Abstract: The present invention generally relates to sensitizer compounds and their use to sensitize cancer and/or pre-cancerous cells of certain cancers to treatment with certain resistance-prone therapeutics used in cancer therapy. In embodiments, the conjugates of particular esters or amides of Near Infrared Dyes, are used as sensitizers to avoid or overcome therapeutic resistance once formed. In embodiments, the sensitizers include conjugates with Cisplatin, Simvastatin, Artemisinin, platin-based compounds or statins. In embodiments, the resistance prone cancer therapeutics include cisplatin, gemcitabine, doxorubicin, paclitaxel, docetaxel, and platin-based compounds. These may be administered in combination with the sensitizer, or the sensitizer itself may comprise an therapeutic-derived moiety conjugated to the sensitizer, for example as is the case for dye-CIS conjugated sensitizers. Alternatively, the sensitizer may be co-administered with one or more therapeutic.

Abstract: Disclosed are a display panel and a display apparatus. The display panel is divided into a display area and a non-display area surrounding the display area. The non-display area is provided with a fan-out area. The display panel includes: a substrate and a first power wire arranged on the substrate. The first power wire is located in the non-display area. At least part of an orthographic projection of the first power wire on the substrate is located in the fan-out area. The first power wire is provided with a plurality of first hollow parts in a direction perpendicular to the substrate.

Abstract: An endoscope comprising a camera handle used to fix the camera lens and a wired connector; the camera handle comprises of an outer shell, an end cap and an inner shell; an sensing element is provided inside the inner shell; a lens group is provided between the sensing element and the end cap; the inner shell is fixedly connected with the outer shell through assembling components; the outer shell is fixedly connected with the inner shell through fixing components; a light hole corresponding to the position of the sensing element is cut in the middle of the end cap.

Abstract: Disclosed a display panel comprising: a base substrate and a plurality of sub-pixels located on the base substrate; and each sub-pixel includes: a semiconductor layer located on the base substrate and including a first active layer of an initialization transistor, a second active layer of a reset transistor and a third active layer of a data writing transistor; a first conductive layer located on a side of the semiconductor layer and including a data signal line extending in a first direction; and a second conductive layer located on the base substrate and including a drive gate of a drive transistor; where the drive gate is electrically connected to a first conductive region of the first active layer; and an orthographic projection of the second active layer on the base substrate is located between an orthographic projection of the first active layer and an orthographic projection of the data signal line.

Abstract: Provided here are cells engineered for therapeutic purposes to express multiple proteins, including an anti-BCMA (B cell maturation antigen), anti-CD3 bispecific antibody. Also provided are new anti-BCMA, anti-CD3 bispecific antibodies with associated sequences. Further disclosed is a mesenchymal stem cell (MSC) comprising an exogenous mRNA encoding an anti-BCMA and anti-CD3 antibody, and an exogenous mRNA encoding a single-chain interleukin-12 (IL-12) fusion protein.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An oxygen generator with an oxygen-producing having a center bore, including: an impact-activated ignition mechanism, an end cover, a cylinder, a bell-shaped hood, a thermally insulating inner cylinder, an oxygen-producing column, a thermally insulating material, a support bowl, a gas purification material, a safety valve, an isolation net, an oxygen-discharging end cover and an oxygen-discharging joint. The cylinder is provided with the end cover at one end; the impact-activated ignition mechanism is fixed on the end cover; the oxygen-producing column is coaxially located with the cylinder, one end of the oxygen-producing column is connected to the impact-activated ignition mechanism, and the other end of the oxygen-producing column is connected to the support bowl; the support bowl is connected to the isolation net; the thermally insulating inner cylinder is arranged on the outside of the oxygen-producing column and the thermally insulating material.

Abstract: A control information transmission method, apparatus, device, and storage medium; a terminal device obtains configuration information, then monitors any of the at least one downlink control information format according to the configuration information; the configuration information is used for configuring an available downlink control information format of the terminal device, the available downlink control information format includes a first downlink control information format, the first downlink control information format being used for simultaneously scheduling a plurality of carriers.

Abstract: Embodiments of the present application are related to a method and apparatus for physical uplink control channel (PUCCH) transmission. An exemplary method of the present application includes: receiving a plurality of joint or UL common TCI states to be used for PUCCH transmission associated with a plurality of CORESETPoolIndex values, wherein each TCI state of the plurality of TCI states is separately indicated by a PDCCH transmitted in a control source set (CORESET) associated with a CORESETPoolIndex value of the plurality of CORESETPoolIndex values; and for a PUCCH resource associated with a corresponding CORESETPoolIndex value of the plurality of CORESETPoolIndex values, transmitting the PUCCH resource according to a TCI state indicated by a PDCCH transmitted in a CORESET associated with the corresponding CORESETPoolIndex value.

Abstract: A touch panel includes: a first touch electrode including a first corner protrusion and first side protrusions including an adjacent-type first side protrusion, and a second touch electrode including a second corner protrusion and second side protrusions including an adjacent-type second side protrusion. The first side protrusion includes a second side sub-protrusion. The first corner protrusion includes a second corner sub-protrusion. The second side protrusion includes a fourth side sub-protrusion. The second corner protrusion includes a fourth corner sub-protrusion. The area of at least one of the second corner sub-protrusion and the second side sub-protrusion of the adjacent-type first side protrusion is smaller than that of the other second side sub-protrusion; and/or the area of at least one of the fourth corner sub-protrusion and the fourth side sub-protrusion of the adjacent-type second side protrusion is smaller than that of the other fourth side sub-protrusion.

Abstract: Apparatuses, methods, and systems are disclosed for configuring multiple subarrays for a reconfigurable intelligent surface device. The method (1200) includes transmitting a control signal to a reconfigurable intelligent surface device to configure a plurality of subarrays; where in the control signal comprises: a number of subarrays corresponding to the plurality of subarrays; and phase control parameters of each subarray of the plurality of subarrays (1202).

Abstract: A display substrate and a display apparatus are provided, wherein the display substrate includes a display area and a non-display area, wherein the non-display area includes a first bezel area and a transition area, the transition area including a first transition area; the display substrate includes a light emitting drive circuit, a scanning drive circuit, and a control drive circuit; the light emitting drive circuit includes multistage light emitting shift registers, the scanning drive circuit includes multistage scanning shift registers, and the control drive circuit includes multistage control shift registers; the first bezel area includes a first circuit group, the first transition area includes a second circuit group, and the first circuit group and the second circuit group include a Q1-stage light emitting shift register, a Q2-stage scanning shift register, and a Q3-stage control shift register.

Abstract: A modular multilevel converter system, and a voltage detection method and an open-circuit fault diagnosis method thereof are disclosed. The modular multilevel converter system includes: N sub-modules sequentially cascaded, where N is an integer greater than or equal to 2, each of the sub-modules comprising at least one bridge arm and a capacitor connected in parallel to the bridge arm, the capacitor having a positive terminal and a negative terminal; and a voltage detection unit for detecting a voltage between at least two adjacent sub-modules in the N sub-modules, the voltage detection unit being connected between the positive terminal of the capacitor of the first sub-module and the negative terminal of the capacitor of the last sub-module in the at least two sub-modules.

Abstract: A touch control panel, a touch control display panel, and a touch control display apparatus are provided. The touch control panel includes multiple first touch control structures extending along a first direction and multiple second touch control structures extending along a second direction. The first touch control structure includes multiple first touch control electrodes and multiple first connecting parts, and the second touch control structure includes multiple second touch control electrodes and multiple second connecting parts. The first touch control electrode and the second touch control electrode are disposed in a same layer, and the first connecting part or the second connecting part is disposed in the same layer as the first touch control electrode. The touch control panel further includes at least one touch control branch positioned at an edge of a touch control electrode.

Abstract: A dual active bridge circuit includes a primary side circuit including first high-side transistor and a first low-side transistor electrically coupled at a first node, and an energy transfer inductor coupled to the first node and configured to provide an inductor current based on a voltage differential across the energy transfer inductor. A secondary side circuit includes a second high-side transistor and a second low-side transistor electrically coupled at a second node. A transformer is configured to transfer energy from the primary side circuit to the secondary side circuit based on the inductor current. A controller is configured to drive each of the transistors between respective switching states with a same duty cycle to control the voltage differential across the energy transfer inductor. The same duty cycle is less than 50% such that all of the transistors are simultaneously off for a predetermined interval.

Abstract: The present disclosure provides a display panel, a method for preparing the same, and a display device. The display panel includes pixel units distributed in an array in a display area, where the pixel units include sub-pixels, at least one of which has a maximum grayscale value voltage different from a maximum grayscale value voltage of the other sub-pixel; and a switching circuit including switching units on a side of the display area, where one end of the switching unit is connected to a data line. In two adjacent columns of pixel units, two sub-pixels having the same maximum grayscale value voltage are connected to two adjacent switching units through data lines, respectively.

Abstract: A method for resource indication and a terminal device are provided. The method includes the following. A terminal device receives downlink control information (DCI) sent by a network device. The DCI is used for scheduling P channels, and the P channels are located on at most N serving cells and/or serving cell groups, where P and N each are a positive integer, and N?P. The DCI includes a resource assignment field, and the resource assignment field indicates resources for the P channels.

Abstract: Provided is a method for transmitting uplink control information. The method comprises: transmitting feedback response information of a first priority, feedback response information of a second priority, and one or more scheduling requests (SRs) of the first priority over a first uplink channel resource, wherein the first priority is higher than the second priority.

Abstract: There is a method comprising determining a beamforming configuration for a time period for reception of uplink data from a user device, determining uplink power control information based on the determined beamforming configuration and providing an indication of the determined uplink power control information to the user device for use in determining uplink transmit power for the time period.

Abstract: Provided herein are compositions comprising circular DNA derived from chromosomal DNA of a eukaryote (eccDNA), as well as methods for producing and administering such compositions for the purpose of simulating an immune response in an individual.