Abstract: The present disclosure relates to cytochrome P450 monooxygenases capable of oxidizing a monoterpenoid indole alkaloid (MIA) substrate and methods and uses thereof. The substrate may be a camptothecinoid, an evodiaminoid or an ellipticinoid. The disclosure further relates to method of producing hydroxylated monoterpenoid indole alkaloids, as well as derivatives and analogues of the produced hydroxylated monoterpenoid indole alkaloids. Pharmaceutical compositions comprising the hydroxylated monoterpenoid indole alkaloid derivatives are also provided.

Abstract: An eco-tile useful for promoting the growth of fauna and flora in an aquatic environment, the eco-tile including at least one type of cement; aggregates comprising at least two fine aggregates and coarse aggregates; and milled incineration sewage sludge ashes, wherein the at least two fine aggregates comprise dredged marine sediment, eco-concrete precursors thereof, and methods of use and preparation of the same.

Abstract: Methods, systems, and apparatuses include determining a set of data. The set of data includes multiple numerical ranges associated with an embedding and an attribute. The numerical range is sampled to obtain a sample value which is also associated with the embedding and the attribute. A set of sample value training data is generated, the set including the sample value, the associated embedding, and the associated attribute. A trained neural network prediction model is generated by applying a prediction model to the set of sample value training data. A set of input data is applied to the trained neural network prediction model. An output is determined by the trained neural network prediction model based on the set of input data. The output is a predicted range of values based on an output mean and an output standard deviation.

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

Abstract: In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non-viable organisms or non-viable cells, and methods of detecting contamination or infection.

Abstract: An apparatus for acquiring air quality data from removable and/or replaceable sensor, processing and storing the acquired data, and transmitting the processed data to backend server is enabled. The apparatus includes a microcontroller coupled with a Universal Sensor Interface (USI). The USI may include an element configured to transmit continuous electrical power to a removable and/or replaceable sensor, an element configured to transmit intermittent electrical power during time intervals corresponding to sensing intervals, an element configured to transmit an indication that the removable and/or replaceable sensor is currently coupled with the sensor interface, and one or more elements configured as a serial peripheral interface. A modular sensor system is thereby enabled, configurable to manage multiple removable and replaceable sensors such as air quality sensors.

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract: The invention provides compounds, including fluorescent nucleic acid dyes, and methods for use including nucleic acid detection. Further provided are kits, instruments and systems comprising compounds of the invention or adapted for use with compounds of the invention or other nucleic acid dyes.

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract: In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non-viable organisms or non-viable cells, and methods of detecting contamination or infection.

Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

Abstract: An apparatus for acquiring air quality data from removable and/or replaceable sensor, processing and storing the acquired data, and transmitting the processed data to backend server is enabled. The apparatus includes a microcontroller coupled with a Universal Sensor Interface (USI). The USI may include an element configured to transmit continuous electrical power to a removable and/or replaceable sensor, an element configured to transmit intermittent electrical power during time intervals corresponding to sensing intervals, an element configured to transmit an indication that the removable and/or replaceable sensor is currently coupled with the sensor interface, and one or more elements configured as a serial peripheral interface. A modular sensor system is thereby enabled, configurable to manage multiple removable and replaceable sensors such as air quality sensors.

Abstract: A method, system, and computer-readable medium for evicting cache lines that includes determining that a first cache line is to be evicted from a first Last Level Cache (LLC) partition of a partitioned LLC, and sending, based on the determination, a first notification to a second LLC partition of the partitioned LLC. The method may also include receiving, in response to the first notification, an available indication indicating that the second LLC partition is available as a designated victim cache partition; performing a selection of the second LLC partition as the designated victim cache partition; and evicting the first cache line to the second LLC partition based on the selection.

Abstract: A method and system for allocating data streams that includes receiving, at an allocator, a data stream. The data stream includes a memory address and data associated with the memory address. The method also includes examining, by the allocator, the data stream to make a determination that the data stream is a soft allocating data stream, and then sending, from the allocator based on the determination, a plurality of write probes to a plurality of caches, wherein each write probe of the plurality of write probes includes at least part of the memory address. Additionally, the method includes receiving, at the allocator in response to a write probe of the plurality of write probes, a cache line present acknowledgement from a cache of the plurality of caches, and directing, by the allocator in response to the cache line present acknowledgement, the data of the data stream to the cache.

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Abstract: The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: wherein Z? is a counterion, Y is a bridge unit permitting electron delocalization between F and ?, and F is a moiety having the structure: The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Abstract: A method, system, and computer-readable medium for evicting cache lines that includes determining that a first cache line is to be evicted from a first Last Level Cache (LLC) partition of a partitioned LLC, and sending, based on the determination, a first notification to a second LLC partition of the partitioned LLC. The method may also include receiving, in response to the first notification, an available indication indicating that the second LLC partition is available as a designated victim cache partition; performing a selection of the second LLC partition as the designated victim cache partition; and evicting the first cache line to the second LLC partition based on the selection.