Abstract: Disclosed are a bispecific recombinant protein and a use thereof. The bispecific recombinant protein comprises a first functional binding region, a second functional binding region and an Fc region; the first functional binding region comprises a first chain and a second chain, and a C-terminus of the first chain and a C-terminus of the second functional binding region are separately connected to an N-terminus of the Fc region directly or by means of a linker sequence; and a C-terminus of the second chain is connected to an N-terminus of the second functional binding region directly or by means of a linker sequence. Further disclosed is an application of the recombinant protein in terms of anti-tumor, anti-virus, liver disease treatment, and other applications. The recombinant protein may significantly improve the killing efficacy of target cells while significantly reducing toxic side effects caused by binding to non-target cells, and has good safety and good freeze-thaw stability.

Abstract: A computer-implemented method for executing a hot upgrade process is provided. The computer-implemented method includes receiving a process upgrade request during executions of first and second tasks by an old container, determining that the process upgrade request affects the first task but not the second task, labeling the first task but not the second task and acting on the process upgrade request. The computer-implemented method further includes, based on the labeling, storing the first task by the old container and executing the second task by the old container, deleting the old container and instantiating a new container for transformation and execution of the first task.

Abstract: Layering of initially mixed granular dissimilar material components deposited by surface flow is realized by varying the relative angle of the flowing layer periodically with respect to the bulk of the pile formed. Layer thickness and extent can be controlled by varying the timing and extent of the surface variations. Variation in surface flow rates may be realized by varying the feed rate from an inlet to a collection base at a fixed feed location, varying the feed location relative to the collection base, tilting the collection base that is supporting the material, and reducing the pile repose angle using vibration or fluid flow through the base.

Abstract: Systems, methods, circuits, and devices for managing data transfers in semiconductor devices are provided. In one aspect, a method includes: selecting a first interface to receive higher-speed-type data at a first clock frequency; transferring the higher-speed-type data with a first speed along a first data path from the first interface through a first logic circuit to a driving circuit; outputting the higher-speed-type data by the driving circuit; selecting a second interface to receive lower-speed-type data at a second clock frequency that is same as the first clock frequency; transferring the lower-speed-type data with a second speed along a second data path from the second interface through a second logic circuit to the driving circuit, the first speed being higher than the second speed; and outputting the lower-speed-type data by the driving circuit.

Abstract: A care system and an automatic care method are provided. The care system is suitable for a care recipient. A physiological condition of the care recipient can be determined by sensors arranged around the care recipient, and a health condition of the care recipient can be determined through monitoring sleep disorders thereof. The care system receives a sound of the care recipient through a sound receiver, after removing a background sound, a sound of the care recipient can be obtained, and an image sensor is used to obtain an image of the care recipient to perform a motion detection, so as to obtain a posture image of the care recipient. Artificial intelligence technology can be used to build a care-taking warning prediction model to determine whether or not the status of the care recipient has reached a warning threshold.

Abstract: Intelligent process management is provided. A start time is determined for an additional process to be run on a worker node within a duration of a sleep state of a task of a process already running on the worker node by adding a first defined buffer time to a determined start time of the sleep state of the task. A backfill time is determined for the additional process by subtracting a second defined buffer time from a determined end time of the sleep state of the task. A scheduling plan is generated for the additional process based on the start time and the backfill time corresponding to the additional process. The scheduling plan is executed to run the additional process on the worker node according to the start time and the backfill time corresponding to the additional process.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: A shock absorber includes a threaded rod, a top positionally limiting seat and a bottom seat disposed at two ends of the threaded rod, a spring sleeved onto the threaded rod and abutted against the top positionally limiting seat, and a quick release fastening device including a threaded assembly and a quick release handle. The threaded assembly, which includes first and second threaded members detachably fastened to each other and screwed onto the threaded rod, is displaceable on the threaded rod by rotation to be abutted against the bottom seat or spring. The quick release handle is fixedly abutted against the first threaded member when at a tightly press position, and adapted to be hold by the user to rotate the threaded assembly when at a release position. The present invention has simple structure. The bottom seat or spring is adjustable fast and reliably without a special tool.

Abstract: A shock absorber includes a quick release tilted angle adjusting device including an adjusting seat with a first elongated groove and two second elongated grooves, a base unit with an axle in the first elongated groove and two threaded hole groups corresponding to the second elongated grooves respectively, and two quick release assemblies each including a quick release handle, a threaded pillar in the second elongated groove and the threaded hole group, and a pressing seat sleeved onto the threaded pillar for being tightly abutted on the adjusting seat by the quick release handle at a tightly press position. When the quick release handle is at a release position, the threaded pillar is rotatable by the user to enable the adjusting seat and the base unit to be relatively moved. The shock absorber is adjustable in tilted angle thereof conveniently and fast and prevented from making abnormal noise.

Abstract: A semiconductor includes a substrate. A gate structure is disposed on the substrate. A liner oxide contacts a side of the gate structure. A silicon oxide spacer contacts the liner oxide. An end of the silicon oxide spacer forms a kink profile. A silicon nitride spacer contacts the silicon oxide spacer and a tail of the silicon nitride spacer covers part of the kink profile. A stressor covers the silicon nitride spacer and the substrate.

Abstract: Provided are an anti-?Klotho antibody and the use thereof. The anti-?Klotho antibody can be used for treating ?Klotho-mediated or ?Klotho-FGFR1c-FGF21-mediated diseases, especially abnormal metabolic diseases, such as type 1 diabetes, type 2 diabetes, dyslipidemia, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, metabolic syndrome or obesity.

Abstract: Disclosed herein are system, method, and computer program product embodiments for visualizing sound coverage in a venue. An embodiment operates by receiving audio content from an audio source, determining audio signal properties of the audio content, where the audio signal properties comprise one or more spectral, temporal, spatial components (e.g., energy, spectrum or directivity), receiving an audio system configuration of loudspeakers or sound beams of a venue, visualizing the audio signal based on a mapping of an intersection of a unique volumetric beam of colored light, representing the spectral, temporal, spatial components, with a portion of the venue and displaying the visualized audio signal as a virtual representation of sound coverage of the portion of the venue.

Abstract: A method for fabricating semiconductor device includes the steps of first providing a substrate having a first region and a second region, forming a first bottom barrier metal (BBM) layer on the first region and the second region, forming a first work function metal (WFM) layer on the first BBM layer on the first region and the second region, and then forming a diffusion barrier layer on the first WFM layer.

Abstract: In some examples, a display device includes a panel, a scaler circuit, and a backlight control circuit. In some examples, the scaler circuit receives a panel identification from the panel and determines a backlight module driving configuration based on the panel identification. In some examples, the backlight control circuit receives the backlight module driving configuration from the scaler circuit and controls a backlight for the panel based on the backlight module driving configuration.

Abstract: Systems, methods, circuits, and devices for managing data transfers in semiconductor devices are provided. In one aspect, an integrated circuit includes: a first interface for receiving higher-speed-type data, a second interface for receiving lower-speed-type data, a first logic circuit coupled to the first interface, a second logic circuit coupled to the second interface, and a driving circuit separately coupled to the first logic circuit and the second logic circuit. The first data interface, the first logic circuit, and the driving circuit are arranged in series to form a first data path for transferring the higher-speed-type data with a first speed. The second data interface, the second logic circuit, and the driving circuit are arranged in series to form a second data path for transferring the lower-speed-type data with a second speed. The first speed is higher the second speed.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: A driving mechanism for moving an optical element is provided, including a fixed part, a movable part, a driving assembly, and a first guiding member connected between the fixed part and the movable part. The optical element is disposed on the movable part, and the driving assembly drives the movable part to move relative to the fixed part. The first guiding member is configured for guiding the movable part to move relative to the fixed part.

Abstract: Embodiments of the present disclosure are directed towards coated fertilizer granule compositions that include three polyurethane layers and two wax layers.

Abstract: A method for fabricating semiconductor device includes the steps of first providing a substrate having a first region and a second region, forming a first bottom barrier metal (BBM) layer on the first region and the second region, forming a first work function metal (WFM) layer on the first BBM layer on the first region and the second region, and then forming a diffusion barrier layer on the first WFM layer.

Abstract: A heat pump system having a common refrigerant flow path split coupled to heating mode first and second refrigerant streams. In the common refrigerant flow path, a compressor is coupled to receive refrigerant from the heating mode first refrigerant stream and the heating mode second refrigerant stream. A refrigerant-to-refrigerant heat exchanger couples heat between the heating mode first refrigerant stream and the heating mode second refrigerant stream. A first refrigerant-air heat exchanger and a second refrigerant-air heat exchanger in a second air flow conduit is coupled to receive a first air flow from a first refrigerant-air heat exchanger in a first air flow conduit.