Abstract: The present disclosure provides a method and a system for determining the equivalence of the DRM data set and the DRC data set. The system retrieves a DRM data set and a DRC data set, and transforms the DRM data set and the DRC data set into a first data structure node and a second data structure node respectively. The system determines whether the first data structure node and the second data structure node are equivalent according to a data structure node comparison model.

Abstract: Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.

Abstract: A low distortion triangular wave generator circuit generates a triangular wave signal by performing integration on an integration capacitor via a charging current and a discharging current during a charging period and a discharging period within a switching period of an external clock signal. A time length of the charging period is identical to a time length of the discharging period. A common mode related signal related to a common mode characteristic of the triangular wave signal is generated. An adjusting signal is generated according to a difference between the common mode related signal and a predetermined DC (direct current) level. The adjusting signal adjusts at least one of the charging current and the discharging current via feedback mechanism such that the triangular wave signal is a symmetrical triangular wave, and an average voltage of the triangular wave signal is equal to a target DC level.

Abstract: A low distortion triangular wave generator circuit generates a triangular wave signal by performing integration on an integration capacitor via a charging current and a discharging current during a charging period and a discharging period within a switching period of an external clock signal. A time length of the charging period is identical to a time length of the discharging period. A common mode related signal related to a common mode characteristic of the triangular wave signal is generated. An adjusting signal is generated according to a difference between the common mode related signal and a predetermined DC (direct current) level. The adjusting signal adjusts at least one of the charging current and the discharging current via feedback mechanism such that the triangular wave signal is a symmetrical triangular wave, and an average voltage of the triangular wave signal is equal to a target DC level.

Abstract: The present disclosure provides a method and a system for determining the equivalence of the DRM data set and the DRC data set. The system retrieves a DRM data set and a DRC data set, and transforms the DRM data set and the DRC data set into a first data structure node and a second data structure node respectively. The system determines whether the first data structure node and the second data structure node are equivalent according to a data structure node comparison model.

Abstract: The present disclosure provides a method and a system for determining the equivalence of the DRM data set and the DRC data set. The system retrieves a DRM data set and a DRC data set, and transforms the DRM data set and the DRC data set into a first data structure node and a second data structure node respectively. The system determines whether the first data structure node and the second data structure node are equivalent according to a data structure node comparison model.

Abstract: The present invention provides a method for enhancement of the uniform reaction on the porous materials. Comparing with the conventional Western blotting method, the present invention is successfully demonstrated capability on increasing the immune-detection signal intensity and only needs one order of magnitude less of the processing time by applying two orders of magnitude less dosage usage-amount compared to those operated in the conventional method.

Abstract: [Problem to be Solved] To provide a compound for removing pluripotent cells from a cell population potentially containing the pluripotent cells. [Solution] A polyphenylalanine derivative is contacted with a cell population of interest.

Abstract: Disclosed herein are fibrillar molecular aggregates, which are morphologically and phenotypically similar to oligomers of aberrant proteins. The molecular aggregates, formed by self-assembly of small hydrophobic molecules, prevent the growth of microtubules. This unprecedented mechanism of “self-assembly to interfere with self-organization” allows inhibition of the growth of cancer cells.

Abstract: The present invention provides a method for enhancement of the uniform reaction on the porous materials. Comparing with the conventional Western blotting method, the present invention is successfully demonstrated capability on increasing the immune-detection signal intensity and only needs one order of magnitude less of the processing time by applying two orders of magnitude less dosage usage-amount compared to those operated in the conventional method.

Abstract: This invention proposes using a feed forward quasi universal converter for energy harvesters, and uses it to power IoTs (Internet of things). A typical DC to DC converter uses voltage feedback control or current feedback control. It is not easy for the input impedance to closely match the output impedance of the power source. In the meantime, it also meets its output voltage and power targets. The Feed forward Quasi Universal Converter proposed in this invention controls the input impedance and the output voltage/power within a range that meets the design targets. It is also achieved with a simple electronic adjustment when the source impedance changes or the output requirements change. It has the potential to shorten the IoTs system industry's product development cycle, reduce installation and maintenance costs and facilitate the adoption of hybrid energy sources.

Abstract: [Problem to be Solved] To provide a compound for removing pluripotent cells from a cell population potentially containing the pluripotent cells. [Solution] A polyphenylalanine derivative is contacted with a cell population of interest.

Abstract: This invention proposes using a feed forward quasi universal converter for energy harvesters, and uses it to power IoTs (Internet of things). A typical DC to DC converter uses voltage feedback control or current feedback control. It is not easy for the input impedance to closely match the output impedance of the power source. In the meantime, it also meets its output voltage and power targets. The Feed forward Quasi Universal Converter proposed in this invention controls the input impedance and the output voltage/power within a range that meets the design targets. It is also achieved with a simple electronic adjustment when the source impedance changes or the output requirements change. It has the potential to shorten the IoTs system industry's product development cycle, reduce installation and maintenance costs and facilitate the adoption of hybrid energy sources.

Abstract: Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.

Abstract: Disclosed is a general methodology to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

Abstract: A switching converter includes an input end, N output ends, an inductor, a charging/discharging control unit, an energy distribution control unit and a logic control unit. The input end is utilized for receiving an input voltage. The N output ends are utilized for outputting N output voltages. The inductor is utilized for storing energy of the input voltage. The charging/discharging control unit and the energy distribution control unit are respectively utilized for generating a charging/discharging control signal and N energy distribution control signals to control a charging switch and N output switches according to the N output voltages, wherein the i-th distribution control signal is corresponding to the i-th output voltage signal to the N-th output voltage signal. The logic control unit is utilized for generating the charging switch control signal and N output switch control signals according to the charging/discharging control signal and the N energy distribution control signals.

Abstract: Disclosed is a general methodology to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.

Abstract: A multiphase clock divider includes: a reference clock generator for generating a plurality of reference clocks; and at least one output clock generator including a first multiplexer for selecting to output a selected reference clock, a second multiplexer for selecting to output a first selected input clock, a third multiplexer for selecting to output a second selected input clock, a first flip-flop for outputting a first sampling clock according to the selected reference clock and the first selected input clock, a second flip-flop for outputting a second sampling clock according to the first sampling clock and the second selected input clock, and a fourth multiplexer for selecting to output the first sampling clock or the second sampling clock to generate an output clock.

Abstract: A multiphase clock divider includes: a reference clock generator for generating a plurality of reference clocks; and at least one output clock generator including a first multiplexer for selecting to output a selected reference clock, a second multiplexer for selecting to output a first selected input clock, a third multiplexer for selecting to output a second selected input clock, a first flip-flop for outputting a first sampling clock according to the selected reference clock and the first selected input clock, a second flip-flop for outputting a second sampling clock according to the first sampling clock and the second selected input clock, and a fourth multiplexer for selecting to output the first sampling clock or the second sampling clock to generate an output clock.

Abstract: Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel.