Patents by Inventor Yijun Deng

Yijun Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimeric IAP inhibitors
    Patent number: 7517906
    Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: April 14, 2009
    Assignee: TetraLogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP BINDING COMPOUNDS
    Publication number: 20090048183
    Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
    Type: Application
    Filed: October 9, 2008
    Publication date: February 19, 2009
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP binding compounds
    Patent number: 7456209
    Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 25, 2008
    Assignee: Tetralogic Pharmaceuticals Corporation
    Inventors: Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin
  • IAP INHIBITORS
    Publication number: 20080021066
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Application
    Filed: July 24, 2007
    Publication date: January 24, 2008
    Inventors: Stephen Condon, Matthew LaPorte, Yijun Deng, Susan Rippin
  • DIMERIC IAP INHIBITORS
    Publication number: 20080020986
    Abstract: Smac mimetics that inhibit IAPs.
    Type: Application
    Filed: July 24, 2007
    Publication date: January 24, 2008
    Inventors: Stephen Condon, Matthew LaPorte, Yijun Deng, Susan Rippin
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Patent number: 7265152
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: September 4, 2007
    Assignees: ViroPharma Incorporated, Wyeth
    Inventors: Ashis K. Saha, Christopher J Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • Dimeric IAP inhibitors
    Publication number: 20060194741
    Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of LAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes.
    Type: Application
    Filed: February 27, 2006
    Publication date: August 31, 2006
    Inventors: Stephen Condon, Matthew LaPorte, Yijun Deng, Susan Rippin
  • IAP binding compounds
    Publication number: 20060025347
    Abstract: IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kd of less that 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposes are also disclosed.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 2, 2006
    Inventors: Stephen Condon, Matthew LaPorte, Yijun Deng, Susan Rippin
  • Method for synthesis of substituted azole libraries
    Patent number: 6951948
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components are as described herein, novel intermediates useful for synthesizing such substituted azole compounds and methods for identifying and isolating the compounds.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: October 4, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Yijun Deng, Dennis Hlasta
  • Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
    Publication number: 20040162318
    Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
    Type: Application
    Filed: October 31, 2003
    Publication date: August 19, 2004
    Inventors: Ashis K. Saha, Christopher J. Burns, Alfred M. Del Vecchio, Thomas R. Bailey, Jason A. Reinhardt, Bheemashankar A. Kulkarni, Thomas H. Faitg, Hao Feng, Susan R. Rippin, Charles W. Blackledge, David J. Rys, Thomas A. Lessen, John Swestock, Yijun Deng, Theodore J. Nitz
  • Method for synthesis of substituted azole libraries
    Patent number: 6683191
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components are as described herein, novel intermediates useful for synthesizing such substituted azole compounds and methods for identifying and isolating the compounds.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: January 27, 2004
    Assignee: Ortho-McNeil Pharmaceuticals, Inc.
    Inventors: Yijun Deng, Dennis Hlasta
  • Method for synthesis of substituted azole libraries
    Publication number: 20020077483
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) 1
    Type: Application
    Filed: May 22, 2001
    Publication date: June 20, 2002
    Inventors: Yijun Deng, Dennis Hlasta
  • Method for synthesis of substituted azole libraries
    Publication number: 20020042520
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) 1
    Type: Application
    Filed: May 22, 2001
    Publication date: April 11, 2002
    Inventors: Yijun Deng, Dennis Hlasta