Patents by Inventor Ying-Fei Wei
Ying-Fei Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20070154918Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 11, 2006Publication date: July 5, 2007Applicant: Human Genome Sciences, Inc.Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
-
Patent number: 7217529Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.Type: GrantFiled: March 16, 2005Date of Patent: May 15, 2007Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
-
Publication number: 20070048256Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.Type: ApplicationFiled: October 2, 2006Publication date: March 1, 2007Applicant: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Brent Kreider, Craig Rosen
-
Publication number: 20070020724Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 9, 2004Publication date: January 25, 2007Inventors: Steven Ruben, Jian Ni, Craig Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel Soppet, Laurie Brewer, Gregory Endress, Kenneth Carter, Michael Mucenski, Reinhard Ebner, David LaFleur, Henrik Olsen, Yanggu Shi, Paul Moore, George Komatsoulis
-
Publication number: 20060286593Abstract: The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.Type: ApplicationFiled: August 14, 2006Publication date: December 21, 2006Applicant: Human Genome Sciences, Inc.Inventors: Paul Meissner, Rebecca Fuldner, Ying Fei-Wei, Mark Adams
-
Publication number: 20060281095Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 3, 2004Publication date: December 14, 2006Applicant: Human Genome Sciences, Inc.Inventors: David LaFleur, Steven Ruben, Craig Rosen, Paul Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
-
Patent number: 7135551Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.Type: GrantFiled: October 4, 2002Date of Patent: November 14, 2006Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Brent L Kreider, Craig A Rosen
-
Publication number: 20060234342Abstract: Disclosed is a human is a hTopI-? polypeptide and DNA (RNA) encoding such hTopI-? polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-? for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.Type: ApplicationFiled: June 24, 2003Publication date: October 19, 2006Applicant: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Mark Adams, Robert Fleischmann
-
Publication number: 20060223077Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: September 20, 2005Publication date: October 5, 2006Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Reinhard Ebner, David LaFleur, Paul Moore, Henrik Olsen, Craig Rosen, Steven Ruben, Daniel Soppet, Paul Young, Yanggu Shi, Kimberly Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie Fischer, Ann Ferrie, Ping Fan, Ping Feng, Gregory Endress, Patrick Dillon, Kenneth Carter, Laurie Brewer, Guo-Liang Yu, Zhizhen Zeng, John Greene
-
Patent number: 7060261Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.Type: GrantFiled: April 3, 2002Date of Patent: June 13, 2006Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben
-
Patent number: 7049402Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.Type: GrantFiled: April 5, 2001Date of Patent: May 23, 2006Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Reiner Gentz, Jian Ni, Steven M Ruben
-
Publication number: 20060099622Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: October 11, 2005Publication date: May 11, 2006Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Paul Young, Joseph Kenny, Henrik Olsen, Paul Moore, Ying-Fei Wei, John Greene, Steven Ruben, Ding Liu, Paul Crocker
-
Publication number: 20060079670Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: September 20, 2005Publication date: April 13, 2006Applicant: Human Genome Sciences, Inc.Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
-
Publication number: 20060008882Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.Type: ApplicationFiled: September 13, 2005Publication date: January 12, 2006Applicant: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig Rosen, Steven Ruben
-
Patent number: 6979443Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.Type: GrantFiled: March 4, 2002Date of Patent: December 27, 2005Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Steven M. Ruben, Craig A. Rosen
-
Publication number: 20050255100Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.Type: ApplicationFiled: July 18, 2005Publication date: November 17, 2005Applicant: HUMAN GENOME SCIENCES, INC.Inventors: Ying-Fei Wei, Jian Ni, Reiner Gentz, Steven Ruben
-
Publication number: 20050208621Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: September 29, 2004Publication date: September 22, 2005Applicant: Human Genome Sciences, Inc.Inventors: Craig Rosen, Steven Ruben, Yi Li, ZhiZhen Zeng, Hla Kyaw, Carrie Fishcher, Haodong Li, Daniel Soppet, Reiner Gentz, Ying-Fei Wei, Paul Moore, Paul Young, John Greene, Ann Ferrie, Gregg Hastings
-
Publication number: 20050208591Abstract: The present invention relates to a novel CK?-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-6 protein. CK?-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK?-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.Type: ApplicationFiled: March 16, 2005Publication date: September 22, 2005Applicant: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Steven Ruben, Craig Rosen
-
Patent number: 6929921Abstract: The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.Type: GrantFiled: April 15, 2003Date of Patent: August 16, 2005Assignees: Human Genome Sciences, Inc., The University of North Carolina at Chapel HillInventors: Ying-Fei Wei, Steven M. Ruben, Aziz Sancar, Shiao-Wen D. Hsu, Aleksey G. Kazantsev
-
Patent number: 6919433Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: May 11, 2001Date of Patent: July 19, 2005Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie L. Fischer, Haodong Li, Daniel R. Soppet, Reiner L. Gentz, Ying-Fei Wei, Paul A. Moore, Paul E. Young, John M. Greene, Ann M. Ferrie, Gregg A. Hastings