Patents by Inventor Yijun Deng

Yijun Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IAP inhibitors
    Patent number: 8415486
    Abstract: The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: April 9, 2013
    Assignee: TetraLogic Pharmaceuticals Corp.
    Inventors: Stephen M. Condon, Yijun Deng, Matthew D. Alexander, Matthew G. Laporte
  • SMAC Mimetic
    Publication number: 20130012564
    Abstract: A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 10, 2013
    Applicant: TETRALOGIC PHARMACEUTICALS CORP.
    Inventors: Stephen M. CONDON, Yijun DENG, Matthew G. LaPorte, Susan R. Rippin
  • 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
    Patent number: 8283372
    Abstract: A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
    Type: Grant
    Filed: June 20, 2010
    Date of Patent: October 9, 2012
    Assignee: TetraLogic Pharmaceuticals Corp.
    Inventors: Stephen M. Condon, Yijun Deng, Matthew G. Laporte, Susan R. Rippin
  • IAP Inhibitors
    Publication number: 20120157390
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Application
    Filed: February 29, 2012
    Publication date: June 21, 2012
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. CONDON, Matthew G. LaPORTE, Yijun DENG, Susan R. RIPPIN
  • IAP INHIBITORS
    Publication number: 20120135990
    Abstract: The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
    Type: Application
    Filed: May 27, 2010
    Publication date: May 31, 2012
    Applicant: TETRALOGIC PHARMACEUTICALS CORP.
    Inventors: Stephen M. Condon, Yijun Deng, Matthew D. Alexander, Matthew G. Laporte
  • SMAC MIMETEC
    Publication number: 20120115922
    Abstract: A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
    Type: Application
    Filed: June 25, 2010
    Publication date: May 10, 2012
    Inventors: Stephen M. Condon, Yijun Deng, Matthew G. Laporte, Susan R. Rippin
  • IAP INHIBITORS
    Publication number: 20120094917
    Abstract: The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
    Type: Application
    Filed: May 25, 2010
    Publication date: April 19, 2012
    Applicant: TETRALOGIC PHARMACEUTICALS CORP
    Inventors: Stephen M. Condon, Yijun Deng, Matthew D. Alexander, Matthew G. Laporte
  • IAP inhibitors
    Patent number: 8143426
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: March 27, 2012
    Assignee: TetraLogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • DIMERIC IAP ANTAGONISTS
    Publication number: 20110305777
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Application
    Filed: June 9, 2011
    Publication date: December 15, 2011
    Applicant: Tetralogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • DIMERIC IAP INHIBITORS
    Publication number: 20110301151
    Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes.
    Type: Application
    Filed: August 2, 2011
    Publication date: December 8, 2011
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP BINDING COMPOUNDS
    Publication number: 20110294827
    Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 1, 2011
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP INHIBITORS
    Publication number: 20110288116
    Abstract: The present invention describes compounds of the following formula: processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. The compounds of the present invention inhibit IAPs (inhibitors of apoptosis proteins) and thus are useful in the treatment of cancer, autoimmune diseases and other disorders where a defect in apoptosis is implicated.
    Type: Application
    Filed: January 15, 2009
    Publication date: November 24, 2011
    Applicant: TETRALOGIC PHARMACEUITCAL CORPORATION
    Inventors: Stephen M. Condon, Matthew G. Laporte, Yijun Deng, Susan Rippin, Yu-Hua Lee, Thomas Haimowitz
  • Dimeric IAP inhibitors
    Patent number: 8022230
    Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: September 20, 2011
    Assignee: TetraLogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • Dimeric IAP inhibitors
    Patent number: 7985735
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: July 26, 2011
    Assignee: Tetralogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP binding compounds
    Patent number: 7968590
    Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: June 28, 2011
    Assignee: Tetralogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • SMAC Mimetic
    Publication number: 20110003877
    Abstract: A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
    Type: Application
    Filed: June 20, 2010
    Publication date: January 6, 2011
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. Condon, Yijun Deng, Matthew G. LaPorte, Susan R. Rippin
  • DIMERIC IAP INHIBITORS
    Publication number: 20100075911
    Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes.
    Type: Application
    Filed: March 13, 2009
    Publication date: March 25, 2010
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. CONDON, Matthew G. LaPORTE, Yijun DENG, Susan R. RIPPIN
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Patent number: 7666863
    Abstract: The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: February 23, 2010
    Assignees: ViroPharma Incorporated, WYETH
    Inventors: Ashis K. Saha, Christopher J Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES
    Publication number: 20090281336
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Application
    Filed: July 9, 2009
    Publication date: November 12, 2009
    Inventors: Ashis K. Saha, Christopher J. Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • Sulfonyl Semicarbazides, Semicarbazides and Ureas, Pharmaceutical Compositions Thereof, and Methods for Treating Hemorrhagic Fever Viruses, Including Infections Associated with Arena Viruses
    Publication number: 20090203675
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
    Type: Application
    Filed: December 6, 2005
    Publication date: August 13, 2009
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Yijun Deng, Theodore J. Nitz, Thomas R. Bailey, Yuanming Zhang, Sylvie Laquerre