Patents by Inventor Yimin Hua

Yimin Hua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240238326
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: October 25, 2023
    Publication date: July 18, 2024
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: C. Frank Bennett, Gene Hung, Frank Rigo, Adrian R. Krainer, Yimin Hua, Marco A. Passini, Lamya Shihabuddin, Seng H. Cheng, Katherine W. Klinger
  • Publication number: 20220325280
    Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.
    Type: Application
    Filed: April 18, 2022
    Publication date: October 13, 2022
    Inventor: Yimin HUA
  • Patent number: 11312959
    Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: April 26, 2022
    Assignee: ASOcura Pharmaceuticals Suzhou Co., Ltd.
    Inventor: Yimin Hua
  • Publication number: 20210246449
    Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.
    Type: Application
    Filed: February 11, 2021
    Publication date: August 12, 2021
    Applicant: ACCUTAR BIOTECHNOLOGY INC.
    Inventor: Yimin HUA
  • Publication number: 20200376018
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: December 10, 2019
    Publication date: December 3, 2020
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: C. Frank Bennett, Gene Hung, Frank Rigo, Adrian R. Krainer, Yimin Hua, Marco A. Passini, Lamya Shihabuddin, Seng H. Cheng, Katherine W. Klinger
  • Patent number: 10852398
    Abstract: A movable system includes a movable platform that includes a motorized drive to cause the movable platform to move in position, and a compartment located in an interior part of the movable platform; and an LIDAR system mounted to the movable platform including a probe fiber laser module located on the movable platform and producing pulsed probe laser light and scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area based on detection of reflected probe laser light from the one or more objects. The probe fiber laser module includes a base laser module located inside the enclosure of the compartment and remote laser modules distributed at the platform instrument holding portions to scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area.
    Type: Grant
    Filed: November 17, 2019
    Date of Patent: December 1, 2020
    Assignee: O-NET COMMUNICATIONS (SHENZHEN) LIMITED
    Inventors: Aihua Yu, Yimin Hua
  • Publication number: 20200341124
    Abstract: A movable system includes a movable platform that includes a motorized drive to cause the movable platform to move in position, and a compartment located in an interior part of the movable platform; and an LIDAR system mounted to the movable platform including a probe fiber laser module located on the movable platform and producing pulsed probe laser light and scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area based on detection of reflected probe laser light from the one or more objects. The probe fiber laser module includes a base laser module located inside the enclosure of the compartment and remote laser modules distributed at the platform instrument holding portions to scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area.
    Type: Application
    Filed: November 17, 2019
    Publication date: October 29, 2020
    Inventors: Aihua Yu, Yimin Hua
  • Publication number: 20200181613
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: July 10, 2019
    Publication date: June 11, 2020
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: Brenda F. Baker, Adrian R. Krainer, Yimin Hua
  • Publication number: 20200006911
    Abstract: The present disclosure provides a doped fiber amplifier and a working method thereof. The doped fiber amplifier including a seed source inputting signal light, a first isolator connected with the seed source, a coupler connected with the first isolator, a pump laser and a doped fiber connected with the coupler, a second isolator connected with the doped fiber, an optical splitter connected with the second isolator, and a connection head connected with the optical splitter. The connection head outputs a signal light of the seed source.
    Type: Application
    Filed: August 12, 2019
    Publication date: January 2, 2020
    Inventors: Kaiyuan Lu, Yimin Hua
  • Publication number: 20190384001
    Abstract: The present disclosure provides an array-type light source light-splitting device and a light splitting method thereof. The array-type light source light-splitting device includes a seed source inputting signal light, an optical fiber amplifier connected with the seed source, and a light splitter connected with the optical fiber amplifier. The light splitter includes N paths of optical fibers. N is a natural number. The light splitter splits the signal light of the seed source into N paths and outputs them. The light splitter splits the signal light of the seed source into multi-path signal light and outputs them, meanwhile the power is amplified by the optical fiber amplifier of each path to become the multi-path signal light and outputs them. A repetition rate of the 1550 nm laser is able to reach megahertz.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 19, 2019
    Inventors: KAIYUAN LU, YIMIN HUA
  • Publication number: 20190211330
    Abstract: Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: November 1, 2018
    Publication date: July 11, 2019
    Applicants: Ionis Pharmaceuticals, Inc., Cold Spring Harbor Laboratory
    Inventors: Yimin Hua, Adrian R. Krainer, Frank Rigo, C. Frank Bennett
  • Patent number: 10281650
    Abstract: An optical comb filter, comprising an input/output collimator (50), an output collimator (60), a spectroscope (10), and first, second and third GT resonant cavities (20, 30, 40), wherein each GT resonant cavity comprises a transparent solid block coated with a membrane layer and a spacing part, a through hole is provided on the transparent solid block, and the transparent solid block and the spacing part form a hollow cavity; and rectangular orientation of an insertion loss curve is realized, and the bandwidth utilization rate is high.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: May 7, 2019
    Assignee: O-NET COMMUNICATIONS (SHENZHEN) LIMITED
    Inventors: Shuliang Huang, Yimin Hua, Liancheng Li
  • Publication number: 20190030058
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: February 9, 2018
    Publication date: January 31, 2019
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: C. Frank Bennett, Gene Hung, Frank Rigo, Adrian R. Krainer, Yimin Hua, Marco A. Passini, Lamya Shihabuddin, Seng H. Cheng, Katherine W. Klinger
  • Publication number: 20180291376
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: November 20, 2017
    Publication date: October 11, 2018
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: Brenda F. Baker, Adrian R. Krainer, Yimin Hua
  • Patent number: 9874698
    Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: January 23, 2018
    Assignee: Lumentum Operations LLC
    Inventors: Barthelemy Fondeur, Jinxi Shen, Leonid Frenkel, Yimin Hua, David R. Walker, Yu Zhang, Vlatko Milinkovic
  • Patent number: 9758542
    Abstract: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: September 12, 2017
    Assignee: Purdue Research Foundation
    Inventors: Mary J. Wirth, Yimin Hua, Zhaorui Zhang
  • Patent number: 9717750
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: August 1, 2017
    Assignees: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: C. Frank Bennett, Gene Hung, Frank Rigo, Adrian R. Krainer, Yimin Hua, Marco A. Passini, Lamya Shihabuddin, Seng H. Cheng, Katherine W. Klinger
  • Publication number: 20170168241
    Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.
    Type: Application
    Filed: May 11, 2016
    Publication date: June 15, 2017
    Inventors: Barthelemy FONDEUR, Jinxi SHEN, Leonid FRENKEL, Yimin HUA, David R. WALKER, Yu ZHANG, Vlatko MILINKOVIC
  • Publication number: 20170088835
    Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 30, 2017
    Applicants: Biogen MA Inc., Cold Spring Harbor Laboratory
    Inventors: Brenda F. Baker, Adrian R. Krainer, Yimin Hua
  • Patent number: 9595430
    Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 14, 2017
    Assignees: LI-COR, INC., Purdue Research Foundation
    Inventors: Michael D. Furtaw, Jon P. Anderson, Mary J. Wirth, Robert E. Birdsall, Yimin Hua, Zhaorui Zhang