Patents by Inventor Ying-Fei Wei
Ying-Fei Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6114503Abstract: The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.Type: GrantFiled: November 4, 1997Date of Patent: September 5, 2000Assignees: Human Genome Sciences, Inc., University of North Carolina at Chapel HillInventors: Ying-Fei Wei, Steven M. Ruben, Aziz Sancar, Shiao-Wen D. Hsu, Aleksey G. Kazantsev
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Patent number: 6103871Abstract: A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.Type: GrantFiled: August 21, 1997Date of Patent: August 15, 2000Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Ewen F. Kirkness
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Patent number: 6074839Abstract: The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.Type: GrantFiled: June 6, 1995Date of Patent: June 13, 2000Assignee: Human Genome Sciences, Inc.Inventors: Paul S. Meissner, Rebecca A. Fuldner, Ying Fei-Wei, Mark D. Adams
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Patent number: 6063376Abstract: A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.Type: GrantFiled: October 16, 1997Date of Patent: May 16, 2000Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Ewen F. Kirkness
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Patent number: 6051222Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutation in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: March 29, 1999Date of Patent: April 18, 2000Assignee: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Patent number: 6013473Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: March 7, 1997Date of Patent: January 11, 2000Assignee: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Patent number: 5981231Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular isolated nucleic acid molecules are provided encoding the chemokine .beta.-15 protein. Chemokine .beta.-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.Type: GrantFiled: June 16, 1997Date of Patent: November 9, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Brent L. Kreider, Craig A. Rosen
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Patent number: 5968803Abstract: Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.Type: GrantFiled: March 2, 1998Date of Patent: October 19, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Mark D. Adams, Robert D. Fleischmann
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Patent number: 5945303Abstract: The invention relates to hHSP polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: April 11, 1997Date of Patent: August 31, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Haodong Li
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Patent number: 5929225Abstract: A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.Type: GrantFiled: February 13, 1998Date of Patent: July 27, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Granger G. Sutton, III
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Patent number: 5914258Abstract: A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.Type: GrantFiled: June 2, 1995Date of Patent: June 22, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Ewen F. Kirkness
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Patent number: 5858705Abstract: A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.Type: GrantFiled: June 5, 1995Date of Patent: January 12, 1999Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Guo-Liang Yu, William A. Haseltine
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Patent number: 5747312Abstract: A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.Type: GrantFiled: January 15, 1997Date of Patent: May 5, 1998Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Granger G. Sutton, III
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Patent number: 5723311Abstract: Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.Type: GrantFiled: June 2, 1995Date of Patent: March 3, 1998Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Mark D. Adams, Robert D. Fleischmann
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Patent number: 5695980Abstract: A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.Type: GrantFiled: June 6, 1995Date of Patent: December 9, 1997Assignee: Human Genome SciencesInventors: Ying-Fei Wei, Ewen F. Kirkness
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Patent number: 5618717Abstract: A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.Type: GrantFiled: June 5, 1995Date of Patent: April 8, 1997Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Granger G. Sutton, III