Abstract: An applicator head for applying a product including a cosmetic, care, or pharmaceutical product onto the keratinous substrate. The applicator head includes an applying member elongated along a longitudinal axis. The applying member includes at least one sidewall and a distal end face that is inclined. The at least one sidewall has an extended portion that extends beyond the distal end face of the applying member. The extended portion peripherally encloses the distal end face to define a cavity at the distal end portion of the applying member. The cavity opens upwardly at a distal end of the applying member and has a closed bottom end that is defined by the distal end face of the applying member. The cavity is suitable for holding a cosmetic product. The extended portion is in form of multiple petals that surround the distal end face.

Abstract: Provided herein are multispecific antibodies containing a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: A water supply device (10) and a tube connector structure (2) thereof, which are used for an electronic device (100) having a water inlet (101) and a water outlet (102), are disclosed. The tube connector structure (2) includes a connecting plate (21) and two tube connector plugs (22) passing through and fixed to the connecting plate (21). One of the tube connector plugs (22) is connected with the water inlet (101), and the other one of the tube connector plugs (22) is connected with the water outlet (102). Therefore, advantages of rapid connection and disconnection between the water supply device (10) and the tube connector structure (2) and saving time and labor in assembling may be accomplished.

Abstract: Systems and methods for implementing robotic process automation (RPA) in the cloud are provided. An instruction for managing an RPA robot is received at an orchestrator in a cloud computing environment from a user in a local computing environment. In response to receiving the instruction, the instruction for managing the RPA robot is effectuated.

Abstract: Provided herein is a multispecific antibody containing two antigen binding arms capable of binding to a first target and at least one antigen binding arm capable of binding to a second target. The multispecific antibody includes a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: Provided herein are trispecific antibodies containing three antigen binding arms each capable of binding to a different target, wherein each antigen binding arm contains a different lambda or kappa charge pair introduced into the interface of the respective heavy and light chains to reduce chain mispairing.

Abstract: Methods for producing synthetic single-domain monoclonal antibody libraries using humanized llama nanobody framework sequences, libraries obtainable by the method, as well as antibodies selected from the libraries are described. In particular, synthetic single-domain monoclonal antibodies that specifically bind to the spike protein of SARS-COV-2 and neutralize SARS-COV-2 infection are described. Use of the disclosed antibodies for the detection, prophylaxis and treatment of SARS-COV-2 infection is described.

Abstract: A dropper package for dispensing and applying a fluid product, comprising a container body for storing the fluid product and a dropper assembly coupled to one end of the container body. The dropper assembly comprises a deformable bulb, a tube with its proximal end connected to the deformable bulb, and an applicator tip connected to a distal end of the tube. The applicator tip comprises a shank portion and an applying member that has two opposing main application faces. The applicator tip includes a groove on its outer surface that extends from a proximal end of the shank portion to at least a length of the applying member on one of the two opposing main application faces. The applying member is adapted to apply and dispense the fluid product in a very controlled manner as well as massage the user's keratinous surface.

Abstract: A semiconductor structure is provided. The semiconductor structure includes a pad layer, a first conductive layer, a second conductive layer, an interlayer dielectric layer, and a control gate. The pad layer is disposed on a substrate. The first conductive layer is disposed on the pad layer. The second conductive layer is disposed on the first conductive layer. The interlayer dielectric layer is disposed on the first conductive layer and the second conductive layer and is in contact with top surfaces of the first conductive layer and the second conductive layer. The control gate is disposed on the interlayer dielectric layer.

Abstract: A cosmetic package comprising a roller for discharging a powder product. The cosmetic package comprises an outer cap, an inner cap, an insert, the roller, a container, and a base plug. The container has an open bottom end which is closed by the base plug. The insert is mounted within the container above a cosmetics accommodating space of the container. The roller is disposed rotatably within the cosmetics accommodating space of the container and another portion of the roller extending outside the cosmetics accommodating space from an aperture located in the insert. The inner cap forms a tight seal with the insert and the roller to prevent leakage of powder product from the container.

Abstract: A method and a system for predicting battery health based on distance driven on a full battery load with machine learning model are provided. The method includes: obtaining historical vehicle telematics of vehicles, wherein the historical vehicle telematics comprise at least one of the following: odometer readings, battery SOC, vehicle speed, battery-module temperatures, and battery-cell voltages; creating a distance driven model according to a relationship between a distance driven on a full battery load of vehicles and the historical vehicle telematics; obtaining a distance driven on a full battery load of a vehicle based on the distance driven model by using real-time vehicle telematics of the vehicle as model input; predicting battery health of the vehicle by comparing the obtained distance with a reference distance value.

Abstract: An isolation structure, comprising: an isolation material layer, filled in a trench of a substrate; and a protection layer, having two portions extending from a topmost surface of the substrate to a top surface of the isolation material layer across boundaries of the trench, and covering opposite edges of the isolation material layer, wherein the two portions of the protection layer are laterally spaced apart from each other, and the protection layer has an etching selectivity with respect to the isolation material layer.

Abstract: A method of forming a semiconductor structure includes forming a mask layer on a substrate. The mask layer and the substrate include an opening. An isolation structure is formed in the opening. The mask layer is removed. A first conductive layer is formed on the isolation structure and the substrate. A first implantation process is performed on the first conductive layer and the isolation structure, to form a doped portion in the first conductive layer and a doped portion in the isolation structure. A second conductive layer is formed on the first conductive layer and the isolation structure. A first planarization process is performed, so that the top surfaces of the second conductive layer, the first conductive layer, and the isolation structure are aligned.

Abstract: An applicator head for applying a product including a cosmetic, care, or pharmaceutical product onto the keratinous substrate. The applicator head includes an applying member elongated along a central longitudinal axis. The applying member includes a front face, a rear face opposing the front face, a left face, and a right face opposing the left face. The applying member has an axial zigzag groove extending along a length of the applying member on at least one of the front face and the rear face of the applying member. The axial zigzag groove has vertices on both side of the central longitudinal axis of the applying member. Further, the applying member includes side grooves disposed on each side of the axial zigzag groove. The axial zigzag groove and the side grooves outline beads on an outer surface of the applying member.

Abstract: A method for forming an isolation structure includes: forming a trench at a surface of a substrate; forming a mask pattern on the substrate, wherein the mask pattern has an opening communicated with the trench; filling a first isolation material layer in the opening and the trench, wherein a surface of the first isolation material layer defines a first recess; filling a second isolation material layer into the first recess; partially removing the first and second isolation material layers, to form a second recess, performing first and second oblique ion implantation processes, to form damage regions in the first isolation material layer; performing a decoupled plasma treatment, to transform portions of the damage regions into a protection layer having etching selectivity with respect to the damage regions; and removing the damage regions.

Abstract: A brush for applying a product including a cosmetic, care, or pharmaceutical product onto the keratinous surface of a user. The applying member includes a support head and a plurality of bristles extends from a distal end face of the support head along a longitudinal axis of the support head. The distal end face of the support head comprises a first distal end face and a second distal end face. The first distal end face and the second distal end face are substantially flat surfaces that intersect each other to form a ridge on the distal end face. The ridge on the distal end face extends along an axis perpendicular to a longitudinal axis of the support head.

Abstract: A cosmetic applicator for applying a product including a cosmetic, care or pharmaceutical product onto the keratinous substrate. The cosmetic applicator comprises an applying member and a shank. The applying member comprises a first application face and a second application face opposite to the first application face, a first peripheral edge, and a second peripheral edge opposite the first peripheral edge. The applying member has a plurality of bulged portions on the second application face and a corresponding plurality of depressed portions on the first application face. The plurality of bulged portions extend from the first peripheral edge towards a central longitudinal axis of the applying member but do not extend up to the second peripheral edge. Each of the plurality of bulged portions has an arched structure, and each of the plurality of depressed portion has a concave bowl structure.

Abstract: A refillable container for a stick type cosmetic product comprising a cap, a refill cartridge and a base assembly. The base assembly comprises an outer shell and a button member. The refill cartridge is configured to be detachably received at least partially within a cavity of the outer shell of the base assembly such that the refill cartridge may be removed and replaced from said base assembly by pressing the button member provided in the base assembly.