Abstract: A tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet microfluidic chip; a valve control system connected to the tubing-free, sample-to-droplet microfluidic chip; a vacuum system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip; and a droplet formation pressure system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip. A microfluidic chip for a tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet interface section; a droplet mixing section in fluid connection with the tubing-free, sample-to-droplet interface section to received droplets therefrom; an incubation section in fluid connection with the droplet mixing section to receive droplets therefrom; and a detection section in fluid connection with the incubation section to receive droplets therefrom.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: The present invention relates to a polymer latex composition, to a method for the preparation of such polymer latex composition, to a compounded latex composition comprising said polymer latex composition, to the use of said polymer latex composition, to a method for making dip-molded articles, to a method for the production of a continuous elastomeric film and for making an elastomeric article, to a method for repairing or reforming an elastomeric film or an article and to articles made by using said polymer latex composition.

Abstract: A game controller includes a first control handle and a second control handle. The first control handle includes a first handle portion and a recess mount portion disposed on the first handle portion. The second control handle includes a second handle portion and a protrusion mount portion disposed on the second handle portion. The protrusion mount portion is slidably accommodated in the recess mount portion. When the game controller is in a combined mode, the first handle portion and the second handle portion are combined with each other for being cooperated with a game host. When the game controller is in a separated mode, the first handle portion is separated from the second handle portion so as to form an installation space between the first handle portion and the second handle portion for a mobile device to be installed therein.

Abstract: The present invention relates to a polymer latex composition, to a method for the preparation of such a polymer latex composition, to the use of said polymer latex composition for the production of elastomeric articles, to a compounded latex composition comprising said polymer latex composition, to a method for making dip-molded articles, to a method for making elastomeric articles and to articles made by using said polymer latex composition.

Abstract: A game controller includes a first control handle, a second control handle and a stretchable assembly. The stretchable assembly is in a symmetrical configuration and is connected to the first control handle and the second control handle, the first control handle and the second control handle are slidable relative to each other via the stretchable assembly so as to be in a combined mode or a separated mode. When the game controller is in the combined mode, the first control handle and the second control handle are jointed with each other for being cooperated with a game console. When the game controller is in the separated mode, the first control handle and the second control handle are spaced apart from each other so as to form an installation space between the first control handle and the second control handle for a mobile device to be installed therein.

Abstract: A display device and a bezel thereof are provided. The display device includes a display panel and a bezel. The display panel has a first surface and a second surface. The first surface includes at least one pixel pad section, and the second surface includes at least one circuit pad section. The bezel includes a first surface connecting portion, a second surface connecting portion and at least one conductive wire. The edge of the display panel having the pixel pad section and the circuit pad section is accommodated between the first surface connecting portion and the second surface connecting portion. Each conductive wire has a first end and a second end. The first end is disposed on the first surface connecting portion and the second end is disposed on the second surface connecting portion. The part of the first connecting portion having the first end corresponds to the pixel pad section, and the part of the second connecting portion having the second end corresponds to the circuit pad section.

Abstract: The present invention relates to method for the production of a continuous elastomeric film and to continuous elastomeric films and elastomeric articles obtained thereby, where the method comprises: B) providing an aqueous polymer latex composition comprising: (I) particles of a latex polymer obtained by free-radical emulsion polymerization of a mixture of ethylenically unsaturated monomers, the particles bearing a plurality of functional groups, and (II) a crosslinking component comprising a plurality of functional groups at least one thereof being reactive with the functional groups on the latex polymer particles; B) forming from the aqueous polymer latex composition a continuous polymer film; C) optionally drying the continuous polymer film obtained in step B); D) curing the continuous polymer film obtained in step B) or C) to form a continuous elastomeric film; and E) optionally rolling the continuous elastomeric film obtained in step D) into a roll.

Abstract: The present invention provides a control method of a processor, wherein the control method comprises the steps of: transmitting image data of a first frame to an integrated circuit, wherein the first frame corresponds to a first frame rate; determining a second frame rate of a second frame next to the first frame; determining if a difference between the second frame rate and the first frame rate belongs to a large scale frame rate adjustment or a small scale frame rate adjustment; if the difference between the second frame rate and the first frame rate belongs to the large scale frame rate adjustment, using a first mode to transmit image data of the second frame; and if the difference between the second frame rate and the first frame rate belongs to the small scale frame rate adjustment, using a second mode to transmit image data of the second frame.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The disclosure provides a three-dimensional (3D) image classification method and apparatus, a device, and a storage medium. The method includes: obtaining a 3D image, the 3D image including first-dimensional image information, second-dimensional image information, and third-dimensional image information; extracting a first image feature corresponding to planar image information from the 3D image; extracting a second image feature corresponding to the third-dimensional image information from the 3D image; fusing the first image feature and the second image feature, to obtain a fused image feature corresponding to the 3D image; and determining a classification result corresponding to the 3D image according to the fused image feature corresponding to the 3D image.

Abstract: A data serializer, a latch data device using the same and a controlling method thereof are provided. The data serializer includes at least one data buffer and a de-skew buffer. The data buffer at least receives an inputting data and a controlling signal. An outputting signal and a complementary outputting signal, which is complementary to the outputting signal, are formed when the controlling signal is at a predetermined level. The de-skew buffer receives the complementary outputting signal to accelerate or slow down forming the outputting signal.

Abstract: Disclosed herein are system, method, and computer program product embodiments for visualizing sound coverage in a venue. An embodiment operates by receiving audio content from an audio source, determining audio signal properties of the audio content, where the audio signal properties comprise one or more spectral, temporal, spatial components (e.g., energy, spectrum or directivity), receiving an audio system configuration of loudspeakers or sound beams of a venue, visualizing the audio signal based on a mapping of an intersection of a unique volumetric beam of colored light, representing the spectral, temporal, spatial components, with a portion of the venue and displaying the visualized audio signal as a virtual representation of sound coverage of the portion of the venue.

Abstract: A Bluetooth earphone includes an antenna and a circuit board. The circuit board includes a first grounding branch and a second grounding branch. The first grounding branch is connected in series to a first switch, and the second grounding branch is connected in series to a second switch. When the first switch is on, the first grounding branch serves as a current return path of the antenna. When the second switch is on, the second grounding branch serves as a current return path of the antenna. By controlling the on or off state of the first switch and the second switch, the Bluetooth earphone can switch ground structures of the antenna and select different current return paths for the antenna, to switch radiation patterns of the antenna.

Abstract: Intelligent process management is provided. A start time is determined for an additional process to be run on a worker node within a duration of a sleep state of a task of a process already running on the worker node by adding a first defined buffer time to a determined start time of the sleep state of the task. A backfill time is determined for the additional process by subtracting a second defined buffer time from a determined end time of the sleep state of the task. A scheduling plan is generated for the additional process based on the start time and the backfill time corresponding to the additional process. The scheduling plan is executed to run the additional process on the worker node according to the start time and the backfill time corresponding to the additional process.

Abstract: Systems and methods for rendering spatial audio in accordance with embodiments of the invention are illustrated. One embodiment includes a spatial audio system, including a primary network connected speaker, including a plurality of sets of drivers, where each set of drivers is oriented in a different direction, a processor system, memory containing an audio player application, wherein the audio player application configures the processor system to obtain an audio source stream from an audio source via the network interface, spatially encode the audio source, decode the spatially encoded audio source to obtain driver inputs for the individual drivers in the plurality of sets of drivers, where the driver inputs cause the drivers to generate directional audio.

Abstract: An electric lock with electric and manual unlock mode, comprising: a case combining with a side plate and a case cover; a latch bolt, a latch bolt shaft and a latch bolt spring, the front end of the latch bolt shaft is combined with a blocking member, and the blocking member uses the elastic force of the latch bolt spring to stick out of the side plate to lock, when the external force applied to the latch bolt shaft is sufficient to resist the elastic force of the latch bolt spring, the blocking member will retract into the side plate to unlock; a unlock crank, having an electric push member and a manual push member, and a push member relative to the latch bolt shaft; and a linear actuator and an actuating arm, the outer end of the actuating arm is combined with a push block relative to the electric push member, and a push block return spring is set relative to the push block.

Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer.

Abstract: A method for controlling a fan in a fan start-up stage including a first time period and a second time period comprises the following steps of: during the first time period, continuously providing a first driving signal to drive the fan; and during the second time period, continuously providing a second driving signal to drive the fan; wherein, the signal value of the first driving signal gradually decreases until being equal to the signal value of the second driving signal. Wherein the signal value of the first driving signal non-linearly decreases, the signal value of the second driving signal is an unchanged value. Wherein, the first time period and the second time period are adjusted for a different fan but the sum of the first time period and the second time period is always the same. A fan is also disclosed.