Abstract: The present disclosure relates to a compound derivative containing a 6-7 bicyclic ring and use thereof. The compound according to the present disclosure can be effectively used in the prevention or treatment of diseases caused by PRMT5 by acting as a PRMT5 inhibitor.

Abstract: A semiconductor device according to an embodiment may include: a light emitting structure; a light transmitting electrode layer disposed on the light emitting structure; and a reflective layer disposed on the light transmitting electrode layer and including a plurality of first openings and a plurality of second openings. The semiconductor device according to the embodiment may include: a first electrode in contact with a first conductivity type semiconductor layer of the light emitting structure; and a second electrode in contact with the light transmitting electrode layer through the plurality of first openings.

Abstract: The present disclosure relates to a compound derivative containing a 6-7 bicyclic ring and use thereof. The compound according to the present invention can be effectively used in the prevention or treatment of diseases caused by PRMT5 by acting as a PRMT5 inhibitor.

Abstract: A hot-stamped article and method of manufacturing same use a tailor welded blank (TWB) method capable of controlling the microstructure of a weld portion to prevent fracture of the weld portion. The hot-stamped article is manufactured by welding a first sheet and a second sheet made of different kinds of materials to each other using the TWB method and hot-stamping a welded sheet. The first sheet and the second sheet have different upper austenite transformation temperatures (A3 temperatures), the first sheet and the second sheet are welded to each other via a weld portion, each of the first sheet and the weld portion has a composite structure comprising ferrite, bainite, and martensite, and the second sheet has a martensite structure.

Abstract: The present invention provides a target RNA detection method based on a dCas9/gRNA complex. A target RNA detection method according to the present invention can detect target RNA with the naked eye and without separate gene isolation and amplification steps, and, in particular, can rapidly and accurately detect target RNA through excellent target specificity and rapidity, and thus can exhibit excellent effects on the detection of various pathogens and/or viruses.

Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: A laser irradiation apparatus includes a stage on which a substrate is provided, a laser irradiation unit which irradiates a laser to the substrate on the stage, an image acquiring unit which acquires an image of a predetermined region of the substrate, and a control unit electrically connected to the laser irradiation unit and the image acquiring unit, where the control unit calculates a brightness value corresponding to an average value of grayscale values of the image provided from the image acquiring unit, compares a calculated brightness value with a reference brightness value, and outputs data on performance of the laser based on a result of comparing the calculated brightness value with the reference brightness value.

Abstract: Disclosed is a hot stamped part, which has improved toughness while maintaining high strength and high hardness, and a method for manufacturing the same. The hot stamped part is formed by performing hot stamping using an iron-based alloy, and includes a reinforced portion formed to have a martensite structure, a softened portion formed to have ferrite and bainite structures, and a transition portion formed between the reinforced portion and the softened portion. The reinforced portion, the transition portion and the softened portion are formed in the thickness direction of the hot stamped part.

Abstract: A hot stamping component and a manufacturing method thereof include: (a) preparing a blank including 0.27 to 0.33 wt % of carbon (C), more than 0 and 0.40 wt % or less of silicon (Si), 1.10 to 1.60 wt % of manganese (Mn), more than 0 and 0.030 wt % or less of phosphorus (P), more than 0 and 0.015 wt % or less of sulfur (S), 0.10 to 0.60 wt % of chromium (Cr), more than 0 and 0.1 wt % or less of titanium (Ti), and 0.0008 to 0.0050 wt % of boron (B); (b) heat-treating the blank; and (c) molding the heat-treated blank and cooling the molded blank. The component and method may stably provide high strength by minimizing hydrogen charging in a hot stamping manufacturing process and preventing hydrogen delayed fracture due to the hydrogen charging.

Abstract: The present disclosure relates to an isolated anti-FcRn antibody, which is an antibody binding to FcRn (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: The present invention relates to a composition for preventing or treating ischemia-reperfusion injury, the composition comprising an NADPH oxidase 1 (NOX1) inhibitor as an active ingredient, and more specifically, to a composition exhibiting prophylactic or therapeutic effects on ischemia reperfusion injury by suppressing the signaling of extracellular-signal-regulated kinase (ERK) by means of reactive oxygen species (ROS).

Abstract: A modular cosmetic product is provided that includes a container defining a cavity, an insert, a bezel, and a cosmetic product pan. The insert is adapted to be disposed within the cavity of the container and is at least partially constructed from a magnetic material. The bezel is also adapted to be at least partially disposed within the cavity of the container, and includes at least one opening. The cosmetic product pan is adapted to retain a cosmetic product and is at least partially disposed within the at least one opening of the bezel. The cosmetic product pan is at least partially constructed from a magnetic material such that it is urged towards the insert.

Abstract: The present disclosure relates to a compound derivative containing a 6-7 bicyclic ring and use thereof. The compound according to the present invention can be effectively used in the prevention or treatment of diseases caused by PRMT5 by acting as a PRMT5 inhibitor.

Abstract: A modular cosmetic product is provided that includes a container defining a cavity, an insert, a bezel, and a cosmetic product pan. The insert is adapted to be disposed within the cavity of the container and is at least partially constructed from a magnetic material. The bezel is also adapted to be at least partially disposed within the cavity of the container, and includes at least one opening. The cosmetic product pan is adapted to retain a cosmetic product and is at least partially disposed within the at least one opening of the bezel. The cosmetic product pan is at least partially constructed from a magnetic material such that it is urged towards the insert.

Abstract: Disclosed herein is a method of decoding an image. The method includes generating an inter prediction block by performing inter prediction with respect to a current block, generating an intra prediction block by performing intra prediction with respect to the current block, determining a first weight and a second weight, and generating a final prediction block by respectively applying the first weight and the second weight to the inter prediction block and the intra prediction block. The generating of the intra prediction block includes generating the intra prediction block using a predefined intra prediction mode.

Abstract: The present invention provides a novel compound having a protein kinase inhibition activity, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The compound, the stereoisomer thereof or the pharmaceutically acceptable salt thereof according to the present invention show a protein kinase inhibition activity, thus being effective in preventing or treating diseases related to protein kinase, such as cancer, autoimmune disease, neurological disease, metabolic disease, infection or the like.

Abstract: This document relates to materials and methods for treating fibrosis (e.g., pulmonary fibrosis). For example, this document provides methods for using one or more fatty acid synthase (FASN) inhibitors to treat a mammal having fibrosis (e.g., pulmonary fibrosis), and/or a complication associated with fibrosis (e.g., hypoxia caused by pulmonary fibrosis).

Abstract: Disclosed herein is a method of decoding an image. The method includes generating an inter prediction block by performing inter prediction with respect to a current block, generating an intra prediction block by performing intra prediction with respect to the current block, determining a first weight and a second weight, and generating a final prediction block by respectively applying the first weight and the second weight to the inter prediction block and the intra prediction block. The generating of the intra prediction block includes generating the intra prediction block using a predefined intra prediction mode.