Patents by Inventor Yehenew Mekonnen Agazie

Yehenew Mekonnen Agazie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides and chemical compound for inhibition of SHP2 function
    Patent number: 7547760
    Abstract: The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to the phosphotyrosyl phosphatase domain of SHP2 thereby inhibiting the function of SHP2 both in vitro and in vivo. In addition, the inhibition of SHP2 may be useful as a treatment for human disease, and it has been shown that interfering with SHP2 function using the anti-SHP2 peptides and SEBA compounds reverses cell transformation and induces remission of preformed tumors in vivo demonstrating a possible treatment for cancer.
    Type: Grant
    Filed: July 3, 2006
    Date of Patent: June 16, 2009
    Assignee: West Virginia University
    Inventors: Yehenew Mekonnen Agazie, Peter M. Mannett
  • Peptides and chemical compound for inhibition of SHP2 function
    Publication number: 20090042788
    Abstract: The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to the phosphotyrosyl phosphatase domain of SHP2 thereby inhibiting the function of SHP2 both in vitro and in vivo. In addition, the inhibition of SHP2 may be useful as a treatment for human disease, and it has been shown that interfering with SHP2 function using the anti-SHP2 peptides and SEBA compounds reverses cell transformation and induces remission of preformed tumors in vivo demonstrating a possible treatment for cancer.
    Type: Application
    Filed: August 17, 2007
    Publication date: February 12, 2009
    Inventors: Yehenew Mekonnen Agazie, Peter Mico Gannett
  • Peptides and chemical compound for inhibition of SHP2 function
    Publication number: 20080004215
    Abstract: The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to the phosphotyrosyl phosphatase domain of SHP2 thereby inhibiting the function of SHP2 both in vitro and in vivo. In addition, the inhibition of SHP2 may be useful as a treatment for human disease, and it has been shown that interfering with SHP2 function using the anti-SHP2 peptides and SEBA compounds reverses cell transformation and induces remission of preformed tumors in vivo demonstrating a possible treatment for cancer.
    Type: Application
    Filed: July 3, 2006
    Publication date: January 3, 2008
    Inventors: Yehenew Mekonnen Agazie, Peter M. Mannett