Patents by Inventor Yehoshua Shachar
Yehoshua Shachar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890112Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11890111Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: March 6, 2020Date of Patent: February 6, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11883203Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: February 28, 2020Date of Patent: January 30, 2024Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 11567068Abstract: The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay device and sensor system; maintaining the functionalized detection lane of the SAW sensor dry until the sample is fluidically disposed in the detection lane; fluidically disposing the sample in the functionalized detection lane; removing fluid the functionalized detection lane to concentrate the sample in the functionalized detection lane to increase the probability of a specific antibody-antigen interaction; washing the functionalized detection lane so that substantially only the specific antigen-antibody interaction remains in the functionalized detection lane; removing fluid from the functionalized detection lane again; and measuring concentration of the sample while the functionalized detection lane is fluid-free.Type: GrantFiled: March 28, 2019Date of Patent: January 31, 2023Assignee: Autonomous Medical Devices Inc.Inventors: Yehoshua Shachar, Marlon S. Thomas
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Patent number: 11529443Abstract: An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.Type: GrantFiled: December 27, 2016Date of Patent: December 20, 2022Assignee: Cognos Therapeutics Inc.Inventors: Roger Kornberg, Yehoshua Shachar, Thomas Chen
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Patent number: 11358140Abstract: An cartridge is combined with a smart device which is capable of communicating with a network to perform a portable, fast, field assay of a small sample biological analyte. A closed microfluidic circuit for mixes the analyte with a buffer with functionalized magnetic beads capable of being specifically combined with the analyte. A detector communicates with the microfluidic circuit in which the mixed analyte, buffer and combined functionalized magnetic beads are sensed. A microcontroller is coupled to detector for controlling the detector and for data processing an output assay signal from the detector. A user interface communicates with the microcontroller for providing user input and for providing user output through the smart device to the network.Type: GrantFiled: October 4, 2018Date of Patent: June 14, 2022Assignee: Autonomous Medical Devices Inc.Inventors: Josh Yehoshua Shachar, Sam Gurley, Aaron Cipriano, Peter Yin, Rob Purnell, Marc Rocklinger, Ming Petrullo, Stelica Stelea, Marlon S. Thomas
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Patent number: 11224874Abstract: A field portable diagnostic apparatus uses a rotatable disk in which a microfluidic circuit is defined. The microfluidic circuit includes a centrifugal separation chamber receiving a sample to stratify the sample. A magnetic bead holding chamber is communicated to a mixing chamber, where mass amplifying functionalized magnetic-nanoparticles, held in a buffer solution and contained in the magnetic bead holding reservoir communicated to mixing chamber, are mixed with the separated fluid delivered to mixing chamber from the separation chamber. The functionalized magnetic nanoparticles conjugate with a target analyte in the sample. A magnet in proximity to a SAW chamber including a SAW detector draws the functionalized magnetic nanoparticles toward antibodies immobilized on the SAW sensor surface A wash reservoir is communicated to the SAW sensor chamber, and a cleanup/waste reservoir is communicated to the SAW chamber for receive fluid after it has passed through the SAW chamber.Type: GrantFiled: February 25, 2019Date of Patent: January 18, 2022Assignee: Autonomous Medical Devices Inc.Inventors: Josh Yehoshua Shachar, Sam Gurley, Aaron Cipriano, Peter Yin, Rob Purnell, Marc Rocklinger, Ming Petrullo, Stelica Stelea
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Patent number: 11156542Abstract: A surface acoustic wave (SAW) performs a rapid, label-free detection of biological species. Biosensing and detection of multiple analytes multiplexed by an array of sensing lanes is configured to enable bio-amplification using engineered DNA encoded libraries as the probe through a phage display procedure to enhance specificity, capture statistics for the detection, screening and analyzing of the analyte in vitro. A biochemical formulation minimizes the limit of detection (LOD) at a threshold magnitude on the order of a femtomolar concentration. Additional enhancement of the apparatus is achieved by use of an analog front end to amplify biochemical events.Type: GrantFiled: August 22, 2017Date of Patent: October 26, 2021Assignee: Autonomous Medical Devices Inc.Inventors: Yehoshua Shachar, Roger Kornberg
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Patent number: 11020741Abstract: A system and method for performing a portable, fast, field assay of a small sample biological analyte includes a microfluidic cartridge and a reader with which the microfluidic cartridge is selectively communicated. A closed microfluidic circuit mixes and recirculates the analyte with a buffer. A shear horizontal surface acoustic wave (SAW) detector communicates with the microfluidic circuit and has a plurality of channels including at least one functionalized sensing channel in which the mixed analyte and buffer is recirculated and sensed. Capture of the analyte is amplified by recirculation of the analyte and buffer, and detection is amplified by use of an all-purpose endospore display mass amplification.Type: GrantFiled: December 10, 2018Date of Patent: June 1, 2021Assignee: Autonomous Medical Devices Inc.Inventors: Yehoshua Shachar, Roger Kornberg
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Publication number: 20210106522Abstract: The present disclosure provides for a method of administering bortezomib into a brain tumor by a pump implanted in a brain of a subject. Also encompassed by the present disclosure-is- a method of administering a drug to a tumor in a central nervous system of a subject, the method comprising, delivering a therapeutically effective amount of the drug into a brain, tumor by a pump implanted in a brain of the subject, wherein administration of the drag to the subject in the central nervous system is contraindicated because of toxicity of the drug.Type: ApplicationFiled: January 29, 2019Publication date: April 15, 2021Inventors: Thomas CHEN, Yehoshua SHACHAR
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Publication number: 20200338325Abstract: The illustrated embodiments of the invention include an MRI compatible apparatus having: a refillable drug reservoir; a hermetically sealed, implantable chamber; a pump disposed in and hermetically sealed within the hermetically sealed, implantable chamber and fluidicly communicated to the drug reservoir; and control electronics disposed in and hermetically sealed within the hermetically sealed, implantable chamber and electrically communicated to the pump. The refillable drug reservoir, hermetically sealed, implantable chamber, pump and control electronics are MRI compatible.Type: ApplicationFiled: April 29, 2019Publication date: October 29, 2020Applicant: Cognos Theraeutics IncInventors: Yehoshua Shachar, Winston Wu
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Publication number: 20200309737Abstract: The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay and sensor system; maintaining the functionalized detection lane of the SAW sensor dry until the sample is fluidicly disposed in the detection lane; fluidicly disposing the sample in the functionalized detection lane; removing fluid the functionalized detection lane to concentrate the sample in the functionalized detection lane to increase the probability of a specific antibody-antigen interaction; washing the functionalized detection lane so that substantially only the specific antigen-antibody interaction remains in the functionalized detection lane; removing fluid from the functionalized detection lane again; and measuring concentration of the sample while the functionalized detection lane is fluid-free.Type: ApplicationFiled: March 28, 2019Publication date: October 1, 2020Applicant: Sensor Kinesis Corp.Inventors: Yehoshua Shachar, Marlon S. Thomas
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Patent number: 10786155Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: GrantFiled: May 12, 2017Date of Patent: September 29, 2020Assignee: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200214567Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 9, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200205663Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: March 6, 2020Publication date: July 2, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Publication number: 20200196868Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).Type: ApplicationFiled: February 28, 2020Publication date: June 25, 2020Applicant: Cognos Therapeutics Inc.Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
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Patent number: 10680419Abstract: An apparatus for autonomous cleaning of an electrical line includes: an inductive pick up coil concentrically disposed around the electrical line which pick up coil derives its power from the electrical line through inductive coupling; a drive motor having a driving wheel in contact with the electrical line; a power conditioning circuit for conditioning the inductively picked up power from the pick up coil, the drive motor being coupled to the power conditioning circuit; at least one rotating brush in contact with the electrical line for cleaning the electrical line; at least one brush motor coupled to the at least one brush to rotate the brush, the brush motor being coupled to the power conditioning circuit; and a control circuit for controlling the operation of the drive motor and brush motor, the control circuit coupled to the power conditioning circuit.Type: GrantFiled: December 21, 2017Date of Patent: June 9, 2020Inventors: Yehoshua Shachar, Martin Ellenbogen
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Publication number: 20190201900Abstract: A field portable diagnostic apparatus uses a rotatable disk in which a microfluidic circuit is defined. The microfluidic circuit includes a centrifugal separation chamber receiving a sample to stratify the sample. A magnetic bead holding chamber is communicated to a mixing chamber, where mass amplifying functionalized magnetic-nanoparticles, held in a buffer solution and contained in the magnetic bead holding reservoir communicated to mixing chamber, are mixed with the separated fluid delivered to mixing chamber from the separation chamber. The functionalized magnetic nanoparticles conjugate with a target analyte in the sample. A magnet in proximity to a SAW chamber including a SAW detector draws the functionalized magnetic nanoparticles toward antibodies immobilized on the SAW sensor surface A wash reservoir is communicated to the SAW sensor chamber, and a cleanup/waste reservoir is communicated to the SAW chamber for receive fluid after it has passed through the SAW chamber.Type: ApplicationFiled: February 25, 2019Publication date: July 4, 2019Applicant: Sensor Kinesis Corp.Inventors: Josh Yehoshua Shachar, Sam Gurley, Aaron Cipriano, Peter Yin, Rob Purnell, Marc Rocklinger, Ming Petrullo, Stelica Stelea
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Publication number: 20190199071Abstract: An apparatus for autonomous cleaning of an electrical line includes: an inductive pick up coil concentrically disposed around the electrical line which pick up coil derives its power from the electrical line through inductive coupling; a drive motor having a driving wheel in contact with the electrical line; a power conditioning circuit for conditioning the inductively picked up power from the pick up coil, the drive motor being coupled to the power conditioning circuit; at least one rotating brush in contact with the electrical line for cleaning the electrical line; at least one brush motor coupled to the at least one brush to rotate the brush, the brush motor being coupled to the power conditioning circuit; and a control circuit for controlling the operation of the drive motor and brush motor, the control circuit coupled to the power conditioning circuit.Type: ApplicationFiled: December 21, 2017Publication date: June 27, 2019Inventors: Yehoshua Shachar, Martin Ellenbogen
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Publication number: 20190176149Abstract: A system and method for performing a portable, fast, field assay of a small sample biological analyte includes a microfluidic cartridge and a reader with which the microfluidic cartridge is selectively communicated. A closed microfluidic circuit mixes and recirculates the analyte with a buffer. A shear horizontal surface acoustic wave (SAW) detector communicates with the microfluidic circuit and has a plurality of channels including at least one functionalized sensing channel in which the mixed analyte and buffer is recirculated and sensed. Capture of the analyte is amplified by recirculation of the analyte and buffer, and detection is amplified by use of an all-purpose endospore display mass amplification.Type: ApplicationFiled: December 10, 2018Publication date: June 13, 2019Inventors: Yehoshua Shachar, Roger Kornberg