Patents by Inventor Yefim Brun

Yefim Brun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240309120
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.
    Type: Application
    Filed: December 14, 2023
    Publication date: September 19, 2024
    Inventors: RONG GUAN, MICHAEL D. GAGNON, NIKITA ILTCHENKO, YEFIM BRUN, LAURIE A. HOWE
  • Publication number: 20240199766
    Abstract: Disclosed herein are compositions that comprise at least one oxidized polysaccharide derivative. Such an oxidized polysaccharide derivative can be produced by contacting a polysaccharide derivative under aqueous conditions with at least one agent that is capable of oxidizing the polysaccharide derivative. The polysaccharide derivative for oxidation has a degree of substitution (DoS) up to about 3.0 with at least one organic group. Further disclosed are methods of producing oxidized polysaccharide derivatives, as well as their use in various applications and products.
    Type: Application
    Filed: February 17, 2022
    Publication date: June 20, 2024
    Inventors: Zhengzheng HUANG, ARJEN HOEKSTRA, SANDER BAS KLUIT, YEFIM BRUN, LAURIE A. HOWE
  • Patent number: 11952435
    Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
    Type: Grant
    Filed: March 16, 2023
    Date of Patent: April 9, 2024
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
  • Patent number: 11932890
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: March 19, 2024
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Rong Guan, James Joshua Ohane, Nikita Iltchenko, Yefim Brun, Brian McCauley, Laurie A. Howe, Yougen Li
  • Patent number: 11859022
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: January 2, 2024
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Rong Guan, Michael D. Gagnon, Nikita Iltchenko, Yefim Brun, Laurie A. Howe
  • Publication number: 20230383014
    Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
    Type: Application
    Filed: March 16, 2023
    Publication date: November 30, 2023
    Inventors: KYLE HYUN CHANG KIM, YEFIM BRUN, LUCIA DANIELA IONESCU, JUAN DAVID LONDONO, JORGE MOK, JAMES JOSHUA OHANE, LEMUEL TONG
  • Publication number: 20230235096
    Abstract: Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed.
    Type: Application
    Filed: July 15, 2022
    Publication date: July 27, 2023
    Inventors: Rakesh Nambiar, Rong Guan, Qiong Cheng, Robert Dicosimo, Jayme L. Paullin, Yuanfeng Liang, Charles R. Powley, Yefim Brun
  • Patent number: 11685907
    Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: June 27, 2023
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
  • Patent number: 11608388
    Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: March 21, 2023
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
  • Patent number: 11390692
    Abstract: Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: July 19, 2022
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Rakesh Nambiar, Rong Guan, Qiong Cheng, Robert Dicosimo, Jayme L. Paullin, Yuanfeng Liang, Charles R. Powley, Yefim Brun
  • Publication number: 20220127654
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.
    Type: Application
    Filed: August 19, 2021
    Publication date: April 28, 2022
    Inventors: Rong Guan, JAMES JOSHUA OHANE, NIKITA ILTCHENKO, YEFIM BRUN, BRIAN MCCAULEY, LAURIE A. HOWE, YOUGEN LI
  • Patent number: 11098334
    Abstract: Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: August 24, 2021
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Rong Guan, James Joshua Ohane, Nikita Iltchenko, Yefim Brun, Brian McCauley, Laurie A. Howe, Yougen Li
  • Publication number: 20210130504
    Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
    Type: Application
    Filed: November 5, 2020
    Publication date: May 6, 2021
    Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
  • Patent number: 10995435
    Abstract: Nonwoven webs comprising a water insoluble ?-(1,3?glucan) polymer and methods of forming the nonwoven webs are disclosed. The water insoluble ?-(1,3?glucan) polymer comprises 90% or greater ?-1,3-glycosidic linkages, less than 1% by weight of ?-1,3,6-glycosidic branch points, a number average degree of polymerization in the range of from 55 to 10,000, and a ratio of apparent DPw to true DPw in the range of from 2 to 10. The nonwoven webs can be used for personal hygiene wipes, filtration media, apparel, or other uses.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: May 4, 2021
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Natnael Behabtu, Joseph F. Roeske, Yefim Brun
  • Patent number: 10988789
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 27, 2021
    Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
    Inventors: Mark S. Payne, Yefim Brun, Hongxian He, Thomas Scholz
  • Publication number: 20210108240
    Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.
    Type: Application
    Filed: September 9, 2020
    Publication date: April 15, 2021
    Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
  • Publication number: 20200325513
    Abstract: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 15, 2020
    Inventors: MARK S. PAYNE, YEFIM BRUN, HONGXIAN HE, THOMAS SCHOLZ
  • Patent number: 10793838
    Abstract: Compositions are disclosed herein comprising poly alpha-1,3-1,6-glucan with a weight average degree of polymerization (DPw) of at least 1000. This glucan polymer comprises at least 30% alpha-1,3 linkages and at least 30% alpha-1,6 linkages. Further disclosed are glucosyltransferase enzymes that synthesize poly alpha-1,3-1,6-glucan. Ether derivatives of poly alpha-1,3-1,6-glucan and methods of using such derivatives as viscosity modifiers are also disclosed.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: October 6, 2020
    Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
    Inventors: Jayme L. Paullin, Mark S. Payne, T. Joseph Dennes, Yefim Brun, Rakesh Nambiar, Thomas H. Scholz
  • Patent number: 10774352
    Abstract: A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: September 15, 2020
    Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
    Inventors: Kevin D. Nagy, Susan Marie Hennessey, Yefim Brun, Michael Reichman
  • Publication number: 20200262984
    Abstract: Disclosed herein are compositions comprising aggregates of insoluble alpha-glucan with alpha-1,3-glycosidic linkages. These aggregates have an average hydrodynamic radius of about 50 nm to about 300 nm, and a fractal dimension of about 1.6 to about 2.4. Insoluble alpha-glucan aggregates in some disclosed aspects are arborescent. Further disclosed are methods of preparing these compositions.
    Type: Application
    Filed: November 6, 2018
    Publication date: August 20, 2020
    Inventors: Juan David Londono, Natnael Behabtu, David M. Scott, Yefim Brun