Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket having at least two annular projections and at least one annular valley on its sliding surface, the sliding surface being at least partially provided with immobilized polymer chains, the annular projections including a first projection nearest to the top surface and any other projection, the outer diameters of the other projection and the annular valley being in the range of 94 to 98% and 85 to 92%, respectively, with respect to the outer diameter of the first projection taken as 100%.

Abstract: Methods are provided for surface-modifying a rubber vulcanizate or a thermoplastic resin. The methods allow these objects to have a chemically fixed surface layer that exhibits not only low adsorption or selective adsorption properties with respect to proteins and cells, but also excellent durability, instead of having a coating which has drawbacks such as reduction in properties due to separation or peeling of the coating. Included is a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic resin, the method including: a step 1 of forming polymerization initiation points on the surface of the object; and a step 2 of radically polymerizing a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm in the presence of an alkali metal salt to grow polymer chains on the surface of the object.

Abstract: Provided are methods for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, the methods forming a surface with a chemically fixed lubricant instead of resin coating which has drawbacks, such as that the coating is, for example, removed or peeled during the movement within a vessel, whereby the lubricity is reduced. The present invention relates to a method for surface-modifying an object of a rubber vulcanizate or a thermoplastic elastomer, the method including step 1 of forming polymerization initiation points on a surface of the object, and step 2 of radically polymerizing a deliquescent monomer starting from the polymerization initiation points by irradiation with ultraviolet light having a wavelength within the range of 300 to 400 nm, to grow polymer chains on the surface of the object.

Abstract: A method for defining bond potential of polymer material, which is the bond potential between at least two atoms constituting a molecular chain of the polymer material, by using a computer comprises steps S4 and S5. In the step S4, the computer obtains a potential curve indicating relationship between potential energy of the first molecular model in which the at least two particle models are associated with each other and a distance between the at least two particle models without making a structural relaxation calculation for the first molecular model by the computer. In the step S5, the computer defines the bond potential by using Morse-type function. The step S5 of defining the bond potential includes a calculation step for specifying fitting parameters Forcec and DLim of the Morse-type function such that the Morse-type function approximates the potential curve.

Abstract: Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.

Abstract: The present invention provides metal medical devices which are provided with sliding properties (lubricity), low protein adsorption properties and low cell adsorption properties and further in which these properties are prevented from deteriorating. The present invention relates to a metal medical device having a surface at least partially treated with a copolymer C of a polymerizable silane compound A and a polymerizable compound B that contains a functional group.

Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket whose sliding surface includes annular projections, the gasket having polymer chains immobilized on at least part of its surface, the annular projections including a first projection that is nearest to a top face, and a bottom side projection that is farthest from the top face, the first projection and/or the bottom side projection having an annular flat portion with a width of 0.1 mm or more.

Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket including a gasket base material whose surface is at least partially provided with immobilized polymer chains, the gasket having a sliding surface provided with multiple annular projections, the annular projections including a first projection nearest to the top surface of the gasket, the first projection having a surface roughness Ra of 1.0 or less.

Abstract: Provided are surface treatment agents that enable surfaces with a chemically fixed lubricant to be produced instead of a resin coating which has drawbacks, such as that lubricity is reduced due to separation, peeling or the like of the coating during the movement within a vessel or tube; and medical devices, such as catheters, having a surface at least partially treated with such a surface treatment agent. The present invention relates to a surface treatment agent for medical devices which contains a copolymer of a hydrophilic functional group-containing monomer and an epoxy group-containing monomer.

Abstract: The present invention provides a rubber composition for a tire, which has an increased rate of reaction between a silane coupling agent and silica so that its performances including fuel economy and abrasion resistance can be enhanced; and a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for a tire, containing: diene rubber; silica; a silane coupling agent; and a carbonate salt and/or a hydrogen carbonate salt, wherein the rubber composition has a total content of the carbonate salt and the hydrogen carbonate salt of 0.3 to 25 parts by mass relative to 100 parts by mass of the silica.

Abstract: Provided are surface-modified metals such as metal medical devices, e.g. guide wires, syringe needles, and metal tubes in medical devices or equipment, and methods for modifying a metal surface, wherein a lubricant layer is firmly bonded to the metal surface to impart lubricity to the metal surface and further to improve the durability of the lubricant layer on the metal surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified metal at least partially having a treated surface, the treated surface being obtained by treating a surface of a metal with a silane coupling agent, followed by adsorbing a hydrogen abstraction type photopolymerization initiator onto the surface and then polymerizing a monomer in the presence of an alkali metal salt.

Abstract: Provided are methods for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which can cost-effectively provide a variety of functions, e.g. sliding properties or liquid leakage resistance.

Abstract: Provided are methods for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which enable surfaces with a chemically fixed lubricant to be produced instead of a resin coating which has drawbacks, such as that lubricity is reduced due to separation, peeling or the like of the coating during the movement within a vessel or tract. The present invention relates to a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic elastomer, the method including step 1 of forming polymerization initiation points on a surface of the object, and step 2 of radically polymerizing a halogen-containing deliquescent monomer, starting from the polymerization initiation points, by irradiation with ultraviolet light having a wavelength within the range of 300 to 400 nm to grow polymer chains on the surface of the object.

Abstract: The present invention provides a method for capturing cancer cells which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a method for capturing cancer cells present in biological fluid, the method including reducing the protein level of sampled biological fluid, followed by capturing cancer cells using a hydrophilic polymer layer.

Abstract: The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.

Abstract: The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.

Abstract: A simulation method for analyzing a breakage of a molecular chain of a polymer material using a computer comprises: defining a polymeric material model by setting a molecular chain model in a virtual space corresponding to a portion of the polymeric material; and calculating a breaking of the molecular chain model.

Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket having at least two annular projections and at least one annular valley on its sliding surface, the sliding surface being at least partially provided with immobilized polymer chains, the annular projections including a first projection nearest to the top surface and any other projection, the outer diameters of the other projection and the annular valley being in the range of 94 to 98% and 85 to 92%, respectively, with respect to the outer diameter of the first projection taken as 100%.

Abstract: Provided are a sliding elastic body capable of imparting excellent sliding properties and resistance to protein adsorption and, at the same time, maintaining sealing properties; and a syringe gasket, a catheter, and a tire which include the sliding elastic body. The present invention relates to a sliding elastic body including an elastic body whose surface is fully or partially laminated with a fluororesin film, the laminated elastic body being treated with a fluorinated oil.

Abstract: Provided are methods for surface-modifying a thermoplastic resin which produce surfaces that show not only low adsorption of proteins and cells but also selective adsorption or adhesion of specific cells such as cancer cells, and further have excellent durability. A method for surface-modifying an object made of a thermoplastic resin, the method including: step 1 of forming polymerization initiation points on the surface of the object; and step 2 of radically polymerizing at least a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm to form a graft layer having a thickness of 2 to 100 nm on the surface of the object.