Abstract: Disclosed are cationic lipids which are compounds of Formula (I?). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Abstract: Disclosed herein is a device for detecting nucleic acids, the device comprising a CRISPR-Cas13a-mediated graphene field-effect transistor comprising a source electrode; a drain electrode; a gate electrode; a detection channel; where the channel comprises a CRISPR-Cas13a-mediated graphene layer; where Cas13a is operative to function as an effector protein that targets a specific RNA sequence for cleavage based on a recognition of the RNA sequence by crRNA. Disclosed herein too is a device for detecting nucleic acids, the device comprising a CRISPR-Cas12a-mediated graphene field-effect transistor comprising a source electrode; a drain electrode; a gate electrode; a detection channel; where the channel comprises a CRISPR-Cas12a-mediated graphene layer; where Cas12a is operative to function as an effector protein that targets a specific DNA sequence for cleavage based on a recognition of the DNA sequence by crRNA.

Abstract: Disclosed is a display substrate, including a base substrate (100), a circuit structure layer disposed on the base substrate (100), and a light emitting structure layer. The circuit structure layer includes a plurality of pixel circuits located in a first display region (A1), at least one first trace 231 extending along a first direction (D1), at least one second trace 232 extending along a second direction (D2), and at least one third trace located in a peripheral region (BB). The at least one first trace (231) is electrically connected with the at least one second trace (232) and the at least one third trace is electrically connected with at least one of following; the at least one first trace (231) and the at least one second trace (232).

Abstract: Provided is a display substrate. In the display substrate, a base substrate includes a display region, a bending region and a pad region. A length of the display region in a first direction is greater than a length of the display region in a second direction. Since the pad region, the bending region and the display region are arranged along the second direction, the pad region is arranged on a side where a long boundary line of the display region is located, such that each signal line led into the display region from the pad region has a relatively short length in the display region.

Abstract: A display panel includes: a display substrate, a first barrier wall surrounding a display area, a blocking portion between the first barrier wall and the display area, a first encapsulation layer covering at least the display area, and touch wires. The blocking portion at least partially surrounds the display area. The first encapsulation layer includes a first surface, a second surface and a transition surface connecting the surfaces. On the display substrate, orthographic projections of the touch wires at least partially overlap with an orthographic projection on of the second surface, and are staggered with an orthographic projection of the transition surface; and at least a portion of the orthographic projection of the transition surface is located in a region between a border, away from the display area, of an orthographic projection of the blocking portion and an orthographic projection of a touch wire farthest away from the display area.

Abstract: A system receives one or more transcripts of communications between entities. The system identifies a requested action in the communications based at least in part on a mapping between the requested action and an application programming interface. The system identifies one or more statements eliciting information, based on parameters to the application programming interface. The system generates a definition of an artificial agent based, at least in part, on the requested action and the one more statements eliciting information.

Abstract: Aspects of the disclosure provide an achromatic lens. The achromatic lens can include a first lens and a second lens. The first lens with a negative focal length includes a first optically transparent member having a first surface and a second surface. The second lens is attached to the first lens at the second surface. The second lens having a positive focal length includes a second optically transparent member having a third surface and a fourth surface. A second chromatic aberration of the second lens is reduced by a first chromatic aberration of the first lens. The second surface of the first lens includes a first Fresnel structure.

Abstract: A display substrate and an electronic device are provided. The display substrate includes a base substrate, an insulating layer, and a conductive layer; the conductive layer is on a side of the insulating layer away from the base substrate; the insulating layer includes at least one concave portion; the conductive layer includes a first signal line and a second signal line which are adjacent to each other and arranged side by side; the first signal line and the second signal line are spaced apart and insulated from each other; the first signal line includes a first overlapping portion overlapping with the concave portion in a direction perpendicular to the base substrate; and a distance between the first overlapping portion and the second signal line is greater than or equal to a preset distance being greater than or equal to ½ of a line width of the first overlapping portion.

Abstract: Aspects of the disclosure provide an optical system. The optical system includes a polarization controller that controls polarization states of light beams such that a polarization state of each light beam passing through the polarization controller has one of a first polarization state and a second polarization state. The optical system includes a beam splitter, a reflective polarizer, and one or more lenses between the beam splitter and the reflective polarizer. If a polarization state of a first light beam of the light beams that passes through the polarization controller has the first polarization state, the first light beam passes the one or more lenses only one time. If a polarization state of a second light beam of the light beams that passes through the polarization controller has the second polarization state, the second light beam passes the one or more lenses more than one time.

Abstract: A multi-focus histotripsy method based on a pulsed ultrasound phased array with hundred elements is provided. Excitation amplitude and phase of individual elements are regulated to control a phased array to produce multiple focus modes. A two-stage histotripsy is performed based on these focus modes. In a first stage, a first pulsed ultrasound is applied to an experimental sample in a target area to induce generation of cavitation microbubbles and boiling bubbles to preliminarily homogenize the experimental sample to form a loose product; and in a second stage, the experimental sample is mechanically disrupted and homogenized using a second pulsed ultrasound. The first pulsed ultrasound and the second pulsed ultrasound each are a hundred micro-second pulse or a milli-second pulse. Duty cycles of the first pulsed ultrasound and the second pulsed ultrasound are 3-10% and less than 2%, respectively. A multi-focus histotripsy system is further provided.

Abstract: Aspects of the disclosure provide an optical system that includes a first lens including a first optically transparent member having a first surface and a second surface and a reflective polarizer on the first surface. The first surface of the first lens includes a first region and a second region, the first region of the first surface is smooth and at a center of the first surface, and the second region of the first surface includes a Fresnel structure and surrounds the first region. The reflective polarizer includes a first region and a second region, the first region of the reflective polarizer matches a profile of the first region of the first surface of the first lens, and the second region of the reflective polarizer matches a profile of the second region of the first surface of the first lens.

Abstract: The present disclosure provides a method of perceiving a position and pose of a hydraulic support group based on multi-point ranging and belongs to the field of test or measurement technologies unlisted in other categories. The method uses a hydraulic support group. The hydraulic support group includes multiple juxtaposed hydraulic supports. The method includes: with a plane above a base as a reference plane, establishing a reference coordinate system; perceiving a relative position of the base and a canopy of the hydraulic supports and perceiving a position and pose of a single hydraulic support; when the hydraulic supports have axial offset and roll phenomenon, performing offset amount calculation; based on the perception of the position and pose of single hydraulic supports, performing perception on the position and pose of the hydraulic support group.

Abstract: A display panel and a display device. The touch signal line is in the non-display region, surrounds the display region, is on a side of the light shielding layer close to the display region, and provides touch signals to the display region; the light shielding line is in the non-display region, surrounds the display region, and is at a side of the touch signal line away from the display region; the light shielding line is along the direction from the display region to the non-display region, the orthographic projections of the first part of the light shielding line and the light shielding layer overlaps each other, and the orthographic projection of the second part of the light shielding line is between the edge of the orthographic projection of the light shielding layer close to the display area and the edge of the touch signal line away from the display area.

Abstract: Described herein are example, method, system and apparatus for supporting a substrate in a chamber wherein the substrate comprises a surface, contacting the surface of the substrate with an excited species within the chamber, contacting the surface of the substrate with an etchant species within the chamber and removing organic residue or non-organic residue, or a combination thereof, from the surface of the substrate responsive to executing the above steps.

Abstract: Disclosed are a display substrate and a display device. The display substrate includes a pixel circuit and a scan drive circuit, wherein the pixel circuit includes a write transistor and a scan signal line, the scan signal line is electrically connected with a control electrode of the write transistor, and the scan drive circuit includes a first scan clock signal line and a second scan clock signal line. A signal of the first scan clock signal line is a first clock signal, a signal of the second scan clock signal line is a second clock signal, and both of the first clock signal and the second clock signal are periodic clock signals. A duration of the first clock signal being a low-level signal in one period is different from a duration of the second clock signal being a low-level signal in one period.

Abstract: A display panel includes: a base substrate; a first touch layer including a first touch line; a touch insulation layer provided with a via hole at least partially located in the non-display region; and a second touch layer including a second touch line with different resistance per unit length from the first touch line and at least partially located in the non-display region. Orthographic projections of the second touch line and the first touch line on the base substrate at least partially overlap with each other, the second touch line is connected to the first touch line through the via hole; a part of the first touch line and/or the second touch line connected to the functional structure of the display panel forms a connection part, and the via hole is at least located on a side of the connection part away from the functional structure.

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract: The present invention provides a novel anti-CD73 monoclonal antibody. The antibody has high affinity for human CD73 protein. Both biochemical-level and cell-level experiments show that the antibody is highly effective in inhibiting the enzyme activity of CD73. The in-vivo experiment indicates that the antibody has a significant inhibition effect on tumor cell growth. In particular, the antibody does not have the “hook effect” most prior art antibodies have in connection with inhibition of the enzyme activity of CD73, and is therefore more suitable for clinical use than the prior art antibodies.

Abstract: A display substrate and a display device. A first opening region includes a first opening and a first opening peripheral region surrounding the first opening; a display region surrounds the first opening region the first signal lines extend along the first direction; the second signal lines extend along a second direction; the second signal lines pass through the first opening peripheral region along the second direction, each second signal line includes a longitudinal winding portion in the first opening peripheral region; the longitudinal winding portion partially surrounds the first opening; the longitudinal winding portion closest to the first opening among longitudinal winding portion of the plurality of second signal lines is an edge longitudinal winding portion, and the first floating electrode is in a same layer as the edge longitudinal winding portion and is at a side of the edge longitudinal winding portion close to the first opening.

Abstract: A power tool includes a housing, a motor, a ball sleeve, an oscillating member with a mounting portion, and an output shaft rotating around an output shaft axis. The oscillating member and the ball sleeve are engaged in an engagement region on the oscillating member, and the geometric center of the engagement region is an engagement center. A first plane bisects the first bearing assembly along a direction of the output shaft axis, and a second plane bisects the second bearing assembly along the direction of the output shaft axis. The height from the engagement center to the first plane is a first height H1, the height from the engagement center to the second plane is a second height H2, and the ratio H1/H2 of the first height H1 to the second height H2 is greater than or equal to 0.5 and less than or equal to 1.4.