAWA, Mitsuko TAKII
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Patent number: 10954352Abstract: Provided are methods for surface-modifying a rubber vulcanizate and surface-modified elastic bodies, which can cost-effectively provide a variety of functions, including sliding properties, liquid leakage resistance, and protein adsorption resistance. Included is a method for surface-modifying a rubber vulcanizate as a modification target, the method including: step 1 of forming polymerization initiation points A on the surface of the modification target; step 2 of radically polymerizing a monomer starting from the polymerization initiation points A to grow polymer chains; and step 3 of adding a silane compound to the surfaces of the polymer chains, followed by reaction with at least a fluoroalkyl group-containing silane compound to form modified polymer chains.Type: GrantFiled: March 29, 2019Date of Patent: March 23, 2021Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventor: Yasuhisa Minagawa
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Patent number: 10941374Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.Type: GrantFiled: September 1, 2017Date of Patent: March 9, 2021Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya
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Patent number: 10835644Abstract: The present invention provides surface-modified metals such as metal medical devices, e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, in which a lubricant layer is firmly bonded to the surface to impart lubricity to the surface, and further to improve the durability of the lubricant layer on the surface, thereby reducing deterioration of sliding properties, as well as methods for modifying a metal surface. The present invention relates to a surface-modified metal having a surface at least partially treated by polymerizing a monomer in the presence of a hydrogen abstraction type photopolymerization initiator.Type: GrantFiled: October 8, 2014Date of Patent: November 17, 2020Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.Inventors: Yasuhisa Minagawa, Takefumi Nakashita
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Publication number: 20200338554Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture specific cells such as many types of cancer cells including cancer cells not expressing EpCAM and stem cells. Provided is a medical analysis device including a well portion, the well portion having a hydrophilic silane compound layer formed at least partly on the inner surface thereof.Type: ApplicationFiled: March 25, 2020Publication date: October 29, 2020Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa MINAGAWA, Masaru TANAKA, Haruka EMURA, Kazuki SUTO
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Patent number: 10786812Abstract: Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. The medical analysis device includes a flow channel zone, and also includes a chamber zone. The inner surface of the flow channel zone is at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.Type: GrantFiled: April 24, 2017Date of Patent: September 29, 2020Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., YAMAGATA UNIVERSITYInventors: Yasuhisa Minagawa, Masaru Tanaka, Takashi Hoshiba, Tomokazu Shibuya