Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

Abstract: The disclosure includes compounds of Formula (A): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12, j, k, m, n, Y, W, W1, W2, W3, V, L, Z1, Q1, Q2, Q3, and Q4, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neurodegenerative disease with these compounds.

Abstract: The disclosed is a target detection method, including: dividing a Doppler spectrum into N sub-bands, extracting energies of N signals from the Doppler spectrum; among the N signals, traversing position orders of signals corresponding to multiple transmission antennas; based on a respective total energy of the signals corresponding to the multiple transmission antennas under each position order, determining sub-bands to which the signals corresponding to the multiple transmission antenna belong. By traversing position orders of the signals of the multiple transmission antennas, a position order corresponding to a maximum total energy can be used to determine positions of the signals of the multiple transmission antennas in the sub-bands, ensuring the accuracy of the channel separation of each transmission antenna and thereby increasing target detection accuracy. Further disclosed are a signal processing method, a computer-readable storage medium, an integrated circuit, a radio device, and a terminal device.

Abstract: A method is provided for controlling a robot comprising a plurality of joints. The method comprises moving the robot from a first workspace to a second workspace based on controlling a first joint to rotate the robot along a fixed base, wherein the robot holds an object corresponding to a first tool center point (TCP); obtaining one or more images of the object while the robot is moving, using an image capturing device that moves along with the first joint of the robot; determining a second TCP based on the one or more images; controlling one or more other joints of the robot to adjust the object held by the robot according to the second TCP; and placing the object at a target location of the second workspace according to a refined TCP based on the adjustment result converging to a predetermined reference.

Abstract: The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

Abstract: A method for estimating 6D poses of objects includes (1) obtaining, using a camera, a low-resolution image and a high-resolution image from a viewpoint of a scene; (2) performing a pose detection on the low-resolution image to obtain class labels, region masks and initial poses of objects in the scene; (3) performing a pose refinement for each of the detected objects on the high-resolution image, including a) generating a cropped image from the high-resolution image based on a region mask of each detected object, and a rendered image of each detected object based on a CAD model, a current pose of each detected object and camera data; b) computing a refined object pose for each of the detected objects by comparing the cropped and rendered images; and c) updating the current pose of each detected object with the refined object pose; and (4) repeating step (3) until fulfilling a criterion.

Abstract: A portable blowing alcohol concentration measuring device is provided, including: a housing, a valve body, a first one-way valve, a second one-way valve and a container. The first one-way valve can be opened and closed between the air inlet of the housing and the valve body; a container is provided at the other end of the housing, and the housing and the container are spaced by a PTFE membrane; the second one-way valve has a suction port connected to a drainage port on the container. The opening and closing of the second one-way valve can make the passage between the suction port and the inside of the valve body to achieve a pass-through. By optimizing the structure and testing method, the alcohol in the exhaled gas is fully dissolved in the solution in the container, and the blood alcohol concentration can be obtained by direct measurement using the fitted function.

Abstract: A test equipment includes a selection register configured to store a selection index determined based on a selection command, a first tester channel including a first waveform driving device, and a second tester channel including a second waveform driving device. Each of the first tester channel and the second tester channel is multiplexed by a plurality of Device Under Test (DUTs). The first waveform driving device and the second waveform driving device are coupled to the selection register. The first waveform driving device is configured to generate, based on a driving source signal, a first waveform signal for driving multiple of first pins of the plurality of DUTs, and control, based on the selection index and a first bit map corresponding to the first tester channel, an output of the first waveform signal through the first tester channel.

Abstract: The present disclosure provides a preparation method of a broad bean protein and starch-based foamed hydrogel, and a use thereof in preparation of a vibration-damping packaging. The preparation method includes the following steps: stirring a broad bean protein solution with a concentration of 40 g/L to 60 g/L until foaming; under stirring, adding a sodium alginate-starch mixed solution in a volume twice a volume of the broad bean protein solution, followed by stirring until homogeneous; and adding calcium carbonate until a final concentration of the calcium carbonate reaches 10 g/L to 12 g/L, and further stirring thoroughly to produce the broad bean protein and starch-based foamed hydrogel, where in the sodium alginate-starch mixed solution, a concentration of sodium alginate is 22.5 g/L to 27.5 g/L, and a concentration of corn starch is 120 g/L to 160 g/L.

Abstract: The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Abstract: A data driving integrated circuit includes a digital-to-analog converter configured to receive a respective digital data signal from a timing controller and convert the respective digital data signal to a respective analog data signal, which is output to a display panel through a respective data line; an analog-to-digital converter configured to receive a respective analog sensing signal from a respective sensing line in the display panel and convert respective analog sensing signal to a respective digital sensing signal, which is output to the timing controller; a first sensing switch configured to control a connection between a first reference voltage line and the respective sensing line; a second sensing switch configured to control a connection between a second reference voltage line and the respective sensing line; and a third sensing switch configured to control the connection between the analog-to-digital converter and the respective sensing line.

Abstract: A detection system for detecting a bandwidth of an object to be tested is provided. The detection system includes a frequency-tunable laser module, a photoconductive semiconductor switch, and a digital acquisition system. The frequency-tunable laser module is configured to provide a first mixed frequency light and a second mixed frequency light, with a phase difference or a frequency difference between the first mixed frequency light and the second mixed frequency light. The photoconductive semiconductor switch is configured to receive the first mixed frequency light, the object to be tested is configured to receive the second mixed frequency light, and the photoconductive semiconductor switch and the object to be tested are coupled to output a mixed frequency signal. The digital acquisition system is configured to receive the mixed frequency signal to detect the bandwidth of the object to be tested. A detection method is also provided.

Abstract: Provided is an anti-Henipavirus monoclonal antibody having broad spectrum neutralization activity, wherein the antibody comprises a macaque variable region and a human constant region. The antibody of the present invention has good binding activity to both Nipah virus glycoprotein G and Hendra virus glycoprotein G, can effectively neutralize Nipahpseudovirus and Hendra pseudovirus, and can be used for preparing drugs for treating Henipavirus diseases.

Abstract: The disclosure provides compounds of Formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt, solvate, polymorph, tautomer, stereoisomer, an isotopic form, or a prodrug of said compound of Formula (I) or N-oxide thereof, wherein Z, Q1, Q3, Q4, Q5, Q6, Q7, R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, g, k, m, n, s, v, j, L, Z1, and, W are defined herein. Also disclosed is a method for treating a neoplastic disease and autoimmune disease with these compounds.

Abstract: The disclosure includes compounds of Formula (I), wherein each of Z, R0, R1, R2, R3, R4, R5, R6, R, L1, L2, L3, L4, L5, L6, Q1, Q2, W, m, n, r, and s, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

Abstract: A washing device includes a main machine; an inner container assembly which is arranged on the main machine and provided with a washing cavity, the inner container assembly being provided with a liquid outlet hole and a backflow opening which communicate with the washing cavity, bottom wall of the washing cavity inclining relative to horizontal direction, the backflow opening being in the side with lower height of the bottom wall of the washing cavity, and horizontal height of the liquid outlet hole being greater than that of the backflow opening; and a washing module including a water pump and a circulation pipeline, an input end of the water pump communicating with the backflow opening by the circulation pipeline while an output end thereof communicating with the washing cavity through the liquid outlet hole so as to spray cleaning water to a part to be washed in the washing cavity.

Abstract: The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

Abstract: The disclosure includes compounds of Formula (1) wherein each of R, R1, R2, R2A, R3, R4, R5, R6, R, L1, L2, L3, L4, L5, L6, Q1, Q2, Q3, m, n, r, s, and t, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

Abstract: Disclosed herein are compositions, systems, platforms, and kits comprising a tyramide-TCO and a tetrazine molecule linked to a detectable marker. Also disclosed are methods of using the compositions, systems, platforms, and kits to detect one or more target molecules, such as proteins or nucleic acids, in a sample.

Abstract: Methods of producing an alloy is provided. The methods involve can liquid-liquid interfaces reactions between gallium (Ga) or a liquid metal alloy and metal precursors. The resulting high entropy states are kinetically trapped by isothermal solidification. The methods can produce alloys with increased composition diversity (e.g., above about 20 elements), different morphology (e.g., 0-dimension, 2-dimension, 3-dimension), and crystallinity variations (e.g., single crystal, polycrystalline, mesocrystal, amorphous) under mild conditions (e.g., about room temperature to 80° C.). Alloys produced by the methods, high entropy mesocrystal alloys, and Ga-free high entropy alloys are also provided.