Abstract: A molding device and a molding method for an optical fiber preform are provided. The molding device includes a rotating mechanism, an extrusion mechanism, and a cylinder mold that is of a cylindrical structure with two ends each having an opening. After a hollow cladding sleeve is obtained by rotating the cylinder mold through the rotating mechanism, a molten core glass is then reversely extruded into the cladding sleeve in the cylinder mold from bottom to top by the extrusion mechanism to prepare the optical fiber preform.

Abstract: An ear canal clamp for small animals includes a base and a clamping mechanism. The clamping mechanism includes two clamping arms movably mounted on the base, a biasing member mounted on the base and constrained between the clamping arms, and two ear canal positioning members mounted respectively to the clamping arms and facing each other. The clamping arms are configured to move toward each other and compress the biasing member to increase the distance between the ear canal positioning members. A biasing force generated by the biasing member when compressed is used to push the clamping arms to move oppositely with respect to each other.

Abstract: Provided is an organic electroluminescent device and an application thereof. The organic electroluminescent device includes a metal complex having a substituent A capable of reducing a maximum capacitance in the device, and the metal complex can be used as an emissive material in an emissive layer of the electroluminescent device. The device including a metal complex having the substituent A can obtain a decrease in the maximum capacitance of the device, thereby improving the response time and refresh frequency of an OLED display device at a low grayscale. In another aspect, the substituent A can cause a decrease in the maximum capacitance of the device, and the device prepared with the metal complex including the substituent A can still maintain excellent device performance compared with the devices prepared with the metal complexes that do not include the substituent A. Further provided is an electronic assembly including the organic electroluminescent device.

Abstract: The present invention provides a high-strength and high-heat-resistant bio-based polyamide composition, which consists of the following parts of materials by mass: 43.50-89.95% of bio-based polyamide resin slices; 10-50% of reinforcements; 0.01-2% of rare earth compounds; 0.01-1% of copper salt antioxidant combinations; 0.01-1% of free-radical scavengers; 0.01-0.5% of heat-conducting masterbatches; 0.01-1% of stabilizers; and 0-1% of dispersants. The advantage of the present invention is presented in that: the bio-based polyamide resin slice is prepared through a stepwise polycondensation process of pentanediamine and adipic acid, or through a stepwise polycondensation process of pentanediamine, adipic acid and terephthalic acid and the pentanediamine is prepared through fermentation of starch, so the prepared polyamide resin pertains to an environmentally-friendly engineering plastic.

Abstract: Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen binding fragment thereof; (b) an anti-human LAG3 monoclonal antibody or antigen binding fragment thereof; and (c) an anti-human TIGIT monoclonal antibody or antigen binding fragment thereof. Also provided are pharmaceutical compositions and kits containing such agents for the treatment of cancer or infection.

Abstract: An intelligent tool holder includes a tool-holder main body and a sensing reading device. The tool-holder main body includes a connecting portion which is provided with a plurality of embedded holes respectively embedded with a sensing element therein to kinetically detect sensed data including stress and strain of the tool-holder main body which are correspondingly formed as being loaded from the processing tool. The sensing reading device includes a housing to outwardly cover the connecting portion of the tool-holder main body. A sensing reading module is provided to read the sensed data of the sensing element transmitted therefrom. An active sensing method having a particular rotational angle is provided, thereby increasing sensing properties, lowering the coupling effects and detecting a global forced condition in a processing procedure.

Abstract: This disclosure, in general, relates to nonwoven abrasive belts including flexible butt joints and methods of making and using such belts and joints.

Abstract: The present disclosure discloses a monitoring device for internal deformation and fine particle loss of a railway subgrade, relating to the field of monitoring devices. The monitoring device includes an internal damage monitoring device arranged in a subgrade ballast layer. The internal damage monitoring device is connected to a resistance acquisition instrument through a wire. The resistance acquisition instrument is in wireless connection with a resistance signal receiver. The monitoring device for internal deformation and fine particle loss of a railway subgrade provided by the present disclosure can remotely realize real-time continuous monitoring of the deformation and fine particle loss inside the railway subgrade under a rail transit load, is economical and convenient, and has high practice value.

Abstract: Large scale processes for producing high purity samples of biologically active molecules of interest from bacterial cells are disclosed. The methods comprise the steps of producing a lysate solution by contacting a cell suspension of said plurality of cells with lysis solution; neutralizing said lysate solution with a neutralizing solution to produce a dispersion that comprises neutralized lysate solution and debris; filtering the dispersion through at least one filter; performing ion exchange separation on said neutralized lysate solution to produce an ion exchange eluate; and performing hydrophobic interaction separation on said ion exchange eluate to produce a hydrophobic interaction solution. Further, provided are compositions comprising large scale amounts of plasmid DNA produced by the disclosed large scale processes.

Abstract: Articles and methods regarding the making and use of low-shedding nonwoven abrasive articles, such as abrasive wheels and hand pads, that have a low shed rate and achieve a high grind ratio. The abrasive articles comprise a blend of a plurality of primary abrasive particles and a plurality of reinforcing abrasive particles that is disposed on a nonwoven web substrate. The primary abrasive particles have an average particle size equal to or larger than the average fiber diameter of the substrate fibers, and the reinforcing abrasive particles have an average particle size smaller than the average fiber diameter.

Abstract: Provided herein are methods and systems for inferring biological age in a subject. The methods involve analyzing data from a microbiome and/or somatic cell transcriptome from a subject and executing a model that infers biological age.

Abstract: Large scale processes for producing high purity samples of biologically active molecules of interest from bacterial cells are disclosed. The methods comprise the steps of producing a lysate solution by contacting a cell suspension of said plurality of cells with lysis solution; neutralizing said lysate solution with a neutralizing solution to produce a dispersion that comprises neutralized lysate solution and debris; filtering the dispersion through at least one filter; performing ion exchange separation on said neutralized lysate solution to produce an ion exchange eluate; and performing hydrophobic interaction separation on said ion exchange eluate to produce a hydrophobic interaction solution. Further, provided are compositions comprising large scale amounts of plasmid DNA produced by the disclosed large scale processes.

Abstract: The present disclosure relates to abrasive buffing articles (“abrasive buffs”) and methods of making the same. The abrasive buffs include a substrate, such as a fabric, that has been impregnated with an abrasive polymeric composition that includes abrasive particles, such as primary abrasive particles and/or abrasive aggregates, such as spray dried abrasive aggregates. The abrasive buffs are flexible and capable of conforming to and effectively abrading, polishing, and buffing workpieces possessing a complex geometry.

Abstract: The present disclosure discloses a monitoring device for internal deformation and fine particle loss of a railway subgrade, relating to the field of monitoring devices. The monitoring device includes an internal damage monitoring device arranged in a subgrade ballast layer. The internal damage monitoring device is connected to a resistance acquisition instrument through a wire. The resistance acquisition instrument is in wireless connection with a resistance signal receiver. The monitoring device for internal deformation and fine particle loss of a railway subgrade provided by the present disclosure can remotely realize real-time continuous monitoring of the deformation and fine particle loss inside the railway subgrade under a rail transit load, is economical and convenient, and has high practice value.

Abstract: According to some embodiments in this application, a method for making a JFET device is disclosed in the following steps: forming a substrate; performing ion implantation on the first region and the second region of the substrate to form a deep N-type well, wherein the deep N-type well is formed with at least two sub-wells region; forming a field oxide in the second region; forming a P-type well in one side of the sub-well in the deep N-type well; performing P-type ion implantation on the third region and the fourth region to respectively form a first P-type heavily doped region and a second P-type heavily doped region; and performing N-type ion implantation on the fifth region, the sixth region, and the seventh region to respectively form a first N-type heavily doped region, a second N-type heavily doped region, and a third N-type heavily doped region.

Abstract: According to some embodiments in this application, a method for making a JFET device is disclosed in the following steps: forming a substrate; performing ion implantation on the first region and the second region of the substrate to form a deep N-type well, wherein the deep N-type well is formed with at least two sub-wells region; forming a field oxide in the second region; forming a P-type well in one side of the sub-well in the deep N-type well; performing P-type ion implantation on the third region and the fourth region to respectively form a first P-type heavily doped region and a second P-type heavily doped region; and performing N-type ion implantation on the fifth region, the sixth region, and the seventh region to respectively form a first N-type heavily doped region, a second N-type heavily doped region, and a third N-type heavily doped region.

Abstract: The invention belongs to the technical field of medicines. In particular, the invention relates to use of (benzenesulfonamido) benzamide compounds for inhibiting liver fibrosis, or preventing and/or treating a liver injury, or improving a liver function, or preventing and/or treating a liver disease associated with liver fibrosis, for modulating (e.g. reducing) the content of collagen (e.g. type I collagen) in liver tissue, for modulating (e.g. inhibiting) the activity of COL1A1 promoter in a cell, and for modulating (e.g. inhibiting) expression level of a gene associated with liver fibrosis in a cell.

Abstract: Disclosed herein are systems and techniques for adaptive capacitor charge voltage management, particularly for lithium-ion capacitors and hybrid capacitors. The techniques adapt the capacitor charge voltage and hence the capacitor stored energy based on capacitor operating temperature and one or more of the capacitance and the equivalent series resistance (ESR) of the capacitor.

Abstract: Disclosed herein are systems and techniques for adaptive capacitor charge voltage management, particularly for lithium-ion capacitors and hybrid capacitors. The techniques adapt the capacitor charge voltage and hence the capacitor stored energy based on capacitor operating temperature and one or more of the capacitance and the equivalent series resistance (ESR) of the capacitor.

Abstract: This disclosure, in general, relates to nonwoven abrasive belts including flexible butt joints and methods of making and using such belts and joints.