Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A multilayer-stacked resistive random access memory device includes: first and second electrode layers; a resistive oxide layer which is electrically coupled to the first and second electrode layers, which exhibits resistive switching characteristics and which includes a metal oxide containing a first metal selected from the group consisting of W, Ti, Zr, Sn, Ta, Ni, Ag, Cu, Co, Hf, Ru, Mo, Cr, Fe, Al, and combinations thereof; and a sulfide layer contacting the resistive oxide layer and including a metal sulfide that contains a second metal that is the same as the first metal.

Abstract: An electron beam apparatus for patterned metal reduction, applied to generate metal lines or patterns on a substrate, includes an electron beam generating system with functions of collimating, focusing and scanning electron beams, an electron-transparent membrane of a vacuum chamber for allowing the electron beam to penetrate through, a stage mounted at a position to face the electron-transparent membrane, a substrate placed on the stage to face the electron-transparent membrane, a thin liquid layer containing metal ions and mounted on the substrate, and an environment control device for controlling the temperature, the pressure and the atmosphere around the substrate. A method for using the electron beam apparatus to generate the metal lines or patterns on the substrate is to focus the electron beam onto the substrate and have the electron beam to scan the substrate repeatedly along a predetermined path till a desired metal pattern is reduced on the substrate.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A colorimetric immunoassay of the present invention uses nanostructured material with high absorption and high scattering ability as a label material for biosensors. Subject matters to be measured may be characterized or quantified by determining the changes in optical properties of the nanostructured material. The biosensor of the present invention may be operated in broad light wavelength range and detected by direct observation with naked eye. The biosensor of the present invention may be also provided with advantages such as higher sensitivity and lower cost.

Abstract: The present invention relates to the field of electronic communications, which discloses a Universal Serial Bus device comprising an OTG controller used for connecting two external devices for data exchange; a first plug used for insertion of the first external device; a second plug used for insertion of the second external device; and the OTG controller that connects with the first plug and the second plug; wherein the Universal Serial Bus device also comprises a switching device that is used for controlling the connection of the first plug and the second plug, and performing data processing through the OTG controller. By changing the operating state of the switching device, data connection between mobile devices, connection between the computer and mobile device, using as a power supply line for charging mobile devices or batteries can be achieved, thereby increasing the versatility and portability of the Universal Serial Bus device.

Abstract: The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.

Abstract: The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.

Abstract: This invention relates to a process for producing a product stream with improved reduction of Conradson Carbon Residue (“CCR”) and a reduced average boiling point from a heavy hydrocarbon feedstream utilizing a high-pressure, low-energy separation process. The invention may be utilized to reduce the CCR content and reduce the average boiling point in heavy hydrocarbon feedstreams, such as whole crudes, topped crudes, synthetic crude blends, shale oils, bitumen, oil from tar sands, atmospheric resids, vacuum resids, or other heavy hydrocarbon streams. This invention also results in a process with an improved CCR separation efficiency while maintaining permeate flux rates.

Abstract: The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A batter mixer including a body, a lid coupled to the body, a paddle extending from the lid, a base coupled to the body, an outlet formed through the base, a handle coupled to the body, and a pad coupled to the handle and moveable from a position plugging the outlet to a position of not plugging the outlet.

Abstract: A wafer carrier comprises a supporting body having a height and comprising an opening, wherein a bottom surface of the opening is a curved surface; and a plurality of supporting rods formed around a periphery of the supporting body. Another aspect of the present application provides a manufacturing method of the wafer carrier. The method comprises forming an epitaxial layer on a growth substrate to form a wafer structure; measuring a curvature radius of the wafer structure; and providing the wafer carrier described above in accordance with the curvature radius of the wafer structure.

Abstract: A touch device includes a frame body, multiple first transmitters, multiple first receivers, multiple second transmitters, multiple second receivers and a connection unit. The frame body has a first side, a second side, a third side and a fourth side. Two ends of the first and third sides are respectively connected to the second and fourth sides. The first transmitters are disposed on the first side and the first receivers are disposed on the third side corresponding to the first transmitters to together define a horizontal detection area. The second transmitters are disposed on the second side and the second receivers are disposed on the fourth side corresponding to the second transmitters to together define a vertical detection area. A terminal of the connection unit is electrically connected to the first and second transmitters and receivers. The horizontal and vertical detection areas together form a three-dimensional detection area.

Abstract: A notebook touch input device includes a first main body, a second main body and at least one touch module. The first main body has a display module. The second main body is pivotally connected to the first main body. The first main body can be selectively closed onto the second main body or opened from the second main body. The second main body has a main surface corresponding to the display module. The touch module is disposed on the main surface and electrically connected to the second main body. The touch module includes multiple transmitters and multiple receivers arranged opposite to the transmitters. The transmitters and the receivers together define a touch space. By means of the notebook touch input device, the volume and thickness of the notebook are reduced and the notebook is more lightweight and the lifetime of the notebook is prolonged.

Abstract: The invention provides a GM-CSF neutralizing human monoclonal antibody, 1783J22, as well as methods of making and use thereof. The monoclonal antibody is further characterized by its ability to bind epitopes from GM-CSF proteins of multiple species.

Abstract: A touch panel detection device includes a substrate, at least one first and at least one second transmitter, at least one first and at least one second receiver and a connection unit. The substrate is a frame body having opposed first and second sides and opposed third and fourth sides. A first fixing section and a second fixing section are respectively disposed on the first and second sides. A third fixing section and a fourth fixing section are respectively disposed on the third and fourth sides. Opposed fixing sections are respectively parallelly arranged and misaligned from each other. The first and second transmitters are respectively disposed on the first and third fixing sections, while the first and second receivers are respectively disposed on the second and fourth fixing sections.

Abstract: An organic dye used in a dye-sensitized solar cell is described, having general formula (1): wherein Ar1 represents a substituted or unsubstituted arylene group, Ar2 and Ar3 each independently represent a substituted or unsubstituted aryl group, Sp1 represent a single bond or a spacer group allowing conjugation between Ar1 and the furan moiety, Sp2 represent a single bond or a spacer group allowing conjugation between the furan moiety and Ac, Ac represents an acceptor group, and Y represents an anchoring group.

Abstract: The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment.