Abstract: In an illustrative embodiment, methods and systems for modeling health care affordability across a population includes segmenting the population by demography and/or geography, determining chronic condition distribution across the population segments, modeling, across the population segments, medical service utilization distribution for a set of medical services, and calculating, using unit costs for each of the set of medical services, utilization costs for each population segment. The methods and systems may include calculating relative affordability metrics based on the utilization costs.

Abstract: Provided herein are tetravalent antibodies that specifically bind to human PSGL-1. Unlike bivalent antibodies, these tetravalent antibodies contain a dimer of two monomers, with each monomer comprising two light chain variable (VL) domains and two heavy chain variable (VH) domains. This format allows for cross-linker/FcR-expressing cell-independent tetravalent antibodies against PSGL-1 that show enhanced efficacy as compared to bivalent PSGL-1 antibodies. These tetravalent antibodies can be used in a variety of diagnostic and therapeutic methods, including without limitation treating T-cell mediated inflammatory diseases, transplantations, and transfusions.

Abstract: A display substrate, including a plurality of gate lines and a plurality of data lines defining a plurality of pixel regions, where the plurality of pixel regions include a plurality of normal pixel regions and a plurality of redundant pixel regions at a periphery of the normal pixel regions; where each normal pixel region is provided with a first pixel electrode and a first transistor, each redundant pixel region is provided with a second pixel electrode and a second transistor, a gate of the first transistor is connected to a corresponding gate line, a source of the first transistor is connected to a corresponding data line, and a drain of the first transistor is connected to the first pixel electrode; and the second pixel electrode and the second transistor are insulated and spaced apart from each other.

Abstract: In a method for inspecting pattern defects, a plurality of patterns are formed over an underlying layer. The plurality of patterns are electrically isolated from each other. A part of the plurality of patterns are scanned with an electron beam to charge the plurality of patterns. An intensity of secondary electrons emitted from the scanned part of the plurality of patterns is obtained. One or more of the plurality of patterns that show an intensity of the secondary electrons different from others of the plurality of patterns are searched.

Abstract: An autonomous pathogen detection and disinfection mobile platform having a small footprint, such that embodiments of the platform are deployable within interior spaces such as hospital, clinics, and other healthcare facilities. The platform includes a detection chamber that efficiently identifies a presence of a pathogen, such as a microorganism. The platform also includes a disinfection discharge component, such as a discharge needle, that treats a surface that includes a presence of a pathogen. As an autonomous mobile device, the platform includes sensors, cameras, or similar devices to detect surrounding surfaces, such that a computing device disposed on the platform plots a dynamic path for the platform based on received feedback.

Abstract: The present application relates to an EPA-EE nano-lipid composition and a formulation, a preparation method, and an application thereof. The EPA-EE nano-lipid composition includes a raw material having a high content of EPA-EE as a primary ingredient and includes an emulsifier containing a highly unsaturated phospholipid. The EPA-EE nano-lipid composition can be prepared into a sub-micron emulsion at nanoscale for use as an oral formulation.

Abstract: The present disclosure provides a method of manufacturing a semiconductor device. The method includes: providing a substrate having an array area and a periphery area; forming an etch stop layer on a top surface of the substrate in the array area and the periphery area; forming a patterned mask layer on a top surface of the etch stop layer in the array area and the periphery area, in which the patterned mask layer has a plurality of hollowed portions; forming a plurality of trenches on the top surface of the etch stop layer in the array area and the periphery area through the hollowed portions of the patterned mask layer, in which the trenches run through the etch stop layer and are recessed from the top surface of the substrate; removing the patterned mask layer; and depositing an oxide layer to fill the trenches.

Abstract: An immunity detecting kit includes an immune-stimulant agent and a Chinese herb combination or a nutrient combination. The immune-stimulant agent includes a phorbol 12-myristate 13-acetate (PMA) and a lipopolysaccharide (LPS). The Chinese herb combination includes at least one Chinese herb extract. The nutrient combination includes at least one nutritional product. A using method of immunity detecting kit is also provided.

Abstract: An electronic device is disclosed. The electronic component has a front side and a backside opposite to the front side. The front side is configured to receive a first power. The backside is configured to receive a second power greater than the first power.

Abstract: The present invention relates to crosslinkable ink compositions and the preparation and use thereof.

Abstract: A heat transfer device for applying a varying temperature to a portion of an animate body comprises a liquid conduit. The liquid conduit is liquidly connectable to an external first liquid source to establish a first circulation loop for transporting a first liquid. The liquid conduit is liquidly connectable to an external second liquid source to establish a second circulation loop for transporting a second liquid. The second liquid has a higher temperature than the first liquid. The liquid conduit is operably switchable between the first circulation loop and the second circulation loop for achieving the varying temperature applied to the portion of the animate body.

Abstract: Provided is an inspection tool for a touch panel, including a substrate adapted to be placed on the touch panel and multiple protrusions disposed on the substrate in correspondence to multiple touch inspection points and arranged along an inspection trajectory. An inspection method for a touch panel is also provided.

Abstract: A method is disclosed performed by a network node of a communications network, for improving communication by a wireless device, WD. The method comprises transmitting, to the WD, a message indicating that a change of an interference state in the communications network will occur.

Abstract: The invention relates to distributed ledge technologies such as consensus-based blockchains. Computer-implemented methods for a secure random number generation within blockchain scripts are described. The invention is implemented using a blockchain network, which may be, for example, a Bitcoin blockchain. A third transaction is validated. The third transaction is associated with a third digital asset and includes a first and second puzzle in a locking script. The first puzzle is included, in a first transaction, in a first locking script that encumbers transfer of control of a first digital. The second puzzle is included, in a second transaction, in a second locking script that encumbers transfer of control of a second digital asset. A pseudorandom number is generated based at least in part on solutions to the first and second puzzles. Control of the third digital asset is transferred based at least in part on the pseudorandom number.

Abstract: The present discussion relates to the delivery of ultrasonic therapy energy to a target region in conjunction with a clear path determination that may assess one or more of: (1) presence of non-soft tissue regions within the therapy beam path (e.g., bone or bone-like structures, gas-filled cavities, and so forth), (2) partial “lift-off” of the probe head; or (3) sufficiency of acoustic coupling. Upon determination or confirmation of at least a partial clear path with respect to some or all of these factors, the therapy beam may be delivered to the target region.

Abstract: Disclosed is a method for purifying a graphite material, which includes the following steps of: after placing the graphite material in a graphite crucible, placing the graphite crucible into a heating furnace; after vacuuming the heating furnace, filling the heating furnace with a protective atmosphere, and controlling a pressure in the heating furnace to be less than 5 Torr; and heating the graphite crucible, by a heater disposed in the heating furnace, to control a temperature of the graphite crucible to be at least higher than melting point temperatures of some metal impurities in the graphite material for a preset time period, so that the some metal impurities in the graphite material are volatilized or carbonized, and the graphite crucible is purified. Therefore, while the graphite material is purified under a condition with high vacuum, high temperature and low pressure, the graphite crucible is also purified.

Abstract: The present invention provides a conjugate comprising: (a) a CNS-targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), or dextran, and (c) a flavonoid. The present invention also provides to a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, optionally (b) an inner shell comprising oligomeric (?)-epigallocatechin gallate (OEGCG), and optionally (c) a CNS disease-treating molecule encapsulated in the inner shell. The present invention further provides a method for treating a CNS disease by administering an effective amount of the present nanoparticle composition to a subject. The CNS-targeting ligand targets the CNS tissue and delivers active ingredients to CNS tissue for treating the CNS pathogenic conditions.

Abstract: Disclosed is a device for preparing a silicon carbide crystal including a crucible and a crystal expansion guide assembly. The crucible includes a crucible body and a crucible cover fixing a seed and covering the crucible body. The crystal expansion guide assembly includes a frame member and a tubular core member. The frame member is fixed to the crucible body, located between the crucible cover and a raw material accommodated in the crucible body, and provided with a through hole with a diameter greater than a diameter of a growth surface of the seed. The tubular core member is mechanically connected to an inner wall of the through hole. During a crystal growth process, the tubular core member falls off due to contact with a growth front of a crystal. The frame member does not react with the crystal. Thus, a large-sized crystal ingot with high quality can be obtained.

Abstract: Disclosed is a silicon carbide crystal growth system including a crucible, a heating device and a seed holder. The crucible includes a crucible body and a crucible cover covering the crucible body. The heating device includes a quartz tube and an induction coil spirally wound on an outer wall of the quartz tube. The crucible is disposed in the quartz tube. The crucible is disposed coaxially with the quartz tube. The seed holder is disposed on the crucible cover and includes a seed holding surface for holding an off-axis seed and is perpendicular to a central axis of the crucible, and an angle between a normal direction of the induction coil and a growth direction of the off-axis seed is between 0 degrees and 10 degrees, so that a silicon carbide crystal grows from the off-axis seed along isotherms provided by the induction coil, thereby obtaining a silicon carbide boule.

Abstract: A system is provided for carbon dioxide (CO2) emission recovery. The system includes a methanization reactor. The methanization reactor is configured to receive CO2 separated from one or more off gases of a brake manufacturing process, convert the CO2 and supplied hydrogen (H2) via methanization to produce methane (CH4); and supply the produced CH4 to at least one of a carbon/carbon (C/C) preform production process or another system for heat generation.