Abstract: A developing device for a toner powder cloud development system, which can achieve high image quality and can be made compact. The developing device has a two-component development unit, a toner carrier, and an alternating current power source. The toner carrier, which is arranged opposing a latent image carrier, has a plurality of electrodes disposed in a line in a prescribed direction on the surface thereof, and mutually insulated. The alternating current power source supplies a voltage such that an electric field across the plurality of electrodes is temporally switched. The inter-electrode electric field causes the toner being carried on the surface of the toner carrier to carry out hopping, thereby forming a toner powder cloud and carrying out development. The movement speed of the latent image carrier and the linear velocity of the toner carrier are set at approximately equivalent speeds.

Abstract: An apparatus for developing a latent image on a latent image carrier includes a toner carrier and multiple electrodes arranged at intervals on a surface of the toner carrier. A potential difference is formed between even-numbered electrodes and odd-numbered electrodes of the electrodes by applying a first pulse voltage to the even-numbered electrodes and a second pulse voltage to the odd-numbered electrodes so that toner on the surface of the toner carrier moves back and forth between the electrodes, where the first and second pulse voltages are in different phases, and the toner moving back and forth between the electrodes is conveyed to a position facing the latent image carrier by movement of the surface of the toner carrier and thereby caused to adhere to the latent image on the latent image carrier.

Abstract: An image forming apparatus includes a toner-layer filling-rate lowering unit that causes a toner layer of toner images to be formed on an image carrier so that the toner layer has sufficient optical transparency for exposing and the toner-layer filling rate is set relatively low; and a toner rolling rate adjusting unit that rolls the toner images at a predetermined toner rolling rate in accordance with the toner-layer filling rate when the toner images are transferred to the transferring/fixing unit.

Abstract: A development apparatus using a hopping method and an image formation apparatus including the development apparatus are disclosed. The development apparatus includes a toner supporting object for supporting and conveying a toner by a movement of the toner supporting object, while the toner is hopping on a surface of the toner supporting object by an electric field; a regulating member made of a flexible material for constituting a toner thickness regulation position; a latent image supporting object for supporting a latent image; and a development position, which is a position of the toner supporting object, that counters the latent image supporting object; wherein the toner is conveyed through the regulation position to the development position where the toner is adhered to the latent image, and wherein one end of the regulating member is supported, and the other end contacts the toner supporting object.

Abstract: The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue at position 35 with another amino acid in an amino acid sequence of SEQ ID NO:2; and (b) a polypeptide having an amino acid sequence having one or more substituted, deleted, inserted or added amino acids in positions except for positions 32 and 35, preferably positions 32 to 35 in the amino acid sequence of SEQ ID NO:2, and having an apoptosis-inducing activity.

Abstract: An developer bearer conveys developer to a developing station under influence of an electric field created by an electric flux line. The developer bearer includes plural kinds of electrodes that receive different voltages from each other and collectively creates the electric flux line. The plural kinds of electrodes are arranged on different layers in a normal line of the developer bearer. The developer bearer includes an insulation layer that insulates the plural kinds of electrodes.

Abstract: A disclosed development device includes: a latent image carrier; a conveying member disposed so as to face the latent image carrier, the conveying member having plural electrodes insulated from one another and arranged at predetermined intervals so as to generate an electric field for moving toner on the conveying member; a voltage application unit applying a voltage of n phases (n is a positive integer not less than one) to the electrodes so as to form a cloud of the toner and the toner is adhered to the latent image carrier so as to form a visualized toner image; a toner supply unit supplying the toner to the conveying member; and a height adjusting member adjusting a uniform height for a toner layer of the toner immediately before a development area on the conveying member in which development is performed.

Abstract: A liposome containing a regulatory cell ligand such as ?-galactosyl ceramide or ?-galactosyl ceramide is employed as the active ingredient of a drug for preventing or treating immune diseases etc.

Abstract: A developing unit for transferring toner onto a latent image on an image carrier so as to develop the latent image includes a toner carrier, an electric field generator and a separating force applicator. The toner carrier including a plurality of electrodes disposed along the surface thereof and insulated from each other transports the toner to a developing area facing the image carrier. The electric field generator applies a periodic voltage to the plurality of electrodes of the toner carrier so that an electric field is generated on the toner carrier surface to cause the toner charged to a given polarity and borne on the surface of the toner carrier to hop. The separating force applicator applies a separating force to separate the toner on the toner carrier from the surface thereof outside the developing area. The separating force applicator is disposed separately from the electric field generator.

Abstract: A developing apparatus including: a developer carrying member carrying a developer with which an electrostatic image on an image bearing member is developed; a developer supplying/removing member having a conductive member and an insulating member on the surface thereof, and provided apart from the developer carrying member to supply and remove the developer to and from the developer carrying member, and moving directions of the developer carrying member and the developer supplying/removing member being opposed in a developer supplying position; and an electric field producing device producing between the developer carrying member and the developer supplying/removing member an oscillating electric field, in which direct potentials of the conductive member and the developer carrying member are the same, or the direct potential of the conductive member, with respect to the direct potential of the developer carrying member, is on the opposite side to a normal charging polarity of the developer.

Abstract: A toner carrying member includes a plurality of electrodes arranged in a first direction intersecting with a second direction in which its surface moves. A voltage applying unit applies a bias to the electrodes such that an electric field direction is changed temporally in an alternate manner between adjacent electrodes. An adjusting member adjusts an amount of toner carried on the toner carrying member. A toner-cloud facilitating member includes a conductive member arranged between the toner supplying member and the adjusting member in the second direction in opposite to the toner carrying member.

Abstract: A development device includes an open-ended housing, a rotatable roller, an array of multiple primary electrodes, a voltage source, a sealing member, and a secondary electrode. The housing accommodates toner for application to the photoconductive surface through an end opening thereof. The roller has an outer circumferential surface to deliver the toner from within the housing to a development zone. The array of multiple primary electrodes are aligned with each other on the roller surface. The voltage source applies a periodic pulse voltage to at least a subset of the primary electrodes to generate an oscillating primary electric field. The sealing member seals clearance between the roller surface and an edge of the end opening downstream from the development zone. The secondary electrode generates a secondary electric field to force the toner from the sealing member toward the roller surface to prevent premature removal of the toner.

Abstract: A developing device includes a toner carrying member and an electric-field forming unit. The electric-field forming unit forms electric fields having different characteristics at a first area of the surface of the toner carrying member located within a developing area and a second area of the surface of the toner carrying member located out of the developing area such that a hopping height of toner at the first area is higher than that at the second area.

Abstract: A developing unit includes a brush member that includes a base member and a plurality of raisings that are erected on a surface of the base. The brush member traps toner within the raisings and causes a flicker movement in the raisings of the brush so that the toner trapped within the raisings is shaken and flown due to the flicker movement to the surface of a toner carrying member.

Abstract: The present invention provides a test system that specifically detects allergy, a test system that highly sensitively reflects aggravation of allergy and the like. More particularly, the present invention provides a diagnostic reagent, particularly a diagnostic reagent for allergy, or a reagent for detecting a mast cell and/or a blastogenic T cell, comprising one or more means for measuring CHD2, which is/are selected from the group consisting of a primer, a nucleic acid probe and an antibody; a test method for allergy, comprising measuring CHD2 expression in a biological sample obtained from an animal and evaluating allergy in the animal; a method for detecting a mast cell and/or a blastogenic T cell; and the like.

Abstract: A development device capable of suppressing the occurrence of development defects caused by partial damage to an electrode of a toner bearing roller. The development device is provided with a first electrode layer and a second electrode layer, which are laminated so as to overlap one another in a normal direction with respect to the surface of the roller part of the toner bearing roller. A plurality of openings, which are independently arranged in a matrix in both the roller surface movement direction and an orthogonal-to-movement direction which is the direction orthogonal thereto, are provided in, of these electrode layers, the second electrode layer existing in the upper location that is closer to the roller surface, over the entire latent image bearable area of a photosensitive body in the orthogonal-to-movement direction.

Abstract: The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue at position 35 with another amino acid in an amino acid sequence of SEQ ID NO:2; and (b) a polypeptide having an amino acid sequence having one or more substituted, deleted, inserted or added amino acids in positions except for positions 32 and 35, preferably positions 32 to 35 in the amino acid sequence of SEQ ID NO:2, and having an apoptosis-inducing activity.

Abstract: An image forming apparatus includes a toner-layer filling-rate lowering unit that causes a toner layer of toner images to be formed on an image carrier so that the toner layer has sufficient optical transparency for exposing and the toner-layer filling rate is set relatively low; and a toner rolling rate adjusting unit that rolls the toner images at a predetermined toner rolling rate in accordance with the toner-layer filling rate when the toner images are transferred to the transferring/fixing unit.

Abstract: A method of detecting a reactive metabolite which comprises steps of conducting a metabolic reaction of a test compound in the presence of two labeled nucleophiles, and detecting the label of the nucleophiles bound to the reactive metabolite, and a method of detecting a reactive metabolite which further comprises separating liquid layer using ammonium acetate to obtain an organic layer after the aforementioned reaction step are disclosed. In these detection methods, a reactive metabolite can be quantitatively detected by easy preparation. Furthermore, generation of a false positive signal can be prevented, and generation of a false negative signal can be decreased. Accordingly, screening of a test compound can be efficiently performed with higher accuracy.

Abstract: A developing device constituted to be capable of reliably making toner flare, and carrying out developing normally in the developing area, by preventing toner from adhering to the toner carrier. A developing device having a toner carrier which is disposed in opposition to a latent image carrier and which carries toner for developing an electrostatic latent image on the latent image carrier, the developing device including: a plurality of electrodes aligned at a predetermined interval within the toner carrier; voltage application means for applying a voltage to the electrodes so that the electric field between the plurality of electrodes varies with time, wherein the electric field between the electrodes causes the toner on the toner carrier to hop and form a cloud; and a toner adhesion prevention member that is provided upstream of a developing area where the latent image carrier is in opposition to the toner carrier and that prevents adhesion of toner to the toner carrier.