Patents by Inventor Yibin Cai

Yibin Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • siRNA/Nanoparticle Formulations for Treatment of Middle-East Respiratory Syndrome Coronaviral Infection
    Publication number: 20220145301
    Abstract: The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoA) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.
    Type: Application
    Filed: July 12, 2021
    Publication date: May 12, 2022
    Inventors: Patrick Y. LU, Vera SIMONENKO, Yibin CAI, John XU, David EVANS
  • RECOMBINANT INFLUENZA VIRUSES AND CONSTRUCTS AND USES THEREOF
    Publication number: 20220119839
    Abstract: Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.
    Type: Application
    Filed: May 28, 2021
    Publication date: April 21, 2022
    Inventors: Daniel R. Perez, Hongjun Chen, Yibin Cai, Lindomar Jose Pena, Matthew Angel
  • Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection
    Patent number: 11058779
    Abstract: The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: July 13, 2021
    Assignee: Sirnaomics, Inc.
    Inventors: Patrick Y. Lu, Vera Simonenko, Yibin Cai, John Xu, David Evans
  • Recombinant influenza viruses and constructs and uses thereof
    Patent number: 11028408
    Abstract: Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: June 8, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Daniel R. Perez, Hongjun Chen, Yibin Cai, Lindomar Jose Pena, Matthew Angel
  • sirna/Nanoparticle Formulations for Treatment of Middle-East Respiratory Syndrome Coronaviral Infection
    Publication number: 20190030187
    Abstract: The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.
    Type: Application
    Filed: September 7, 2016
    Publication date: January 31, 2019
    Applicant: Sirnaomics, Inc.
    Inventors: Patrick Y. Lu, Vera Simonenko, Yibin Cai, John Xu, David Evans
  • Compositions Comprising Small Interfering RNA Molecules for Prevention and Treatment of Ebola Virus Disease
    Publication number: 20170233742
    Abstract: Disclosed herein are small interfering RNA (siRNA) molecules and pharmaceutical compositions containing them for the prevention and treatment of Ebola virus disease. The present invention provides siRNA molecules that inhibit Ebola virus gene expression, compositions containing the molecules, and methods of using the molecules and compositions to prevent or treat EVD in a subject, such as a human patient.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 17, 2017
    Applicant: Sirnaomics, Inc.
    Inventors: Yibin Cai, Patrick Y. Lu, John J. Xu
  • RECOMBINANT INFLUENZA VIRUSES AND CONSTRUCTS AND USES THEREOF
    Publication number: 20140161771
    Abstract: Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.
    Type: Application
    Filed: May 28, 2013
    Publication date: June 12, 2014
    Inventors: Daniel R. Perez, Hongjun Chen, Yibin Cai, Lindomar Jose Pena, Matthew Angel