Abstract: Systems and methods for concurrent processing and inspection of semiconductor devices are provided. Disclosed systems include multi-layered holders for supporting processes semiconductor devices and materials, which are hollow and configured in a way that enables coaxially aligning the processing head and the inspection head and positioning and maintaining the semiconductor device and materials at a plane perpendicular to the alignment axis during processing and inspection thereof. Disclosed configurations provide real-time feedback to ensure positional accuracy of the processing head, the semiconductor device and materials during the processing thereof. The multi-layer and multi-functional platform for semiconductor processing provides a system designed to work in synergy to facilitate precise semiconductor processing, real-time inspection, and alignment.

Abstract: A computer-implemented method using a blockchain network includes: i) receiving, at a node in a blockchain network, a first transaction associated with a digital asset, the first transaction specifying at least: a) a first set of constraints on a second transaction to transfer control of the digital asset, the first set of constraints including one or more constraints that cause the second transaction to contain a set of data from the blockchain network; and b) a second set of constraints on the second transaction, the second set of constraints including a constraint that the set of data includes a block that includes the first transaction, the block included in a blockchain associated with the blockchain network; ii) verifying that the first set of constraints and the second set of constraints are satisfied; and iii) transferring control of the digital asset based at least in part on the verifying.

Abstract: The invention relates to distributed ledge technologies such as consensus-based blockchains. Computer-implemented methods for a secure random number generation within blockchain scripts are described. The invention is implemented using a blockchain network, which may be, for example, a Bitcoin blockchain. A first transaction that includes a puzzle is validated at a node in a blockchain network, with the first transaction being associated with a digital asset, and with a solution to the puzzle being indeterminable at a time of validation of the first transaction. A pseudorandom number, based at least in part on a solution to the puzzle that is included in a second transaction, is generated at least in part by validating the second transaction, the second transaction created to transfer control of the digital asset associated with the first transaction. Control of the digital asset is transferred based at least in part on the pseudorandom number.

Abstract: The present invention relates to a novel anti-cancer radiopharmaceutical treatment that is particularly suitable for targeting PARP enzyme expressing cancers. The novel treatment involves PARP-targeted Auger-emitting radiopharmaceutical compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: wherein: A1, A2 and A3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment cancer.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A computer-implemented method for controlling an external process or system and allowing a modification of blockchain transaction outputs, the method comprising one or more steps to generate a blockchain transaction comprising at least one signed input which comprises a value and at least one modifiable output, extract one or more values from one or more signed inputs associated with one or more combination locks, provide one of the values to a portion of logic to obtain a result, and use the result to modify at least one modifiable output of the transaction, wherein the transaction represents the result, wherein the values are extracted external from the blockchain transaction, and wherein the transaction are submitted to the blockchain.

Abstract: Computer-implemented methods for locking a blockchain transaction based on undetermined data are described. The invention is implemented using a blockchain network. This may, for example, be the Bitcoin blockchain. A locking node may include a locking script in a blockchain transaction to lock a digital asset. The locking script includes a public key for a determined data source and instructions to cause a validating node executing the locking script to verify the source of data provided in an unlocking script by: a) generating a modified public key based on the public key for the determined data source and based on data defined in the unlocking script; and b) evaluating a cryptographic signature in the unlocking script based on the modified public key. The blockchain transaction containing the locking script is sent by the locking node to the blockchain network. The lock may be removed using a cryptographic signature generated from a private key modified based on the data.

Abstract: Techniques are provided for causing an injection of a serialized previous transaction into a locking script. A first script, of a first transaction to be validated, causes a node to at least obtain a first set of field values corresponding to the first transaction and obtain a second set of field values corresponding to a particular transaction. A second script, included in a second transaction, causes the node to at least obtain the first set of field values and the second set of field values of the particular transaction supplied as a result of execution of the first script, extract a transaction identifier from the first set of field values, and determine, based at least in part on the second set of field values, that the particular transaction corresponds to the transaction identifier. The first transaction is validated by executing the first script and the second script.

Abstract: The invention relates to distributed ledge technologies such as consensus-based blockchains. Computer-implemented methods for a secure random number generation within blockchain scripts are described. The invention is implemented using a blockchain network, which may be, for example, a Bitcoin blockchain. A third transaction is validated. The third transaction is associated with a third digital asset and includes a first and second puzzle in a locking script. The first puzzle is included, in a first transaction, in a first locking script that encumbers transfer of control of a first digital. The second puzzle is included, in a second transaction, in a second locking script that encumbers transfer of control of a second digital asset. A pseudorandom number is generated based at least in part on solutions to the first and second puzzles. Control of the third digital asset is transferred based at least in part on the pseudorandom number.

Abstract: The invention relates to distributed ledge technologies such as consensus-based blockchains. Computer-implemented methods for a trustless, deterministic state machine are described. The invention is implemented using a blockchain network, which may be, for example, a Bitcoin blockchain. A first transaction validate is received at a node in a blockchain network. The first transaction includes a first script that, as a result of being executed, causes the node to at least obtain a first set of field values of the first transaction, a second set of field values of a second transaction, and an input. The second transaction is obtained.

Abstract: Techniques are provided for causing an injection of a serialized previous transaction into a locking script. A first script, of a first transaction to be validated, causes a node to at least obtain a first set of field values corresponding to the first transaction and obtain a second set of field values corresponding to a particular transaction. A second script, included in a second transaction, causes the node to at least obtain the first set of field values and the second set of field values of the particular transaction supplied as a result of execution of the first script, extract a transaction identifier from the first set of field values, and determine, based at least in part on the second set of field values, that the particular transaction corresponds to the transaction identifier. The first transaction is validated by executing the first script and the second script.

Abstract: A method of annotating known objects in road images captured from a sensor-equipped vehicle, the method implemented in an annotation system and comprising: receiving at the annotation system a road image containing a view of a known object; receiving ego localization data, as computed in a map frame of reference, via localization applied to sensor data captured by the sensor-equipped vehicle, the ego localization data indicating an image capture pose of the road image in the map frame of reference; determining, from a predetermined road map, an object location of the known object in the map frame of reference, the predetermined road map representing a road layout the map frame of reference, wherein the known object is one of: a piece of road structure, and an object on or adjacent a road; computing, in an image plane defined by the image capture pose, an object projection, by projecting an object model of the known object from the object location into the image plane; and storing, in an image database, image

Abstract: A technique for locking a blockchain transaction based on undetermined data, using a blockchain network. A locking node may include a locking script in a blockchain transaction to lock a digital asset. The locking script includes a public key for a determined data source and instructions to cause a validating node executing the locking script to verify the source of data provided in an unlocking script by: a) generating a modified public key based on the public key for the determined data source and based on data defined in the unlocking script; and b) evaluating a cryptographic signature in the unlocking script based on the modified public key. The blockchain transaction containing the locking script is sent by the locking node to the blockchain network. The lock may be removed using a cryptographic signature generated from a private key modified based on the data.

Abstract: The invention relates to distributed ledger technologies such as consensus-based blockchains, for example, a Bitcoin blockchain. Computer-implemented methods for a trustless, deterministic state machine that is embodied by the locking script of a spending transaction are described. The spending transaction transfers control of at least one digital asset or portion thereof. The spending transaction references a previous transaction that includes a locking script with a bytecode sequence. The spending transaction also includes a locking script with the same bytecode sequence. The spending transaction can be validated by verifying that the bytecode sequences of the locking scripts of the spending and previous transactions match one another. Control of the at least one digital asset or portion thereof can be transferred as a result of execution of the locking script. For example, the locking script can impose a set of conditions for validation of the spending transaction.

Abstract: The invention relates to distributed ledge technologies such as consensus-based blockchains. Computer-implemented methods for a secure random number generation within blockchain scripts are described. The invention is implemented using a blockchain network, which may be, for example, a Bitcoin blockchain. A third transaction is validated. The third transaction is associated with a third digital asset and includes a first and second puzzle in a locking script. The first puzzle is included, in a first transaction, in a first locking script that encumbers transfer of control of a first digital. The second puzzle is included, in a second transaction, in a second locking script that encumbers transfer of control of a second digital asset. A pseudorandom number is generated based at least in part on solutions to the first and second puzzles. Control of the third digital asset is transferred based at least in part on the pseudorandom number.

Abstract: Techniques are presented for causing, as a result of successfully verifying that a first set of constraints and a second set of constraints are satisfied, a second transaction to be recorded to a blockchain network. The method comprises receiving, at a node in a blockchain network, a first transaction that specifies at least: a first set of constraints on a second transaction, the first set of constraints including one or more constraints that cause the second transaction to contain a set of data from the blockchain network; and a second set of constraints on the second transaction, the second set of constraints including a constraint that the set of data includes a block that includes the first transaction, the block included in a blockchain associated with the blockchain network.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Trustless deterministic state machines can be implemented using a blockchain infrastructure and state machines can run concurrently over more than one blockchain transaction. Disclosed herein are processes, apparatuses, and articles of manufacture to create, at a node, a first transaction that includes 1) a first output having a first spendable value and a first locking script and 2) a second output having a second spendable value and a second locking script. Included, in the first locking script, is a first set of constraints on a first selected transaction output. Included, in the second locking script, a second set of constraints on a second selected transaction output. Furthermore, either the first set of constraints or the second set of constraints is configured to impose a constraint on a locking script of a spending transaction having as a spending transaction output the first selected transaction output or the second selected transaction output.

Abstract: There may be provided a computer-implemented method. It may be implemented using a blockchain network. The computer-implemented method includes: i) receiving, at a node in a blockchain network, a first transaction associated with a digital asset, the first transaction including a locking script that specifies a set of constraints on a second transaction to transfer control of the digital asset, one of the constraints being associated with a set of data; ii) obtaining the second transaction, the second transaction including an unlocking script that, as a result of being executed, causes the node to obtain the set of data; and iii) validating the second transaction by executing the locking script and the unlocking script.

Abstract: There may be provided a computer-implemented method. It may be implemented using a blockchain network such as, for example, the Bitcoin network. The computer-implemented method includes: i) receiving, at a node in a blockchain network, a first transaction associated with a digital asset, the first transaction including a first script that specifies a set of constraints on a second transaction to transfer control of the digital asset, the set of constraints including a constraint that a set of data obtained by the node includes information obtained from a blockchain associated with the blockchain network; ii) obtaining the second transaction, the second transaction including a second script that, as a result of being executed, causes the node to obtain the set of data; and iii) validating the second transaction by executing the first script and the second script.