Patents by Inventor Yefim Brun
Yefim Brun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240309120Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.Type: ApplicationFiled: December 14, 2023Publication date: September 19, 2024Inventors: RONG GUAN, MICHAEL D. GAGNON, NIKITA ILTCHENKO, YEFIM BRUN, LAURIE A. HOWE
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Publication number: 20240199766Abstract: Disclosed herein are compositions that comprise at least one oxidized polysaccharide derivative. Such an oxidized polysaccharide derivative can be produced by contacting a polysaccharide derivative under aqueous conditions with at least one agent that is capable of oxidizing the polysaccharide derivative. The polysaccharide derivative for oxidation has a degree of substitution (DoS) up to about 3.0 with at least one organic group. Further disclosed are methods of producing oxidized polysaccharide derivatives, as well as their use in various applications and products.Type: ApplicationFiled: February 17, 2022Publication date: June 20, 2024Inventors: Zhengzheng HUANG, ARJEN HOEKSTRA, SANDER BAS KLUIT, YEFIM BRUN, LAURIE A. HOWE
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Patent number: 11952435Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.Type: GrantFiled: March 16, 2023Date of Patent: April 9, 2024Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
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Patent number: 11932890Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.Type: GrantFiled: August 19, 2021Date of Patent: March 19, 2024Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Rong Guan, James Joshua Ohane, Nikita Iltchenko, Yefim Brun, Brian McCauley, Laurie A. Howe, Yougen Li
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Patent number: 11859022Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.Type: GrantFiled: October 25, 2019Date of Patent: January 2, 2024Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Rong Guan, Michael D. Gagnon, Nikita Iltchenko, Yefim Brun, Laurie A. Howe
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Publication number: 20230383014Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.Type: ApplicationFiled: March 16, 2023Publication date: November 30, 2023Inventors: KYLE HYUN CHANG KIM, YEFIM BRUN, LUCIA DANIELA IONESCU, JUAN DAVID LONDONO, JORGE MOK, JAMES JOSHUA OHANE, LEMUEL TONG
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Publication number: 20230235096Abstract: Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed.Type: ApplicationFiled: July 15, 2022Publication date: July 27, 2023Inventors: Rakesh Nambiar, Rong Guan, Qiong Cheng, Robert Dicosimo, Jayme L. Paullin, Yuanfeng Liang, Charles R. Powley, Yefim Brun
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Patent number: 11685907Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: GrantFiled: September 9, 2020Date of Patent: June 27, 2023Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Patent number: 11608388Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.Type: GrantFiled: November 5, 2020Date of Patent: March 21, 2023Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
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Patent number: 11390692Abstract: Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed.Type: GrantFiled: August 24, 2018Date of Patent: July 19, 2022Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Rakesh Nambiar, Rong Guan, Qiong Cheng, Robert Dicosimo, Jayme L. Paullin, Yuanfeng Liang, Charles R. Powley, Yefim Brun
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Publication number: 20220127654Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.Type: ApplicationFiled: August 19, 2021Publication date: April 28, 2022Inventors: Rong Guan, JAMES JOSHUA OHANE, NIKITA ILTCHENKO, YEFIM BRUN, BRIAN MCCAULEY, LAURIE A. HOWE, YOUGEN LI
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Patent number: 11098334Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.Type: GrantFiled: December 13, 2018Date of Patent: August 24, 2021Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Rong Guan, James Joshua Ohane, Nikita Iltchenko, Yefim Brun, Brian McCauley, Laurie A. Howe, Yougen Li
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Publication number: 20210130504Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.Type: ApplicationFiled: November 5, 2020Publication date: May 6, 2021Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
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Patent number: 10995435Abstract: Nonwoven webs comprising a water insoluble ?-(1,3?glucan) polymer and methods of forming the nonwoven webs are disclosed. The water insoluble ?-(1,3?glucan) polymer comprises 90% or greater ?-1,3-glycosidic linkages, less than 1% by weight of ?-1,3,6-glycosidic branch points, a number average degree of polymerization in the range of from 55 to 10,000, and a ratio of apparent DPw to true DPw in the range of from 2 to 10. The nonwoven webs can be used for personal hygiene wipes, filtration media, apparel, or other uses.Type: GrantFiled: November 8, 2016Date of Patent: May 4, 2021Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Natnael Behabtu, Joseph F. Roeske, Yefim Brun
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Patent number: 10988789Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.Type: GrantFiled: February 14, 2020Date of Patent: April 27, 2021Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Mark S. Payne, Yefim Brun, Hongxian He, Thomas Scholz
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Publication number: 20210108240Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: ApplicationFiled: September 9, 2020Publication date: April 15, 2021Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Publication number: 20200325513Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.Type: ApplicationFiled: February 14, 2020Publication date: October 15, 2020Inventors: MARK S. PAYNE, YEFIM BRUN, HONGXIAN HE, THOMAS SCHOLZ
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Patent number: 10793838Abstract: Compositions are disclosed herein comprising poly alpha-1,3-1,6-glucan with a weight average degree of polymerization (DPw) of at least 1000. This glucan polymer comprises at least 30% alpha-1,3 linkages and at least 30% alpha-1,6 linkages. Further disclosed are glucosyltransferase enzymes that synthesize poly alpha-1,3-1,6-glucan. Ether derivatives of poly alpha-1,3-1,6-glucan and methods of using such derivatives as viscosity modifiers are also disclosed.Type: GrantFiled: April 12, 2019Date of Patent: October 6, 2020Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLCInventors: Jayme L. Paullin, Mark S. Payne, T. Joseph Dennes, Yefim Brun, Rakesh Nambiar, Thomas H. Scholz
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Patent number: 10774352Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.Type: GrantFiled: May 22, 2018Date of Patent: September 15, 2020Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLCInventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
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Publication number: 20200262984Abstract: Disclosed herein are compositions comprising aggregates of insoluble alpha-glucan with alpha-1,3-glycosidic linkages. These aggregates have an average hydrodynamic radius of about 50 nm to about 300 nm, and a fractal dimension of about 1.6 to about 2.4. Insoluble alpha-glucan aggregates in some disclosed aspects are arborescent. Further disclosed are methods of preparing these compositions.Type: ApplicationFiled: November 6, 2018Publication date: August 20, 2020Inventors: Juan David Londono, Natnael Behabtu, David M. Scott, Yefim Brun